SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3opw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 229
LEU A 176
LEU A 291
SER A 233
 None
 1.50A 1tz8D-3opwA:
undetectable		 1tz8D-3opwA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 199
LEU A 196
LYS A  55
 None
 1.48A 1yajK-3opwA:
undetectable		 1yajK-3opwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 164
VAL A 109
TRP A 228
 None
 1.26A 1zviA-3opwA:
undetectable		 1zviA-3opwA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 256
TYR A 328
TRP A 173
TRP A 228
 None
 1.24A 3cotA-3opwA:
undetectable		 3cotA-3opwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 256
TYR A 328
TRP A 173
TRP A 228
 None
 1.25A 3uzzA-3opwA:
0.0		 3uzzA-3opwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 256
TYR A 328
TRP A 173
TRP A 228
 None
 1.28A 3uzzB-3opwA:
undetectable		 3uzzB-3opwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_A_QMRA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 242
CYH A  31
TYR A 318
VAL A  46
ILE A 244
 None
 1.32A 4aftA-3opwA:
0.0
4aftB-3opwA:
0.0		 4aftA-3opwA:
20.11
4aftB-3opwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_C_QMRC301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 242
CYH A  31
TYR A 318
VAL A  46
ILE A 244
 None
 1.39A 4aftC-3opwA:
0.0
4aftD-3opwA:
0.0		 4aftC-3opwA:
20.11
4aftD-3opwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_E_QMRE301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A  46
ILE A 244
TYR A 242
CYH A  31
TYR A 318
 None
 1.36A 4aftA-3opwA:
0.0
4aftE-3opwA:
0.0		 4aftA-3opwA:
20.11
4aftE-3opwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 334
TYR A  60
LEU A  65
PHE A 249
 None
 0.93A 4twdF-3opwA:
undetectable
4twdJ-3opwA:
undetectable		 4twdF-3opwA:
22.69
4twdJ-3opwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 200
PHE A  27
TRP A  52
TYR A  21
 None
 1.34A 4v2yC-3opwA:
undetectable		 4v2yC-3opwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 242
CYH A  31
TYR A 318
VAL A  46
ILE A 244
 None
 1.42A 5ainB-3opwA:
0.0
5ainC-3opwA:
0.0		 5ainB-3opwA:
19.67
5ainC-3opwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_C_QMRC1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 242
CYH A  31
TYR A 318
VAL A  46
ILE A 244
 None
 1.39A 5ainC-3opwA:
0.0
5ainD-3opwA:
0.0		 5ainC-3opwA:
19.67
5ainD-3opwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_D_QMRD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 242
CYH A  31
TYR A 318
VAL A  46
ILE A 244
 None
 1.43A 5ainD-3opwA:
0.0
5ainE-3opwA:
0.0		 5ainD-3opwA:
19.67
5ainE-3opwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 200
PHE A  27
TRP A  52
TYR A  21
 None
 1.26A 5amkA-3opwA:
undetectable		 5amkA-3opwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 186
ASN A  89
GLN A  76
 None
 0.76A 5k7uA-3opwA:
undetectable		 5k7uA-3opwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 234
ILE A 258
GLU A 306
 None
 0.83A 6hcxA-3opwA:
undetectable		 6hcxA-3opwA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  43
GLN A 298
PRO A 259
ILE A 258
 None
 1.11A 6hzpA-3opwA:
undetectable		 6hzpA-3opwA:
21.92