SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ope'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		3 / 3 PRO A2123
THR A2121
PRO A2119
 None
 0.75A 2d55C-3opeA:
undetectable		 2d55C-3opeA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.59A 2r3aA-3opeA:
18.6		 2r3aA-3opeA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 TYR A2194
HIS A2218
TYR A2255
CYH A2268
LYS A2269
CYH A2270
 SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
None
ZN  A   1 (-2.7A)
 0.94A 2r3aA-3opeA:
18.6		 2r3aA-3opeA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		4 / 8 GLY A2163
TRP A2229
PHE A2114
TYR A2240
 None
 1.37A 3ccfA-3opeA:
undetectable		 3ccfA-3opeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2248
ILE A2154
GLY A2153
PRO A2246
THR A2252
 None
 1.10A 3eeyD-3opeA:
undetectable		 3eeyD-3opeA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		9 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
LYS A2269
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
ZN  A   1 (-2.7A)
 0.46A 3ooiA-3opeA:
26.0		 3ooiA-3opeA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.39A 3ooiA-3opeA:
26.0		 3ooiA-3opeA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
None
 1.41A 3opeA-3opeA:
38.6		 3opeA-3opeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.27A 3opeA-3opeA:
38.6		 3opeA-3opeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		12 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.00A 3opeA-3opeA:
38.6		 3opeA-3opeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		9 / 9 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
TYR A2255
GLN A2266
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
SAM  A   7 (-2.9A)
None
 0.72A 3opeB-3opeA:
30.1		 3opeB-3opeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.86A 3qxyA-3opeA:
6.4		 3qxyA-3opeA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.82A 3rc0B-3opeA:
6.3		 3rc0B-3opeA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.48A 3rq4A-3opeA:
9.4		 3rq4A-3opeA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.53A 3s8pA-3opeA:
8.6		 3s8pA-3opeA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.53A 4bupA-3opeA:
8.4		 4bupA-3opeA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 10 LYS A2150
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.65A 4ij8A-3opeA:
12.9
4ij8B-3opeA:
12.8		 4ij8A-3opeA:
23.77
4ij8B-3opeA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_B_SAMB501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 9 LYS A2150
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.67A 4ij8A-3opeA:
12.9
4ij8B-3opeA:
12.8		 4ij8A-3opeA:
23.77
4ij8B-3opeA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
None
None
ZN  A   1 ( 2.5A)
None
 1.17A 4ynmA-3opeA:
34.2		 4ynmA-3opeA:
98.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		11 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.50A 4ynmA-3opeA:
34.2		 4ynmA-3opeA:
98.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 LYS A2150
GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.34A 4ynmA-3opeA:
34.2		 4ynmA-3opeA:
98.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
HIS A2193
ASN A2217
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
 1.22A 4ynmA-3opeA:
34.2		 4ynmA-3opeA:
98.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		11 / 12 GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.52A 4ynmB-3opeA:
31.2		 4ynmB-3opeA:
98.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.36A 4ynmB-3opeA:
31.2		 4ynmB-3opeA:
98.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 HIS A2193
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
 1.33A 4ynmB-3opeA:
31.2		 4ynmB-3opeA:
98.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
CYH A2270
ILE A2279
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
None
 1.39A 4ynpA-3opeA:
34.1		 4ynpA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 0.93A 4ynpA-3opeA:
34.1		 4ynpA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		11 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
HIS A2218
TYR A2255
CYH A2268
LYS A2269
CYH A2270
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
None
ZN  A   1 (-2.7A)
None
 0.51A 4ynpA-3opeA:
34.1		 4ynpA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.42A 4ynpA-3opeA:
34.1		 4ynpA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		9 / 12 LYS A2150
TRP A2152
HIS A2193
TYR A2194
HIS A2218
TYR A2255
CYH A2268
CYH A2270
ILE A2279
 None
None
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
None
 1.11A 4ynpA-3opeA:
34.1		 4ynpA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		10 / 10 GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
ILE A2279
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
 0.59A 4ynpB-3opeA:
