SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3op0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		4 / 6 SER A  61
VAL A  58
GLY A 142
GLU A 134
 None
None
None
NA  A   2 ( 4.9A)
 0.89A 1fduD-3op0A:
undetectable		 1fduD-3op0A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		4 / 6 TYR A 244
GLY A 282
SER A 279
ARG A 255
 None
 1.39A 2a3cA-3op0A:
undetectable		 2a3cA-3op0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		4 / 6 TYR A 244
GLY A 282
SER A 279
ARG A 255
 None
 1.40A 2a3cB-3op0A:
undetectable		 2a3cB-3op0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		5 / 9 GLU A  13
LEU A  55
LEU A  80
ALA A  85
ALA A  17
 None
 1.36A 2bxcB-3op0A:
undetectable		 2bxcB-3op0A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		5 / 12 LEU A 322
HIS A 183
PRO A 220
THR A 215
LEU A 231
 None
CSO  A 182 ( 3.9A)
None
None
None
 1.31A 3okxB-3op0A:
undetectable		 3okxB-3op0A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		3 / 3 ASN A 291
ALA A 290
LYS A 292
 None
 0.95A 3runA-3op0A:
undetectable		 3runA-3op0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		4 / 8 THR A 223
LEU A 319
LEU A 322
GLY A 323
 None
 0.87A 4c9nA-3op0A:
undetectable		 4c9nA-3op0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		3 / 3 SER A  40
ASP A 245
GLN A 286
 None
 0.94A 4oltA-3op0A:
undetectable
4oltB-3op0A:
0.8		 4oltA-3op0A:
20.92
4oltB-3op0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		4 / 4 THR A 268
LEU A 270
HIS A 130
GLY A 271
 None
 1.43A 5gwyA-3op0A:
undetectable		 5gwyA-3op0A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		5 / 12 ASP A 245
GLU A 246
LEU A  48
ARG A  45
LEU A 121
 None
 1.35A 5nd2B-3op0A:
undetectable		 5nd2B-3op0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens) 		5 / 12 LEU A 194
PRO A 184
PHE A 175
SER A 163
THR A 215
 None
 1.22A 6debB-3op0A:
undetectable		 6debB-3op0A:
12.50