SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3opb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 119
GLY A 117
PHE A  44
LEU A  75
ALA A 100
 None
 1.49A 1e3vB-3opbA:
undetectable		 1e3vB-3opbA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 104
SER A  90
ILE A  93
LEU A 128
 None
 0.62A 1eupA-3opbA:
undetectable		 1eupA-3opbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 231
SER A 243
PHE A 246
LEU A 247
TYR A 287
 None
 1.33A 1mmkA-3opbA:
undetectable		 1mmkA-3opbA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 231
SER A 243
PHE A 246
LEU A 247
TYR A 287
 None
 1.34A 1mmtA-3opbA:
undetectable		 1mmtA-3opbA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 548
GLU A 547
THR A 553
ILE A 566
 None
 1.03A 1qvtA-3opbA:
2.1		 1qvtA-3opbA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 192
PHE A 189
ALA A 190
LEU A 155
 None
 1.01A 1ukbA-3opbA:
undetectable		 1ukbA-3opbA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 SER A 277
LEU A 274
MET A 185
SER A 237
ILE A 176
 None
 1.42A 1uobA-3opbA:
undetectable		 1uobA-3opbA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.92A 1v54P-3opbA:
undetectable
1v54W-3opbA:
undetectable		 1v54P-3opbA:
14.10
1v54W-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.95A 1v55C-3opbA:
undetectable
1v55J-3opbA:
undetectable		 1v55C-3opbA:
14.10
1v55J-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.91A 1v55P-3opbA:
undetectable
1v55W-3opbA:
undetectable		 1v55P-3opbA:
14.10
1v55W-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 693
ILE A 694
ILE A 698
PHE A 718
LEU A 721
 None
 0.72A 1xdkB-3opbA:
undetectable		 1xdkB-3opbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 693
ILE A 694
ILE A 698
PHE A 718
LEU A 721
 None
 0.71A 1xdkF-3opbA:
undetectable		 1xdkF-3opbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 545
GLY A 589
ALA A 541
ILE A 542
 None
 0.64A 2aohB-3opbA:
undetectable		 2aohB-3opbA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  86
SER A  83
SER A  85
GLU A  84
 None
 1.29A 2c8aA-3opbA:
undetectable		 2c8aA-3opbA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  86
SER A  83
SER A  85
GLU A  84
 None
 1.28A 2c8aC-3opbA:
undetectable		 2c8aC-3opbA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.96A 2dysC-3opbA:
undetectable
2dysJ-3opbA:
undetectable		 2dysC-3opbA:
14.10
2dysJ-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.95A 2dysP-3opbA:
undetectable
2dysW-3opbA:
undetectable		 2dysP-3opbA:
14.10
2dysW-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.93A 2eijC-3opbA:
undetectable
2eijJ-3opbA:
undetectable		 2eijC-3opbA:
14.10
2eijJ-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.91A 2eijP-3opbA:
undetectable
2eijW-3opbA:
undetectable		 2eijP-3opbA:
14.10
2eijW-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.92A 2eikC-3opbA:
undetectable
2eikJ-3opbA:
undetectable		 2eikC-3opbA:
14.10
2eikJ-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.90A 2eikP-3opbA:
undetectable
2eikW-3opbA:
undetectable		 2eikP-3opbA:
14.10
2eikW-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.94A 2eimC-3opbA:
undetectable
2eimJ-3opbA:
undetectable		 2eimC-3opbA:
14.10
2eimJ-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.92A 2einC-3opbA:
undetectable
2einJ-3opbA:
undetectable		 2einC-3opbA:
14.10
2einJ-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.87A 2einP-3opbA:
undetectable
2einW-3opbA:
undetectable		 2einP-3opbA:
14.10
2einW-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 657
LEU A 654
LEU A 648
MET A 610
 None
 1.08A 2oaxF-3opbA:
undetectable		 2oaxF-3opbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 254
ARG A 258
ILE A 227
PHE A 267
ASP A 222
 None
 1.26A 2q6hA-3opbA:
undetectable		 2q6hA-3opbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 714
PHE A 701
ALA A 702
GLU A 739
LEU A 747
 None
 1.41A 2v0mA-3opbA:
undetectable		 2v0mA-3opbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 714
PHE A 701
ALA A 702
GLU A 739
LEU A 747
 None
 1.39A 2v0mD-3opbA:
undetectable		 2v0mD-3opbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 698
LEU A 715
PHE A 718
PHE A 722
 None
 0.97A 2vctD-3opbA:
3.4		 2vctD-3opbA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 356
LEU A 300
VAL A 314
ILE A 307
PHE A 334
 None
 1.03A 2w9hA-3opbA:
undetectable		 2w9hA-3opbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 THR A 521
ARG A 481
LEU A 502
ASP A 556
 None
 0.90A 2zw9A-3opbA:
undetectable		 2zw9A-3opbA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.91A 2zxwC-3opbA:
undetectable
2zxwJ-3opbA:
undetectable		 2zxwC-3opbA:
14.10
2zxwJ-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.94A 2zxwP-3opbA:
undetectable
2zxwW-3opbA:
undetectable		 2zxwP-3opbA:
14.10
2zxwW-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 529
LEU A 545
LEU A 539
ILE A 542
THR A 599
 None
 1.19A 3a50E-3opbA:
2.1		 3a50E-3opbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.98A 3ag1C-3opbA:
undetectable
3ag1J-3opbA:
undetectable		 3ag1C-3opbA:
14.10
3ag1J-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.90A 3ag4P-3opbA:
undetectable
3ag4W-3opbA:
undetectable		 3ag4P-3opbA:
14.10
3ag4W-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 356
LEU A 300
VAL A 314
ILE A 307
PHE A 334
 None
 1.05A 3frbX-3opbA:
undetectable		 3frbX-3opbA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 322
GLN A 294
LEU A 296
GLU A 297
 None
 1.10A 3h5gB-3opbA:
undetectable
3h5gC-3opbA:
undetectable		 3h5gB-3opbA:
3.58
3h5gC-3opbA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 SER A 368
ARG A 367
ALA A 435
ALA A 436
 None
 1.00A 3ns1L-3opbA:
undetectable		 3ns1L-3opbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 6 PHE A 533
ALA A 541
ALA A 577
LEU A 520
THR A 521
 None
 1.43A 4dtzA-3opbA:
undetectable		 4dtzA-3opbA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 MET A 208
LEU A 211
ILE A 173
ILE A 176
LEU A 231
 None
 0.96A 4j24A-3opbA:
undetectable		 4j24A-3opbA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 MET A 208
LEU A 211
ILE A 173
ILE A 176
LEU A 231
 None
 0.93A 4j24B-3opbA:
undetectable		 4j24B-3opbA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 391
VAL A 394
ILE A 395
TYR A 355
LEU A 358
 None
 0.97A 4pd4C-3opbA:
undetectable		 4pd4C-3opbA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 546
THR A 634
LEU A 624
 None
 0.71A 4qztA-3opbA:
undetectable		 4qztA-3opbA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 578
THR A 621
LEU A 624
THR A 605
 None
 0.77A 4z90A-3opbA:
undetectable
4z90B-3opbA:
undetectable
4z90C-3opbA:
undetectable
4z90D-3opbA:
undetectable
4z90E-3opbA:
undetectable		 4z90A-3opbA:
17.39
4z90B-3opbA:
17.39
4z90C-3opbA:
17.39
4z90D-3opbA:
17.39
4z90E-3opbA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 592
LEU A 624
LEU A 581
LEU A 578
PHE A 546
 None
 1.24A 4zmeB-3opbA:
undetectable		 4zmeB-3opbA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  71
LEU A  59
ILE A  43
LEU A  46
 None
 0.79A 4zvcA-3opbA:
undetectable
4zvcB-3opbA:
undetectable		 4zvcA-3opbA:
10.96
4zvcB-3opbA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.97A 5b1bP-3opbA:
undetectable
5b1bW-3opbA:
undetectable		 5b1bP-3opbA:
14.10
5b1bW-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 535
ASP A 588
TYR A 536
LEU A 499
 None
 1.29A 5bmvB-3opbA:
undetectable		 5bmvB-3opbA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 476
GLY A 493
ILE A 525
ARG A 522
LEU A 545
 None
 0.99A 5e72A-3opbA:
undetectable		 5e72A-3opbA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 581
LEU A 539
PHE A 533
LEU A 499
 None
 0.92A 5gs4A-3opbA:
undetectable		 5gs4A-3opbA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 335
ILE A 375
MET A 365
 None
 0.62A 5i9yA-3opbA:
undetectable		 5i9yA-3opbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.98A 5iy5C-3opbA:
undetectable
5iy5J-3opbA:
undetectable		 5iy5C-3opbA:
13.94
5iy5J-3opbA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 MET A 185
ALA A 190
LEU A 172
ILE A 173
CYH A 242
 None
 1.22A 5vlmB-3opbA:
1.3		 5vlmB-3opbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 MET A 185
ALA A 190
LEU A 172
ILE A 173
CYH A 242
 None
 1.24A 5vlmE-3opbA:
2.2		 5vlmE-3opbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 340
MET A 379
THR A 378
LEU A 376
 None
 1.43A 5z86J-3opbA:
undetectable		 5z86J-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.93A 5zcqC-3opbA:
undetectable
5zcqJ-3opbA:
undetectable		 5zcqC-3opbA:
14.10
5zcqJ-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 9 MET A 396
PHE A 456
SER A 455
LEU A 457
ILE A 475
 None
 1.15A 6fdyU-3opbA:
undetectable		 6fdyU-3opbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  79
ASP A  81
GLN A  80
 None
 0.94A 6g1pA-3opbA:
undetectable		 6g1pA-3opbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 340
MET A 379
THR A 378
LEU A 376
 None
 1.28A 6nknW-3opbA:
undetectable		 6nknW-3opbA:
5.23