SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3onp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 6 LEU A 129
ASP A 126
LEU A 122
GLY A 116
ARG A  11
 None
None
None
ACY  A 250 (-4.5A)
None
 1.35A 1mt1G-3onpA:
undetectable
1mt1J-3onpA:
undetectable		 1mt1G-3onpA:
12.18
1mt1J-3onpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 7 ARG A  11
LEU A 129
ASP A 126
LEU A 122
GLY A 116
 None
None
None
None
ACY  A 250 (-4.5A)
 1.36A 1mt1H-3onpA:
undetectable
1mt1K-3onpA:
undetectable		 1mt1H-3onpA:
19.68
1mt1K-3onpA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 7 ARG A  11
LEU A 129
ASP A 126
LEU A 122
GLY A 116
 None
None
None
None
ACY  A 250 (-4.5A)
 1.40A 1n13D-3onpA:
undetectable
1n13E-3onpA:
undetectable		 1n13D-3onpA:
19.68
1n13E-3onpA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 8 LEU A 129
ASP A 126
LEU A 122
GLY A 116
ARG A  11
 None
None
None
ACY  A 250 (-4.5A)
None
 1.40A 1n13A-3onpA:
undetectable
1n13F-3onpA:
undetectable		 1n13A-3onpA:
12.18
1n13F-3onpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 6 ARG A  11
LEU A 129
ASP A 126
LEU A 122
GLY A 116
 None
None
None
None
ACY  A 250 (-4.5A)
 1.41A 1n13H-3onpA:
undetectable
1n13K-3onpA:
undetectable		 1n13H-3onpA:
19.68
1n13K-3onpA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 7 LEU A 129
ASP A 126
LEU A 122
GLY A 116
ARG A  11
 None
None
None
ACY  A 250 (-4.5A)
None
 1.40A 1n13G-3onpA:
undetectable
1n13J-3onpA:
undetectable		 1n13G-3onpA:
12.18
1n13J-3onpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 8 ARG A  11
LEU A 129
ASP A 126
LEU A 122
GLY A 116
 None
None
None
None
ACY  A 250 (-4.5A)
 1.39A 2qqcH-3onpA:
undetectable
2qqcK-3onpA:
undetectable		 2qqcH-3onpA:
19.84
2qqcK-3onpA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 11 THR A  80
ALA A  82
GLY A 116
GLY A 121
LEU A 145
 BME  A 251 ( 4.4A)
BME  A 251 (-3.8A)
ACY  A 250 (-4.5A)
ACY  A 250 (-3.5A)
BME  A 251 ( 3.9A)
 0.73A 3dcmX-3onpA:
14.2		 3dcmX-3onpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 12 ASN A  17
PHE A 115
GLY A 116
GLY A 121
LEU A 145
 CL  A 253 (-4.4A)
None
ACY  A 250 (-4.5A)
ACY  A 250 (-3.5A)
BME  A 251 ( 3.9A)
 0.91A 3nk7B-3onpA:
16.5		 3nk7B-3onpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 9 VAL A  36
ILE A  35
ARG A  34
LEU A  33
GLY A  19
 None
None
BME  A 254 (-3.3A)
None
None
 0.92A 4kukA-3onpA:
undetectable		 4kukA-3onpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 12 THR A  80
GLY A 116
GLY A 121
LEU A 145
LEU A 147
 BME  A 251 ( 4.4A)
ACY  A 250 (-4.5A)
ACY  A 250 (-3.5A)
BME  A 251 ( 3.9A)
ACY  A 250 ( 4.5A)
 0.70A 5l0zA-3onpA:
17.0		 5l0zA-3onpA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		5 / 10 THR A  80
GLY A 116
GLY A 121
LEU A 145
LEU A 147
 BME  A 251 ( 4.4A)
ACY  A 250 (-4.5A)
ACY  A 250 (-3.5A)
BME  A 251 ( 3.9A)
ACY  A 250 ( 4.5A)
 0.77A 5l0zB-3onpA:
7.0		 5l0zB-3onpA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 108
ILE A   3
TRP A 158
GLN A 161
 None
 1.09A 5vlmD-3onpA:
undetectable		 5vlmD-3onpA:
25.00