SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ooi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		4 / 7 LEU A 230
TYR A 207
THR A  98
ASN A 144
 SAM  A 237 (-4.8A)
None
SO4  A 235 (-3.8A)
SAM  A 237 (-3.9A)
 1.36A 1afsA-3ooiA:
undetectable		 1afsA-3ooiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		4 / 7 LEU A 230
TYR A 207
THR A  98
ASN A 144
 SAM  A 237 (-4.8A)
None
SO4  A 235 (-3.8A)
SAM  A 237 (-3.9A)
 1.36A 1afsB-3ooiA:
undetectable		 1afsB-3ooiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		4 / 5 LEU A 191
VAL A 189
TYR A 120
THR A 178
 None
 1.34A 1nw3A-3ooiA:
undetectable		 1nw3A-3ooiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 LEU A 124
ILE A 156
ARG A  26
GLY A 162
LYS A 161
 None
None
SO4  A 236 (-3.5A)
None
None
 1.12A 2bxmA-3ooiA:
undetectable		 2bxmA-3ooiA:
17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		9 / 12 ARG A 101
GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 219
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.72A 2r3aA-3ooiA:
19.6		 2r3aA-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 ARG A 101
TYR A 120
HIS A 170
TYR A 207
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 1.46A 2r3aA-3ooiA:
19.6		 2r3aA-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 TYR A 146
HIS A 170
TYR A 207
CYH A 219
LYS A 220
CYH A 221
LEU A 230
 SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.96A 2r3aA-3ooiA:
19.6		 2r3aA-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		12 / 12 ARG A 101
GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.00A 3ooiA-3ooiA:
40.1		 3ooiA-3ooiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
CYH A 171
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
None
SAM  A 237 (-4.8A)
 1.30A 3ooiA-3ooiA:
40.1		 3ooiA-3ooiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.42A 3opeA-3ooiA:
26.0		 3opeA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 9 GLY A 102
TRP A 103
TYR A 146
ASN A 169
TYR A 207
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
None
 0.38A 3opeB-3ooiA:
24.4		 3opeB-3ooiA:
41.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.97A 3qxyA-3ooiA:
6.0		 3qxyA-3ooiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.95A 3rc0B-3ooiA:
5.7		 3rc0B-3ooiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.34A 3rq4A-3ooiA:
9.6		 3rq4A-3ooiA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.36A 3s8pA-3ooiA:
8.6		 3s8pA-3ooiA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 PHE A 145
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 None
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 1.49A 3s8pA-3ooiA:
8.6		 3s8pA-3ooiA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.37A 4bupA-3ooiA:
8.9		 4bupA-3ooiA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 PHE A 145
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 None
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 1.46A 4bupB-3ooiA:
9.8		 4bupB-3ooiA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		3 / 3 ARG A  88
GLU A  68
TYR A  90
 None
 0.96A 4r29D-3ooiA:
undetectable		 4r29D-3ooiA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.28A 4ynmA-3ooiA:
27.0		 4ynmA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.21A 4ynmA-3ooiA:
27.0		 4ynmA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.26A 4ynmB-3ooiA:
25.1		 4ynmB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.34A 4ynmB-3ooiA:
25.1		 4ynmB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 219
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 1.42A 4ynmB-3ooiA:
25.1		 4ynmB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 219
LYS A 220
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
ZN  A 232 (-2.3A)
 0.46A 4ynpA-3ooiA:
26.4		 4ynpA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 0.97A 4ynpA-3ooiA:
26.4		 4ynpA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.44A 4ynpA-3ooiA:
26.4		 4ynpA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 10 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.14A 4ynpB-3ooiA:
24.4		 4ynpB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 10 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.36A 4ynpB-3ooiA:
24.4		 4ynpB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 10 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 219
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 1.42A 4ynpB-3ooiA:
24.4		 4ynpB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.14A 4ypaA-3ooiA:
27.0		 4ypaA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.28A 4ypaA-3ooiA:
27.0		 4ypaA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.54A 4ypaA-3ooiA:
27.0		 4ypaA-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.64A 4ypaB-3ooiA:
26.0		 4ypaB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.38A 4ypaB-3ooiA:
26.0		 4ypaB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.24A 4ypaB-3ooiA:
26.0		 4ypaB-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.56A 4ypaC-3ooiA:
26.7		 4ypaC-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.14A 4ypaD-3ooiA:
25.8		 4ypaD-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.50A 4ypaD-3ooiA:
25.8		 4ypaD-3ooiA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.38A 4ypeA-3ooiA:
26.3		 4ypeA-3ooiA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.36A 4ypeB-3ooiA:
25.2		 4ypeB-3ooiA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.37A 4ypeB-3ooiA:
25.2		 4ypeB-3ooiA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.20A 4ypuA-3ooiA:
26.4		 4ypuA-3ooiA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.29A 4ypuA-3ooiA:
26.4		 4ypuA-3ooiA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
 0.66A 4ypuA-3ooiA:
26.4		 4ypuA-3ooiA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 11 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.58A 4ypuB-3ooiA:
24.4		 4ypuB-3ooiA:
40.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		3 / 3 ARG A 133
LYS A 161
GLU A 123
 None
 0.75A 5d0yA-3ooiA:
undetectable		 5d0yA-3ooiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		3 / 3 GLY A  78
GLY A  77
GLN A  83
 None
 0.48A 5imsA-3ooiA:
undetectable		 5imsA-3ooiA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.21A 5jhnA-3ooiA:
15.4		 5jhnA-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.33A 5jhnA-3ooiA:
15.4		 5jhnA-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.25A 5jhnB-3ooiA:
19.2		 5jhnB-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.27A 5jhnB-3ooiA:
19.2		 5jhnB-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.33A 5jhnB-3ooiA:
19.2		 5jhnB-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.36A 5jinA-3ooiA:
15.5		 5jinA-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.43A 5jinA-3ooiA:
15.5		 5jinA-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.14A 5jinB-3ooiA:
19.3		 5jinB-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.34A 5jinB-3ooiA:
19.3		 5jinB-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.22A 5jiyA-3ooiA:
18.9		 5jiyA-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.33A 5jiyA-3ooiA:
18.9		 5jiyA-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.26A 5jiyB-3ooiA:
19.2		 5jiyB-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.34A 5jiyB-3ooiA:
19.2		 5jiyB-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.34A 5jj0A-3ooiA:
15.5		 5jj0A-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.40A 5jj0A-3ooiA:
15.5		 5jj0A-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.32A 5jj0B-3ooiA:
19.2		 5jj0B-3ooiA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.28A 5jj0B-3ooiA:
19.2		 5jj0B-3ooiA:
30.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
ASN A 169
HIS A 170
TYR A 207
LEU A 230
 SAM  A 237 ( 3.7A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
SAM  A 237 (-4.8A)
 0.93A 5kklB-3ooiA:
4.5		 5kklB-3ooiA:
13.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		10 / 12 ARG A 101
GLY A 102
TRP A 103
TYR A 146
HIS A 170
ASN A 214
THR A 217
CYH A 219
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
SAM  A 237 (-2.6A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.72A 5lsuA-3ooiA:
33.7		 5lsuA-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 TRP A 103
TYR A 146
ASN A 214
CYH A 171
LEU A 230
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-2.6A)
None
SAM  A 237 (-4.8A)
 1.43A 5lsuA-3ooiA:
33.7		 5lsuA-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		10 / 12 ARG A 101
GLY A 102
TRP A 103
PHE A 145
TYR A 146
HIS A 170
ASN A 214
THR A 217
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
SAM  A 237 (-2.6A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.90A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 TRP A 103
PHE A 145
TYR A 146
ASN A 214
CYH A 171
 None
None
SAM  A 237 (-4.1A)
SAM  A 237 (-2.6A)
None
 1.46A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		3 / 3 ASN A 169
TYR A 207
CYH A 219
 SAM  A 237 (-3.3A)
None
ZN  A 232 ( 2.3A)
 0.10A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.29A 5t0kA-3ooiA:
19.2		 5t0kA-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.31A 5t0kA-3ooiA:
19.2		 5t0kA-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.22A 5t0kA-3ooiA:
19.2		 5t0kA-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.24A 5t0kB-3ooiA:
19.6		 5t0kB-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.29A 5t0kB-3ooiA:
19.6		 5t0kB-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.08A 5t0mA-3ooiA:
19.5		 5t0mA-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.30A 5t0mA-3ooiA:
19.5		 5t0mA-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.21A 5t0mB-3ooiA:
19.0		 5t0mB-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.29A 5t0mB-3ooiA:
19.0		 5t0mB-3ooiA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.35A 5t0mB-3ooiA:
19.0		 5t0mB-3ooiA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 10 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.35A 5tegB-3ooiA:
14.3
5tegE-3ooiA:
undetectable		 5tegB-3ooiA:
23.53
5tegE-3ooiA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 10 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.26A 5tqrB-3ooiA:
4.2		 5tqrB-3ooiA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 11 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.27A 5ttfA-3ooiA:
18.8		 5ttfA-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.37A 5ttfA-3ooiA:
18.8		 5ttfA-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.29A 5ttfB-3ooiA:
18.9		 5ttfB-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.40A 5ttfB-3ooiA:
18.9		 5ttfB-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.55A 5ttfC-3ooiA:
19.0		 5ttfC-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.46A 5ttfD-3ooiA:
15.5		 5ttfD-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.49A 5ttfD-3ooiA:
15.5		 5ttfD-3ooiA:
29.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.40A 5ttgA-3ooiA:
15.9		 5ttgA-3ooiA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.40A 5ttgA-3ooiA:
15.9		 5ttgA-3ooiA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.42A 5ttgB-3ooiA:
15.5		 5ttgB-3ooiA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.44A 5ttgB-3ooiA:
15.5		 5ttgB-3ooiA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.37A 5tuyA-3ooiA:
18.9		 5tuyA-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.50A 5tuyA-3ooiA:
18.9		 5tuyA-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.34A 5tuyA-3ooiA:
18.9		 5tuyA-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.38A 5tuyB-3ooiA:
15.4		 5tuyB-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.45A 5tuyB-3ooiA:
15.4		 5tuyB-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.33A 5tuyB-3ooiA:
15.4		 5tuyB-3ooiA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.41A 5tuzA-3ooiA:
15.9		 5tuzA-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.39A 5tuzB-3ooiA:
15.7		 5tuzB-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.40A 5tuzB-3ooiA:
15.7		 5tuzB-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		11 / 11 ARG A 101
GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.40A 5updA-3ooiA:
32.0		 5updA-3ooiA:
76.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
CYH A 171
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
None
SAM  A 237 (-4.8A)
 1.25A 5updA-3ooiA:
32.0		 5updA-3ooiA:
76.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 11 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.16A 5updA-3ooiA:
32.0		 5updA-3ooiA:
76.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.09A 5v21A-3ooiA:
24.7		 5v21A-3ooiA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
SAM  A 237 (-4.8A)
 0.57A 5v21A-3ooiA:
24.7		 5v21A-3ooiA:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.27A 5v9iA-3ooiA:
18.7		 5v9iA-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.49A 5v9iA-3ooiA:
18.7		 5v9iA-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.43A 5v9iA-3ooiA:
18.7		 5v9iA-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.41A 5v9iB-3ooiA:
18.9		 5v9iB-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.43A 5v9iB-3ooiA:
18.9		 5v9iB-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.46A 5v9iC-3ooiA:
18.8		 5v9iC-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.49A 5v9iC-3ooiA:
18.8		 5v9iC-3ooiA:
29.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.57A 5v9iD-3ooiA:
18.9		 5v9iD-3ooiA:
29.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.37A 5v9jA-3ooiA:
15.9		 5v9jA-3ooiA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.37A 5v9jA-3ooiA:
15.9		 5v9jA-3ooiA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.42A 5v9jB-3ooiA:
19.3		 5v9jB-3ooiA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.41A 5v9jB-3ooiA:
19.3		 5v9jB-3ooiA:
31.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 10 VAL A 121
GLY A 162
GLY A 159
LEU A 150
ILE A 125
LEU A 124
 None
 1.15A 5vm8B-3ooiA:
undetectable		 5vm8B-3ooiA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.21A 5vscA-3ooiA:
19.0		 5vscA-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.41A 5vscA-3ooiA:
19.0		 5vscA-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.34A 5vscA-3ooiA:
19.0		 5vscA-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.21A 5vscB-3ooiA:
15.2		 5vscB-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.40A 5vscB-3ooiA:
15.2		 5vscB-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.39A 5vscB-3ooiA:
15.2		 5vscB-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.41A 5vsdA-3ooiA:
10.8		 5vsdA-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.40A 5vsdA-3ooiA:
10.8		 5vsdA-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.42A 5vsdB-3ooiA:
15.9		 5vsdB-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.44A 5vsdB-3ooiA:
15.9		 5vsdB-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.23A 5vseA-3ooiA:
19.0		 5vseA-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.35A 5vseA-3ooiA:
19.0		 5vseA-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.35A 5vseA-3ooiA:
19.0		 5vseA-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.21A 5vseB-3ooiA:
18.7		 5vseB-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
GLN A 100
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SO4  A 235 (-3.8A)
 1.39A 5vseB-3ooiA:
18.7		 5vseB-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.37A 5vseB-3ooiA:
18.7		 5vseB-3ooiA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.41A 5vsfA-3ooiA:
15.8		 5vsfA-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.42A 5vsfA-3ooiA:
15.8		 5vsfA-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.39A 5vsfB-3ooiA:
15.9		 5vsfB-3ooiA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
 0.38A 5vsfB-3ooiA:
15.9		 5vsfB-3ooiA:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 ARG A 101
GLY A 102
ASN A 169
HIS A 170
TYR A 207
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
 0.84A 5xxdA-3ooiA:
5.3		 5xxdA-3ooiA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		4 / 7 THR A 178
