SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3on7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		5 / 11 ILE A 131
ALA A 220
LEU A 178
ILE A 213
PHE A 225
 None
 0.96A 1dyrA-3on7A:
undetectable		 1dyrA-3on7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		5 / 12 LEU A 119
LEU A 120
ILE A 209
ILE A 213
LEU A  21
 None
 1.01A 1tw4B-3on7A:
undetectable		 1tw4B-3on7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		6 / 12 LEU A 150
HIS A 173
ASP A 175
HIS A 230
SER A 246
PHE A 250
 None
 0.58A 1uobA-3on7A:
23.2		 1uobA-3on7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		6 / 12 LEU A 150
HIS A 173
ASP A 175
LEU A 190
HIS A 230
PHE A 250
 None
 0.42A 1uobA-3on7A:
23.2		 1uobA-3on7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		6 / 11 HIS A 173
ASP A 175
THR A 180
HIS A 230
VAL A 232
SER A 246
 None
 0.61A 1uofA-3on7A:
22.3		 1uofA-3on7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		5 / 11 HIS A 230
ASP A 175
THR A 180
VAL A 232
SER A 246
 None
 1.43A 1uofA-3on7A:
22.3		 1uofA-3on7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		4 / 7 PHE A  68
PRO A 157
ALA A  71
PHE A  49
 None
 0.97A 2vcvL-3on7A:
undetectable		 2vcvL-3on7A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		5 / 10 TYR A 156
LEU A 154
HIS A 173
ASP A 175
HIS A 230
 None
 1.32A 3kcxA-3on7A:
9.7		 3kcxA-3on7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		3 / 3 HIS A  90
PHE A  49
PHE A  50
 None
 0.79A 3lk0D-3on7A:
undetectable		 3lk0D-3on7A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		4 / 4 LEU A 150
ILE A 245
TYR A 108
TYR A  88
 None
 1.14A 3vt7A-3on7A:
undetectable		 3vt7A-3on7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		3 / 3 TYR A  88
HIS A  90
ARG A 152
 None
 1.20A 4e7bC-3on7A:
1.2		 4e7bC-3on7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		4 / 4 ASN A  61
LEU A 150
PHE A  68
TYR A  88
 None
 1.17A 4u14A-3on7A:
0.0		 4u14A-3on7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		5 / 11 ASN A 113
VAL A  91
THR A 149
TYR A  89
PRO A  98
 None
 1.44A 5jh7B-3on7A:
undetectable		 5jh7B-3on7A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY
(Shewanella
oneidensis) 		5 / 10 VAL A 181
GLY A  27
ILE A 123
LEU A 120
ALA A 116
 None
 1.08A 5vm8B-3on7A:
undetectable		 5vm8B-3on7A:
22.73