SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ooq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 10 ALA A 359
ASP A 358
ASP A 381
ILE A 380
GLY A  58
 None
 1.19A 1d4sA-3ooqA:
undetectable		 1d4sA-3ooqA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 10 ALA A 359
ASP A 358
ASP A 381
ILE A 380
GLY A  58
 None
 1.13A 1d4yA-3ooqA:
undetectable		 1d4yA-3ooqA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		4 / 5 ASP A 232
GLY A 174
PRO A 124
ALA A 153
 None
 0.97A 2aohA-3ooqA:
undetectable		 2aohA-3ooqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		4 / 7 TYR A 182
GLY A 126
ASN A 123
ASP A  79
 None
 0.84A 2g72B-3ooqA:
undetectable		 2g72B-3ooqA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 11 ALA A 359
ASP A 358
ASP A 381
ILE A 380
GLY A  58
 None
 1.09A 2o4pA-3ooqA:
undetectable		 2o4pA-3ooqA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 9 THR A 290
GLU A 289
LEU A 294
LEU A 295
ILE A 301
 None
 1.40A 3nbqA-3ooqA:
undetectable		 3nbqA-3ooqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		4 / 4 LYS A 133
PHE A 134
PHE A 386
VAL A 375
 None
 1.24A 3rv5A-3ooqA:
undetectable
3rv5B-3ooqA:
undetectable		 3rv5A-3ooqA:
13.13
3rv5B-3ooqA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 9 ASN A  81
GLY A 120
ASN A 157
SER A  78
GLY A  80
 None
 1.06A 3ztvA-3ooqA:
1.4		 3ztvA-3ooqA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		4 / 7 GLY A 120
VAL A 118
ASN A  81
GLY A  67
 None
 0.81A 4forA-3ooqA:
undetectable		 4forA-3ooqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		4 / 5 GLY A 127
VAL A  91
PRO A  89
TYR A 182
 None
 1.19A 4grkA-3ooqA:
undetectable		 4grkA-3ooqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		3 / 3 LYS A   6
LEU A  27
ALA A  45
 None
 0.81A 4iizA-3ooqA:
undetectable		 4iizA-3ooqA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		4 / 8 LEU A 108
ARG A 135
SER A  64
VAL A 144
 None
 1.02A 4klrB-3ooqA:
undetectable		 4klrB-3ooqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
GLY A 120
GLY A  80
LEU A  68
ALA A 122
 None
 1.06A 4lg1A-3ooqA:
undetectable		 4lg1A-3ooqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
GLY A 120
GLY A  80
LEU A  68
ALA A 122
 None
 1.03A 4lg1B-3ooqA:
undetectable		 4lg1B-3ooqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
GLY A 120
GLY A  80
LEU A  68
ALA A 122
 None
 1.07A 4lg1C-3ooqA:
undetectable		 4lg1C-3ooqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 LEU A  94
GLY A 129
MET A 116
VAL A 115
HIS A  65
 None
 1.15A 4olmA-3ooqA:
undetectable		 4olmA-3ooqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 6 HIS A  63
HIS A  65
HIS A 226
HIS A 251
ASP A 306
 None
 0.95A 4ubpC-3ooqA:
16.5		 4ubpC-3ooqA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		4 / 4 ILE A   7
ARG A 387
TYR A 379
GLU A 384
 None
 1.32A 4zzbD-3ooqA:
undetectable		 4zzbD-3ooqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 THR A 235
LEU A 281
ALA A 227
PHE A 154
GLY A 155
 None
 1.21A 5jglA-3ooqA:
undetectable		 5jglA-3ooqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 9 ALA A 359
ASP A 358
ASP A 381
ILE A 380
GLY A  58
 None
 1.06A 5kr2A-3ooqA:
undetectable		 5kr2A-3ooqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 GLY A  52
ASP A  25
ASN A  39
ASP A  42
ASP A  49
 None
 1.20A 5yniA-3ooqA:
undetectable		 5yniA-3ooqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 GLY A  52
ASP A  25
ASN A  39
ASP A  42
ASP A  49
 None
 1.21A 5ynmA-3ooqA:
undetectable		 5ynmA-3ooqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 TYR A 182
ALA A 236
ALA A 240
LEU A 217
MET A 210
 None
 1.21A 6aybA-3ooqA:
undetectable		 6aybA-3ooqA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3ooq AMIDOHYDROLASE
(Thermotoga
maritima) 		5 / 12 TYR A 182
ALA A 236
ALA A 240
LEU A 217
MET A 210
 None
 1.20A 6aycA-3ooqA:
undetectable		 6aycA-3ooqA:
14.94