ILE A 156
THR A 149
TYR A 207
 None
 1.02A 5zsfA-3ooiA:
undetectable
5zsfB-3ooiA:
undetectable		 5zsfA-3ooiA:
17.41
5zsfB-3ooiA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 ARG A 101
GLY A 102
TRP A 103
ASN A 169
HIS A 170
CYH A 219
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.87A 6a5kA-3ooiA:
14.7		 6a5kA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 ARG A 101
GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.60A 6a5kA-3ooiA:
14.7		 6a5kA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 ARG A 101
GLY A 104
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SO4  A 235 ( 4.0A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 1.32A 6a5kA-3ooiA:
14.7		 6a5kA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
ASN A 169
CYH A 171
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
None
SAM  A 237 (-4.8A)
 1.38A 6a5kA-3ooiA:
14.7		 6a5kA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.36A 6a5kA-3ooiA:
14.7		 6a5kA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		9 / 12 ARG A 101
GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
CYH A 219
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.77A 6a5mA-3ooiA:
16.4		 6a5mA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		9 / 12 ARG A 101
GLY A 102
TRP A 103
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.53A 6a5mA-3ooiA:
16.4		 6a5mA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
TRP A 103
ASN A 169
CYH A 171
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
None
SAM  A 237 (-4.8A)
 1.34A 6a5mA-3ooiA:
16.4		 6a5mA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.39A 6a5mA-3ooiA:
16.4		 6a5mA-3ooiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.01A 6a5mA-3ooiA:
16.4		 6a5mA-3ooiA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 GLY A 102
TRP A 103
ASN A 169
HIS A 170
CYH A 219
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
ZN  A 232 ( 2.3A)
 1.46A 6agoA-3ooiA:
25.0		 6agoA-3ooiA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.93A 6agoA-3ooiA:
25.0		 6agoA-3ooiA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.82A 6agoA-3ooiA:
25.0		 6agoA-3ooiA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 11 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.50A 6agoA-3ooiA:
25.0		 6agoA-3ooiA:
43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
HIS A 170
LYS A 220
CYH A 221
LEU A 230
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.85A 6bp4A-3ooiA:
18.8		 6bp4A-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 102
HIS A 170
TYR A 207
LYS A 220
CYH A 221
 SAM  A 237 ( 3.7A)
SAM  A 237 (-4.7A)
None
None
ZN  A 232 (-2.3A)
 0.63A 6bp4A-3ooiA:
18.8		 6bp4A-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ARG A 166
HIS A 170
CYH A 221
LEU A 230
 SAM  A 237 ( 3.7A)
None
None
SAM  A 237 (-4.7A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.84A 6bp4A-3ooiA:
18.8		 6bp4A-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
ARG A 166
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
None
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 0.63A 6bp4A-3ooiA:
18.8		 6bp4A-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
CYH A 219
CYH A 221
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.76A 6bp4B-3ooiA:
19.5		 6bp4B-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.38A 6bp4B-3ooiA:
19.5		 6bp4B-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 GLY A 102
TRP A 103
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.32A 6bp4B-3ooiA:
19.5		 6bp4B-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 0.87A 6bp4B-3ooiA:
19.5		 6bp4B-3ooiA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		5 / 12 GLY A 104
TYR A 146
HIS A 170
TYR A 207
CYH A 221
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.44A 6bp4B-3ooiA:
19.5		 6bp4B-3ooiA:
27.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		10 / 11 ARG A 101
GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
HIS A 170
CYH A 219
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.67A 6cenA-3ooiA:
32.8		 6cenA-3ooiA:
76.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		10 / 11 ARG A 101
GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
CYH A 221
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
 0.34A 6cenA-3ooiA:
32.8		 6cenA-3ooiA:
76.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		7 / 11 GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
CYH A 171
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
None
SAM  A 237 (-4.8A)
 1.24A 6cenA-3ooiA:
32.8		 6cenA-3ooiA:
76.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 11 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 (-2.3A)
 1.14A 6cenA-3ooiA:
32.8		 6cenA-3ooiA:
76.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		6 / 12 TRP A 103
TYR A 146
PHE A 167
ASN A 169
HIS A 170
LEU A 230
 None
SAM  A 237 (-4.1A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
SAM  A 237 (-4.8A)
 0.87A 6chgC-3ooiA:
10.4		 6chgC-3ooiA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC
(Homo
sapiens) 		8 / 12 GLY A 102
TRP A 103
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
CYH A 221
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
ZN  A 232 (-2.3A)
 0.53A 6ineA-3ooiA:
24.4		 6ineA-3ooiA:
41.42