SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3opn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		6 / 12 GLY A  40
ASP A  62
GLY A  64
GLY A  69
ASP A 129
VAL A 130
 SO4  A   1 (-3.5A)
None
None
SO4  A   1 (-3.3A)
None
None
 0.82A 2oxtD-3opnA:
13.9		 2oxtD-3opnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		5 / 12 GLY A  40
GLY A  64
GLY A  69
ASN A 109
ASP A 129
 SO4  A   1 (-3.5A)
None
SO4  A   1 (-3.3A)
None
None
 0.80A 3eluA-3opnA:
13.4		 3eluA-3opnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		5 / 12 GLY A  40
GLY A  64
GLY A  69
ASN A 109
ASP A 129
 SO4  A   1 (-3.5A)
None
SO4  A   1 (-3.3A)
None
None
 0.87A 3elwA-3opnA:
13.7		 3elwA-3opnA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		5 / 12 GLY A  40
GLY A  64
GLY A  69
ASN A 109
ASP A 129
 SO4  A   1 (-3.5A)
None
SO4  A   1 (-3.3A)
None
None
 0.82A 3embA-3opnA:
13.6		 3embA-3opnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		5 / 12 SER A  38
GLY A  40
GLY A  64
GLY A  69
ASP A 129
 SO4  A   1 ( 2.5A)
SO4  A   1 (-3.5A)
None
SO4  A   1 (-3.3A)
None
 0.57A 3gczA-3opnA:
13.7		 3gczA-3opnA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		4 / 8 GLY A 150
ILE A 128
PHE A 108
PHE A 118
 None
 1.02A 3ko0B-3opnA:
undetectable
3ko0J-3opnA:
undetectable		 3ko0B-3opnA:
16.38
3ko0J-3opnA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		4 / 8 GLY A 150
ILE A 128
PHE A 108
PHE A 118
 None
 0.95A 3ko0K-3opnA:
undetectable
3ko0S-3opnA:
undetectable		 3ko0K-3opnA:
16.38
3ko0S-3opnA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		5 / 12 GLY A  64
GLY A  68
GLY A  69
ASP A  86
ASP A 129
 None
SO4  A   1 (-4.0A)
SO4  A   1 (-3.3A)
None
None
 0.81A 4b17A-3opnA:
17.3		 4b17A-3opnA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		5 / 12 SER A  38
GLY A  64
GLY A  68
GLY A  69
ASP A 129
 SO4  A   1 ( 2.5A)
None
SO4  A   1 (-4.0A)
SO4  A   1 (-3.3A)
None
 0.78A 4b17A-3opnA:
17.3		 4b17A-3opnA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		4 / 4 LYS A  95
ALA A  93
SER A  65
THR A  67
 None
None
None
SO4  A   1 (-4.2A)
 1.44A 4i89B-3opnA:
undetectable		 4i89B-3opnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		4 / 5 ILE A  96
PHE A 118
SER A  98
ASP A  86
 None
 1.36A 4rzvB-3opnA:
0.9		 4rzvB-3opnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3opn PUTATIVE HEMOLYSIN
(Lactococcus
lactis) 		5 / 12 SER A  38
GLY A  40
GLY A  64
GLY A  69
ASP A 129
 SO4  A   1 ( 2.5A)
SO4  A   1 (-3.5A)
None
SO4  A   1 (-3.3A)
None
 0.49A 5ekxA-3opnA:
13.3		 5ekxA-3opnA:
undetectable