SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		3 / 3 TRP A 206
HIS A 196
MET A 200
 None
 0.85A 1l5qB-3oo9A:
undetectable		 1l5qB-3oo9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 PHE A 183
VAL A 391
PHE A 215
ALA A 399
ALA A 395
 None
 1.21A 1q23A-3oo9A:
undetectable
1q23B-3oo9A:
undetectable		 1q23A-3oo9A:
20.29
1q23B-3oo9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		4 / 5 PHE A 359
LEU A 188
MET A 200
LEU A 375
 GOL  A 414 (-3.5A)
None
None
None
 1.45A 1skxA-3oo9A:
undetectable		 1skxA-3oo9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		4 / 5 ALA A 229
PHE A 171
ASN A 230
ASP A 381
 None
 1.09A 1yc2D-3oo9A:
undetectable		 1yc2D-3oo9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 VAL A  98
ILE A  95
PHE A  21
PHE A  34
ALA A 316
 None
 1.42A 3apwB-3oo9A:
undetectable		 3apwB-3oo9A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		4 / 6 MET A  38
VAL A  49
ILE A 311
ILE A  19
 None
 0.77A 3gcsA-3oo9A:
undetectable		 3gcsA-3oo9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		4 / 6 MET A  38
VAL A  49
ILE A 311
ILE A  19
 None
 0.70A 3hegA-3oo9A:
undetectable		 3hegA-3oo9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		4 / 8 PHE A 320
TYR A 127
ALA A  33
THR A  53
 None
None
None
SO4  A 407 ( 4.3A)
 1.03A 3l4dD-3oo9A:
undetectable		 3l4dD-3oo9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 PHE A 106
ALA A 331
ILE A 311
GLY A 291
LEU A 113
 None
 1.12A 4dm8B-3oo9A:
undetectable		 4dm8B-3oo9A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		4 / 4 PRO A 295
LEU A  67
ILE A  63
ARG A  82
 None
 1.45A 4f4dA-3oo9A:
undetectable		 4f4dA-3oo9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 ALA A  41
PHE A  21
SER A  73
LEU A 294
THR A  42
 None
 1.47A 4kyaB-3oo9A:
undetectable		 4kyaB-3oo9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 ALA A  41
PHE A  21
SER A  73
LEU A 294
THR A  42
 None
 1.47A 4kyaD-3oo9A:
undetectable		 4kyaD-3oo9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 ALA A  41
PHE A  21
SER A  73
LEU A 294
THR A  42
 None
 1.45A 4kyaF-3oo9A:
undetectable		 4kyaF-3oo9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 ALA A  41
PHE A  21
SER A  73
LEU A 294
THR A  42
 None
 1.48A 4kyaH-3oo9A:
undetectable		 4kyaH-3oo9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 12 ALA A 179
ASP A 361
PHE A 250
PRO A 288
ILE A 185
 None
GOL  A 414 ( 4.4A)
None
None
None
 0.91A 4m2xA-3oo9A:
undetectable		 4m2xA-3oo9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		5 / 9 ALA A  41
PHE A  21
THR A  20
ASN A  24
THR A  76
 None
 1.34A 4z7fE-3oo9A:
0.0		 4z7fE-3oo9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		6 / 12 ALA A 258
PHE A 270
ILE A 342
GLN A 343
SER A 346
PHE A 134
 SO4  A 409 ( 4.2A)
None
None
None
None
None
 1.49A 5hgcA-3oo9A:
undetectable		 5hgcA-3oo9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		3 / 3 ASP A 286
ASN A 254
GLN A 255
 None
None
GOL  A 414 (-3.8A)
 0.80A 5k7uA-3oo9A:
undetectable		 5k7uA-3oo9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH
(Actinoplanes
sp.
SE50/110) 		4 / 6 TYR A 310
VAL A  49
VAL A  47
THR A  45
 None
 1.35A 6f32B-3oo9A:
undetectable		 6f32B-3oo9A:
23.05