29.4		 4ynpB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 10 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.29A 4ynpB-3opeA:
29.4		 4ynpB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 10 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
None
 1.28A 4ynpB-3opeA:
29.4		 4ynpB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 10 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.03A 4ynpB-3opeA:
29.4		 4ynpB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
 1.42A 4ypaA-3opeA:
33.3		 4ypaA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.30A 4ypaA-3opeA:
33.3		 4ypaA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		12 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.52A 4ypaA-3opeA:
33.3		 4ypaA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		11 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.61A 4ypaB-3opeA:
31.8		 4ypaB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.28A 4ypaC-3opeA:
32.8		 4ypaC-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		11 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.51A 4ypaC-3opeA:
32.8		 4ypaC-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
HIS A2193
ASN A2217
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
 1.12A 4ypaC-3opeA:
32.8		 4ypaC-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		11 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
None
 0.54A 4ypaD-3opeA:
31.4		 4ypaD-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.23A 4ypaD-3opeA:
31.4		 4ypaD-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 12 ASP A2192
TYR A2194
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.95A 4ypeA-3opeA:
33.0		 4ypeA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
ASP A2192
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 0.94A 4ypeA-3opeA:
33.0		 4ypeA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2153
ASP A2192
TYR A2194
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
None
 1.27A 4ypeA-3opeA:
33.0		 4ypeA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.29A 4ypeA-3opeA:
33.0		 4ypeA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		11 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
None
 0.51A 4ypeA-3opeA:
33.0		 4ypeA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 11 ASP A2192
HIS A2218
TYR A2255
CYH A2268
LYS A2269
ILE A2279
 SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
None
 1.14A 4ypeB-3opeA:
31.1		 4ypeB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 11 GLY A2153
ASP A2192
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
 1.15A 4ypeB-3opeA:
31.1		 4ypeB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2153
ASP A2192
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 0.96A 4ypeB-3opeA:
31.1		 4ypeB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 11 LYS A2150
ASN A2217
HIS A2218
TYR A2255
CYH A2268
LYS A2269
ILE A2279
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
None
 0.83A 4ypeB-3opeA:
31.1		 4ypeB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 11 LYS A2150
GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.42A 4ypeB-3opeA:
31.1		 4ypeB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		9 / 11 LYS A2150
GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
 0.40A 4ypeB-3opeA:
31.1		 4ypeB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
 1.35A 4ypuA-3opeA:
33.5		 4ypuA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 0.99A 4ypuA-3opeA:
33.5		 4ypuA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		10 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
 0.45A 4ypuA-3opeA:
33.5		 4ypuA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		9 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2270
LYS A2269
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
None
 1.40A 4ypuA-3opeA:
33.5		 4ypuA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		10 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
 0.60A 4ypuA-3opeA:
33.5		 4ypuA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 12 LYS A2150
TRP A2152
HIS A2193
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 None
None
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 1.19A 4ypuA-3opeA:
33.5		 4ypuA-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		9 / 11 LYS A2150
GLY A2151
TRP A2152
ASP A2192
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
 0.59A 4ypuB-3opeA:
29.1		 4ypuB-3opeA:
97.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 11 LYS A2150
HIS A2193
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 None
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 1.16A 4ypuB-3opeA:
29.1		 4ypuB-3opeA:
97.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 PHE A2215
