SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3op1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 LEU A 212
ALA A 252
PHE A 254
VAL A 241
 None
 0.86A 1epbB-3op1A:
undetectable		 1epbB-3op1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 THR A 207
SER A 240
ARG A 279
LEU A 290
ASP A 297
 None
 0.94A 1nb9A-3op1A:
13.2		 1nb9A-3op1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 HIS A  30
GLY A  32
HIS A  33
GLY A 126
VAL A 155
 SO4  A 311 (-4.1A)
GOL  A 312 (-3.3A)
SO4  A 311 (-4.3A)
GOL  A 312 (-3.6A)
GOL  A 312 (-4.2A)
 0.63A 1pg2A-3op1A:
5.0		 1pg2A-3op1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A  30
GLY A  32
HIS A  33
GLY A 126
VAL A 155
 SO4  A 311 (-4.1A)
GOL  A 312 (-3.3A)
SO4  A 311 (-4.3A)
GOL  A 312 (-3.6A)
GOL  A 312 (-4.2A)
 0.89A 1qu2A-3op1A:
undetectable		 1qu2A-3op1A:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 THR A 207
VAL A 223
GLU A 255
ARG A 279
ASP A 297
 None
 0.48A 1t6zA-3op1A:
25.3		 1t6zA-3op1A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 THR A 246
VAL A 194
VAL A 211
ASN A 209
GLU A 255
 None
 1.23A 1t6zA-3op1A:
25.3		 1t6zA-3op1A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 THR A 207
VAL A 223
ARG A 279
LEU A 290
ASP A 297
 None
 0.84A 1t6zB-3op1A:
25.9		 1t6zB-3op1A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 THR A 246
VAL A 194
VAL A 211
ASN A 209
GLU A 255
 None
 1.31A 1t6zB-3op1A:
25.9		 1t6zB-3op1A:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  13
ALA A 120
LEU A  23
ILE A 123
PHE A 102
 None
None
GOL  A 318 ( 4.5A)
None
None
 1.08A 2h79A-3op1A:
undetectable		 2h79A-3op1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A  76
ASN A  77
LEU A  73
TYR A 273
 None
 1.19A 2w8yA-3op1A:
undetectable		 2w8yA-3op1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 HIS A  30
GLY A  32
HIS A  33
GLY A 126
ASP A 128
 SO4  A 311 (-4.1A)
GOL  A 312 (-3.3A)
SO4  A 311 (-4.3A)
GOL  A 312 (-3.6A)
None
 1.18A 2x1lA-3op1A:
3.5		 2x1lA-3op1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 141
ILE A 115
ILE A 123
PHE A 102
PHE A  56
 None
None
None
None
GOL  A 318 ( 4.9A)
 1.13A 2ygpA-3op1A:
undetectable		 2ygpA-3op1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLN A 101
PHE A 102
PHE A  98
LEU A  64
 None
 1.08A 3ablP-3op1A:
undetectable
3ablW-3op1A:
undetectable		 3ablP-3op1A:
19.18
3ablW-3op1A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 VAL A  21
VAL A  22
PHE A 131
ARG A  81
 None
 1.18A 3bjwH-3op1A:
undetectable		 3bjwH-3op1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 VAL A  21
VAL A  22
PHE A 131
ARG A  81
 None
 1.06A 3bjwF-3op1A:
undetectable		 3bjwF-3op1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A  24
ILE A  51
MET A 118
LEU A  93
LEU A  85
 GOL  A 318 (-3.6A)
None
None
None
None
 1.20A 3cs8A-3op1A:
undetectable		 3cs8A-3op1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  13
ALA A 120
LEU A  23
ILE A 123
PHE A 102
 None
None
GOL  A 318 ( 4.5A)
None
None
 1.07A 3uvvA-3op1A:
undetectable		 3uvvA-3op1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ILE A  51
ILE A 122
ILE A 123
TYR A 144
ILE A 150
 None
 0.94A 3zosA-3op1A:
undetectable		 3zosA-3op1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A  30
GLY A  32
LEU A  36
GLY A 126
ASP A 128
 SO4  A 311 (-4.1A)
GOL  A 312 (-3.3A)
GOL  A 312 ( 4.8A)
GOL  A 312 (-3.6A)
None
 1.11A 5hg0A-3op1A:
9.8		 5hg0A-3op1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		6 / 12 HIS A  30
GLY A  32
HIS A  33
LEU A  36
GLY A 126
ASP A 128
 SO4  A 311 (-4.1A)
GOL  A 312 (-3.3A)
SO4  A 311 (-4.3A)
GOL  A 312 ( 4.8A)
GOL  A 312 (-3.6A)
None
 1.05A 5hg0B-3op1A:
9.8		 5hg0B-3op1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A 102
LEU A  23
LEU A  96
THR A 113
ALA A 117
 None
GOL  A 318 ( 4.5A)
None
None
None
 1.22A 5ienB-3op1A:
undetectable		 5ienB-3op1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 VAL A 256
ILE A 258
VAL A 226
ALA A 237
 None
 0.70A 5ospA-3op1A:
undetectable		 5ospA-3op1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 VAL A 256
ILE A 258
VAL A 226
ALA A 237
 None
 0.67A 5osrA-3op1A:
undetectable		 5osrA-3op1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A  63
PRO A  66
ALA A 103
PRO A  60
PHE A  98
 None
PEG  A 314 (-3.6A)
None
None
None
 1.22A 5zvgA-3op1A:
undetectable		 5zvgA-3op1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A  63
PRO A  66
ALA A 103
PRO A  60
PHE A  98
 None
PEG  A 314 (-3.6A)
None
None
None
 1.22A 5zvgB-3op1A:
undetectable		 5zvgB-3op1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLY A  24
HIS A  33
SER A 163
SER A 164
 GOL  A 318 (-3.6A)
SO4  A 311 (-4.3A)
SO4  A 311 (-4.8A)
SO4  A 311 (-2.9A)
 0.64A 6jmjA-3op1A:
8.4		 6jmjA-3op1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		5 / 7 GLY A  24
PHE A  26
HIS A  33
SER A 163
SER A 164
 GOL  A 318 (-3.6A)
None
SO4  A 311 (-4.3A)
SO4  A 311 (-4.8A)
SO4  A 311 (-2.9A)
 0.71A 6jnhA-3op1A:
7.8		 6jnhA-3op1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3op1 MACROLIDE-EFFLUX
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLY A  24
HIS A  33
SER A 163
SER A 164
 GOL  A 318 (-3.6A)
SO4  A 311 (-4.3A)
SO4  A 311 (-4.8A)
SO4  A 311 (-2.9A)
 0.68A 6jogA-3op1A:
8.4		 6jogA-3op1A:
22.98