SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		3 / 3 TRP A 136
ALA A 134
VAL A 131
 None
 0.82A 1c4dA-3oo3A:
undetectable
1c4dB-3oo3A:
undetectable		 1c4dA-3oo3A:
3.83
1c4dB-3oo3A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3001_1
(SERUM ALBUMIN)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 9 LEU A 342
ARG A 343
LEU A 267
HIS A 322
ALA A 335
 None
 1.50A 1hk2A-3oo3A:
1.1		 1hk2A-3oo3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 8 ASP A 314
ILE A 315
THR A 316
LEU A 251
 None
 0.69A 1hmyA-3oo3A:
undetectable		 1hmyA-3oo3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 7 GLN A 341
LEU A 337
LEU A 147
GLY A 148
 None
HEM  A 400 ( 4.7A)
None
None
 0.80A 2qqcD-3oo3A:
undetectable
2qqcE-3oo3A:
undetectable		 2qqcD-3oo3A:
15.14
2qqcE-3oo3A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 8 GLN A 341
LEU A 337
LEU A 147
GLY A 148
 None
HEM  A 400 ( 4.7A)
None
None
 0.90A 2qqcH-3oo3A:
undetectable
2qqcK-3oo3A:
undetectable		 2qqcH-3oo3A:
15.14
2qqcK-3oo3A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		3 / 3 PRO A   4
LEU A   5
GLN A   8
 None
 0.69A 3hznG-3oo3A:
undetectable
3hznH-3oo3A:
undetectable		 3hznG-3oo3A:
17.47
3hznH-3oo3A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 4 ILE A 200
ARG A  89
ILE A 203
THR A 184
 None
 1.20A 3ia4C-3oo3A:
undetectable		 3ia4C-3oo3A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 6 ARG A 109
ARG A 102
GLY A 198
GLU A 206
 None
 1.15A 3k9fA-3oo3A:
undetectable
3k9fB-3oo3A:
undetectable
3k9fD-3oo3A:
undetectable		 3k9fA-3oo3A:
23.43
3k9fB-3oo3A:
23.43
3k9fD-3oo3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 8 LYS A  40
ASP A 296
LEU A  27
LEU A 298
 None
 0.94A 3lm8A-3oo3A:
undetectable
3lm8C-3oo3A:
undetectable		 3lm8A-3oo3A:
19.54
3lm8C-3oo3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 6 PHE A 130
ALA A 134
ALA A 345
LEU A 118
 None
 0.94A 4dtzA-3oo3A:
31.9		 4dtzA-3oo3A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 6 PHE A 130
ALA A 134
ALA A 345
LEU A 118
 None
 0.93A 4dtzB-3oo3A:
32.0		 4dtzB-3oo3A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		3 / 3 PHE A 121
ASP A 119
ARG A 352
 None
 0.75A 4eahF-3oo3A:
undetectable		 4eahF-3oo3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		3 / 3 PHE A 121
ASP A 119
ARG A 352
 None
 0.75A 4eahG-3oo3A:
undetectable		 4eahG-3oo3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 9 GLY A 177
LEU A 219
ILE A 161
LEU A 157
ILE A 200
 None
 0.78A 5vkqC-3oo3A:
1.7
5vkqD-3oo3A:
1.7		 5vkqC-3oo3A:
12.38
5vkqD-3oo3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 MET A 231
GLN A 234
ALA A 236
LEU A 342
VAL A 349
 HEM  A 400 ( 3.9A)
HEM  A 400 ( 4.7A)
None
None
None
 1.08A 5vlmG-3oo3A:
undetectable		 5vlmG-3oo3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3oo3 OXY PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 6 ILE A 161
LEU A 157
ARG A 173
THR A 174
 None
 1.10A 6nmfN-3oo3A:
undetectable
6nmfW-3oo3A:
undetectable		 6nmfN-3oo3A:
21.86
6nmfW-3oo3A:
9.26