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 None
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 1.34A 5cprB-3opeA:
7.4		 5cprB-3opeA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		4 / 6 HIS A2258
LEU A2196
CYH A2224
LEU A2239
 None
 1.41A 5hrqD-3opeA:
undetectable
5hrqG-3opeA:
undetectable
5hrqH-3opeA:
undetectable		 5hrqD-3opeA:
16.98
5hrqG-3opeA:
8.14
5hrqH-3opeA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.19A 5jhnA-3opeA:
14.4		 5jhnA-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.40A 5jhnA-3opeA:
14.4		 5jhnA-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.22A 5jhnB-3opeA:
17.7		 5jhnB-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.41A 5jhnB-3opeA:
17.7		 5jhnB-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.28A 5jinA-3opeA:
14.4		 5jinA-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
 0.40A 5jinA-3opeA:
14.4		 5jinA-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.10A 5jinB-3opeA:
17.8		 5jinB-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.41A 5jinB-3opeA:
17.8		 5jinB-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.20A 5jiyA-3opeA:
17.3		 5jiyA-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.42A 5jiyA-3opeA:
17.3		 5jiyA-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.24A 5jiyB-3opeA:
17.7		 5jiyB-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.43A 5jiyB-3opeA:
17.7		 5jiyB-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.27A 5jj0A-3opeA:
14.4		 5jj0A-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
 0.38A 5jj0A-3opeA:
14.4		 5jj0A-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.44A 5jj0B-3opeA:
17.7		 5jj0B-3opeA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.26A 5jj0B-3opeA:
17.7		 5jj0B-3opeA:
29.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.45A 5lsuA-3opeA:
26.6		 5lsuA-3opeA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
CYH A2268
CYH A2270
 None
SAM  A   7 (-3.4A)
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 1.44A 5lsuA-3opeA:
26.6		 5lsuA-3opeA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
ZN  A   1 (-2.7A)
 0.51A 5lsuB-3opeA:
26.0		 5lsuB-3opeA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		3 / 3 ASN A2217
TYR A2255
CYH A2268
 SAM  A   7 (-3.9A)
None
ZN  A   1 ( 2.5A)
 0.28A 5lsuB-3opeA:
26.0		 5lsuB-3opeA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.22A 5t0kA-3opeA:
17.6		 5t0kA-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.36A 5t0kA-3opeA:
17.6		 5t0kA-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
 1.31A 5t0kA-3opeA:
17.6		 5t0kA-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.40A 5t0kB-3opeA:
17.7		 5t0kB-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.22A 5t0kB-3opeA:
17.7		 5t0kB-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.05A 5t0mA-3opeA:
17.8		 5t0mA-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.39A 5t0mA-3opeA:
17.8		 5t0mA-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.19A 5t0mB-3opeA:
17.5		 5t0mB-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.40A 5t0mB-3opeA:
17.5		 5t0mB-3opeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 9 LYS A2150
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.50A 5tegA-3opeA:
14.5
5tegD-3opeA:
undetectable		 5tegA-3opeA:
22.87
5tegD-3opeA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 10 LYS A2150
GLY A2151
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.46A 5tegB-3opeA:
14.3
5tegE-3opeA:
undetectable		 5tegB-3opeA:
22.87
5tegE-3opeA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 10 GLY A2151
TYR A2194
ASN A2217
HIS A2218
TYR A2255
 SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
 0.35A 5tqrB-3opeA:
17.3		 5tqrB-3opeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 11 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.22A 5ttfA-3opeA:
17.5		 5ttfA-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 11 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.44A 5ttfA-3opeA:
17.5		 5ttfA-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.22A 5ttfB-3opeA:
17.6		 5ttfB-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.43A 5ttfB-3opeA:
17.6		 5ttfB-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
GLN A2266
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
SAM  A   7 (-2.9A)
 1.44A 5ttfC-3opeA:
17.5		 5ttfC-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.60A 5ttfC-3opeA:
17.5		 5ttfC-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.44A 5ttfC-3opeA:
17.5		 5ttfC-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.33A 5ttfD-3opeA:
14.6		 5ttfD-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 11 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.54A 5ttfD-3opeA:
14.6		 5ttfD-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.29A 5ttgA-3opeA:
14.8		 5ttgA-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.46A 5ttgA-3opeA:
14.8		 5ttgA-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.30A 5ttgB-3opeA:
14.5		 5ttgB-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 11 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.48A 5ttgB-3opeA:
14.5		 5ttgB-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.41A 5tuyA-3opeA:
17.7		 5tuyA-3opeA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.42A 5tuyA-3opeA:
17.7		 5tuyA-3opeA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.30A 5tuyB-3opeA:
14.5		 5tuyB-3opeA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.38A 5tuyB-3opeA:
14.5		 5tuyB-3opeA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.50A 5tuzA-3opeA:
14.8		 5tuzA-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.28A 5tuzB-3opeA:
14.7		 5tuzB-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.45A 5tuzB-3opeA:
14.7		 5tuzB-3opeA:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 ( 2.5A)
 1.39A 5updA-3opeA:
26.0		 5updA-3opeA:
40.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 11 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.49A 5updA-3opeA:
26.0		 5updA-3opeA:
40.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.48A 5updA-3opeA:
26.0		 5updA-3opeA:
40.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.05A 5updA-3opeA:
26.0		 5updA-3opeA:
40.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
 1.37A 5v21A-3opeA:
24.2		 5v21A-3opeA:
37.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.20A 5v21A-3opeA:
24.2		 5v21A-3opeA:
37.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		9 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
 0.48A 5v21A-3opeA:
24.2		 5v21A-3opeA:
37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.20A 5v9iA-3opeA:
17.4		 5v9iA-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.45A 5v9iA-3opeA:
17.4		 5v9iA-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.30A 5v9iB-3opeA:
17.5		 5v9iB-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 11 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.46A 5v9iB-3opeA:
17.5		 5v9iB-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 11 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.55A 5v9iC-3opeA:
17.4		 5v9iC-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 11 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.48A 5v9iC-3opeA:
17.4		 5v9iC-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.40A 5v9iD-3opeA:
17.6		 5v9iD-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
 0.60A 5v9iD-3opeA:
17.6		 5v9iD-3opeA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.26A 5v9jA-3opeA:
14.8		 5v9jA-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.45A 5v9jA-3opeA:
14.8		 5v9jA-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.30A 5v9jB-3opeA:
17.8		 5v9jB-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.49A 5v9jB-3opeA:
17.8		 5v9jB-3opeA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.19A 5vscA-3opeA:
17.7		 5vscA-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.43A 5vscA-3opeA:
17.7		 5vscA-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.17A 5vscB-3opeA:
14.4		 5vscB-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.44A 5vscB-3opeA:
14.4		 5vscB-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.48A 5vsdA-3opeA:
14.9		 5vsdA-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.28A 5vsdA-3opeA:
14.9		 5vsdA-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.30A 5vsdB-3opeA:
14.8		 5vsdB-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.48A 5vsdB-3opeA:
14.8		 5vsdB-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.20A 5vseA-3opeA:
17.7		 5vseA-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.41A 5vseA-3opeA:
17.7		 5vseA-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.18A 5vseB-3opeA:
17.2		 5vseB-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.43A 5vseB-3opeA:
17.2		 5vseB-3opeA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.49A 5vsfA-3opeA:
14.8		 5vsfA-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.29A 5vsfA-3opeA:
14.8		 5vsfA-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.28A 5vsfB-3opeA:
14.8		 5vsfB-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 0.45A 5vsfB-3opeA:
14.8		 5vsfB-3opeA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.48A 6a5kA-3opeA:
12.7		 6a5kA-3opeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.28A 6a5kA-3opeA:
12.7		 6a5kA-3opeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 None
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 1.08A 6a5kA-3opeA:
12.7		 6a5kA-3opeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
 1.31A 6a5mA-3opeA:
16.1		 6a5mA-3opeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 12 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.54A 6a5mA-3opeA:
16.1		 6a5mA-3opeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.37A 6a5mA-3opeA:
16.1		 6a5mA-3opeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 1.48A 6a5mA-3opeA:
16.1		 6a5mA-3opeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.00A 6a5mA-3opeA:
16.1		 6a5mA-3opeA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 11 GLY A2151
ASP A2192
TYR A2194
HIS A2218
TYR A2255
CYH A2268
CYH A2270
ILE A2279
 SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
None
 0.81A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2151
TRP A2152
ASN A2217
HIS A2218
CYH A2268
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
ZN  A   1 ( 2.5A)
 1.33A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 11 GLY A2151
TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
ILE A2279
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
None
 0.73A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 11 GLY A2151
TRP A2152
ASP A2192
HIS A2218
TYR A2255
CYH A2268
CYH A2270
ILE A2279
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
None
 0.76A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 (-2.7A)
 1.48A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 11 GLY A2151
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
ILE A2279
 SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
None
 0.83A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 11 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2268
CYH A2270
ILE A2279
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
None
 1.44A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 LYS A2150
GLY A2151
ASP A2192
TYR A2194
CYH A2270
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
SAM  A   7 (-3.4A)
ZN  A   1 (-2.7A)
 1.32A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 LYS A2150
GLY A2151
TRP A2152
ASN A2217
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
ZN  A   1 (-2.7A)
 1.27A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 LYS A2150
GLY A2151
TRP A2152
ASP A2192
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
ZN  A   1 (-2.7A)
 1.17A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 LYS A2150
GLY A2151
TYR A2194
ASN A2217
CYH A2270
 None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
ZN  A   1 (-2.7A)
 1.32A 6agoA-3opeA:
30.1		 6agoA-3opeA:
86.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
HIS A2218
TYR A2255
LYS A2269
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
None
None
ZN  A   1 (-2.7A)
 0.68A 6bp4A-3opeA:
17.7		 6bp4A-3opeA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 LYS A2150
TRP A2152
ARG A2214
HIS A2218
TYR A2255
CYH A2270
 None
None
None
None
None
ZN  A   1 (-2.7A)
 0.87A 6bp4A-3opeA:
17.7		 6bp4A-3opeA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.57A 6bp4B-3opeA:
18.7		 6bp4B-3opeA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		7 / 12 LYS A2150
GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.38A 6bp4B-3opeA:
18.7		 6bp4B-3opeA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2151
TRP A2152
HIS A2218
TYR A2255
CYH A2268
 SAM  A   7 (-3.4A)
None
None
None
ZN  A   1 ( 2.5A)
 1.42A 6cenA-3opeA:
25.8		 6cenA-3opeA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		8 / 11 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.49A 6cenA-3opeA:
25.8		 6cenA-3opeA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 GLY A2153
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.48A 6cenA-3opeA:
25.8		 6cenA-3opeA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 11 TRP A2152
ASN A2217
HIS A2218
TYR A2255
CYH A2270
 None
SAM  A   7 (-3.9A)
None
None
ZN  A   1 (-2.7A)
 1.06A 6cenA-3opeA:
25.8		 6cenA-3opeA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		5 / 12 TRP A2152
TYR A2194
PHE A2215
ASN A2217
HIS A2218
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
 0.51A 6chgC-3opeA:
10.7		 6chgC-3opeA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		6 / 12 LYS A2150
GLY A2151
TRP A2152
ASN A2217
HIS A2218
CYH A2268
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
None
ZN  A   1 ( 2.5A)
 1.37A 6ineA-3opeA:
28.9		 6ineA-3opeA:
84.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L
(Homo
sapiens) 		12 / 12 LYS A2150
GLY A2151
TRP A2152
ASP A2192
ASN A2217
HIS A2218
TYR A2255
GLN A2266
CYH A2268
LYS A2269
CYH A2270
ILE A2279
 None
SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.9A)
SAM  A   7 (-3.9A)
None
None
SAM  A   7 (-2.9A)
ZN  A   1 ( 2.5A)
None
ZN  A   1 (-2.7A)
None
 0.60A 6ineA-3opeA:
28.9		 6ineA-3opeA:
84.03