SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3onq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		5 / 9 LEU A 123
ILE A  56
GLY A  57
GLY A  58
CYH A 108
 None
None
None
None
GOL  A 269 (-2.6A)
 0.98A 2qmmA-3onqA:
undetectable		 2qmmA-3onqA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		5 / 11 LEU A 123
ILE A  56
GLY A  57
GLY A  58
CYH A 108
 None
None
None
None
GOL  A 269 (-2.6A)
 0.92A 2qmmA-3onqA:
undetectable
2qmmB-3onqA:
undetectable		 2qmmA-3onqA:
23.31
2qmmB-3onqA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 4 GLY A 188
GLU A 189
ASP A 258
TYR A 179
 None
 1.45A 2yvlC-3onqA:
undetectable		 2yvlC-3onqA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		3 / 3 LEU A 163
TRP A 236
GLY A 235
 None
 0.77A 3l35A-3onqA:
undetectable
3l35H-3onqA:
undetectable		 3l35A-3onqA:
14.81
3l35H-3onqA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		3 / 3 LEU A 163
TRP A 236
GLY A 235
 None
 0.75A 3l35B-3onqA:
undetectable
3l35K-3onqA:
undetectable		 3l35B-3onqA:
14.81
3l35K-3onqA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 7 THR A 107
LEU A 137
GLN A 145
LEU A 144
 None
None
GOL  A 264 (-2.8A)
None
 1.01A 4ib4A-3onqA:
undetectable		 4ib4A-3onqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 6 THR A 107
LEU A 137
GLN A 145
LEU A 144
 None
None
GOL  A 264 (-2.8A)
None
 1.05A 4nc3A-3onqA:
undetectable		 4nc3A-3onqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 7 ILE A  71
GLY A  57
THR A 140
LEU A 137
 None
 0.90A 4zdzA-3onqA:
undetectable		 4zdzA-3onqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 7 ILE A  71
GLY A  57
THR A 140
LEU A 137
 None
 0.80A 4ze3A-3onqA:
undetectable		 4ze3A-3onqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 4 LEU A  93
ILE A  85
GLY A  57
ILE A  71
 None
 0.89A 5dzk3-3onqA:
undetectable
5dzkm-3onqA:
undetectable		 5dzk3-3onqA:
1.20
5dzkm-3onqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 5 LEU A  93
PHE A 115
ILE A  85
ILE A  71
 None
 1.04A 5dzk4-3onqA:
undetectable
5dzkg-3onqA:
undetectable
5dzkm-3onqA:
undetectable
5dzkn-3onqA:
undetectable		 5dzk4-3onqA:
1.20
5dzkg-3onqA:
23.28
5dzkm-3onqA:
22.94
5dzkn-3onqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		5 / 5 PHE A 115
ILE A  85
GLY A  57
ILE A  71
LEU A  93
 None
 1.07A 5dzkB-3onqA:
undetectable
5dzkI-3onqA:
undetectable
5dzkW-3onqA:
undetectable		 5dzkB-3onqA:
23.28
5dzkI-3onqA:
22.94
5dzkW-3onqA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 5 ILE A  85
GLY A  57
ILE A  71
LEU A  93
 None
 0.84A 5dzki-3onqA:
undetectable
5dzkj-3onqA:
undetectable
5dzkx-3onqA:
undetectable		 5dzki-3onqA:
22.94
5dzkj-3onqA:
22.94
5dzkx-3onqA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 4 ILE A  85
GLY A  57
ILE A  71
LEU A  93
 None
 0.89A 5dzkl-3onqA:
undetectable
5dzkz-3onqA:
undetectable		 5dzkl-3onqA:
22.94
5dzkz-3onqA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 8 ILE A  71
GLY A  57
THR A 140
LEU A 137
 None
 0.88A 5esfA-3onqA:
undetectable		 5esfA-3onqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 8 ILE A  71
GLY A  57
THR A 140
LEU A 137
 None
 0.81A 5esjA-3onqA:
undetectable		 5esjA-3onqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		4 / 8 THR A 248
TYR A 245
TRP A 236
LEU A 178
 None
 1.47A 5kxiD-3onqA:
undetectable
5kxiE-3onqA:
undetectable		 5kxiD-3onqA:
20.45
5kxiE-3onqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		3 / 3 LEU A 121
SER A 116
PHE A 115
 None
 0.54A 6fgcA-3onqA:
undetectable		 6fgcA-3onqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION
(Bifidobacterium
adolescentis) 		3 / 3 ASP A 192
LEU A 197
ARG A 255
 None
None
SO4  A 265 (-3.9A)
 0.84A 7dfrA-3onqA:
undetectable		 7dfrA-3onqA:
20.15