SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3or2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.75A 1c9sI-3or2B:
undetectable
1c9sJ-3or2B:
undetectable		 1c9sI-3or2B:
11.35
1c9sJ-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.75A 1c9sU-3or2B:
undetectable
1c9sV-3or2B:
undetectable		 1c9sU-3or2B:
11.35
1c9sV-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT GAMA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		4 / 7 ASP C  14
GLY A  69
GLY A  68
TYR A  84
 SO3  A6573 ( 4.7A)
SO3  A6573 (-3.6A)
SO3  A6573 ( 4.3A)
None
 0.95A 1ekjE-3or2C:
undetectable
1ekjF-3or2C:
undetectable		 1ekjE-3or2C:
18.47
1ekjF-3or2C:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 4 ILE A 362
LEU A 391
VAL A 329
ILE A 327
 None
 0.74A 1fm6D-3or2A:
undetectable		 1fm6D-3or2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 7 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.72A 1gtnA-3or2B:
undetectable
1gtnK-3or2B:
undetectable		 1gtnA-3or2B:
11.35
1gtnK-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.76A 1gtnA-3or2B:
undetectable
1gtnB-3or2B:
undetectable		 1gtnA-3or2B:
11.35
1gtnB-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 7 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.79A 1gtnC-3or2B:
undetectable
1gtnD-3or2B:
undetectable		 1gtnC-3or2B:
11.35
1gtnD-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 6 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.78A 1gtnD-3or2B:
undetectable
1gtnE-3or2B:
undetectable		 1gtnD-3or2B:
11.35
1gtnE-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.74A 1gtnE-3or2B:
undetectable
1gtnF-3or2B:
undetectable		 1gtnE-3or2B:
11.35
1gtnF-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 7 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.73A 1gtnF-3or2B:
undetectable
1gtnG-3or2B:
undetectable		 1gtnF-3or2B:
11.35
1gtnG-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 7 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.76A 1gtnJ-3or2B:
undetectable
1gtnK-3or2B:
undetectable		 1gtnJ-3or2B:
11.35
1gtnK-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.72A 1gtnP-3or2B:
undetectable
1gtnQ-3or2B:
undetectable		 1gtnP-3or2B:
11.35
1gtnQ-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TYR A 201
VAL A 236
ILE A 327
GLU A 363
 None
 1.04A 1j96B-3or2A:
undetectable		 1j96B-3or2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3or2 SULFITE REDCUTASE
SUBUNIT GAMA
(Desulfovibrio
gigas) 		4 / 7 LEU C  77
ILE C  50
MET C  95
GLN C  47
 None
 1.26A 1kglA-3or2C:
undetectable		 1kglA-3or2C:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.38A 1lzxA-3or2A:
undetectable
1lzxB-3or2A:
undetectable		 1lzxA-3or2A:
21.83
1lzxB-3or2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.26A 1mmvA-3or2A:
undetectable
1mmvB-3or2A:
undetectable		 1mmvA-3or2A:
21.83
1mmvB-3or2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.27A 1p6hA-3or2A:
undetectable
1p6hB-3or2A:
undetectable		 1p6hA-3or2A:
21.83
1p6hB-3or2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT GAMA
(Desulfovibrio
gigas) 		3 / 3 GLU A 204
TRP A 366
LYS C  48
 None
 0.89A 1qu2A-3or2A:
undetectable		 1qu2A-3or2A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 8 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.28A 1rs6A-3or2A:
undetectable
1rs6B-3or2A:
undetectable		 1rs6A-3or2A:
21.83
1rs6B-3or2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.78A 1utdB-3or2B:
undetectable
1utdC-3or2B:
undetectable		 1utdB-3or2B:
11.35
1utdC-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.74A 1utdF-3or2B:
undetectable
1utdG-3or2B:
undetectable		 1utdF-3or2B:
11.35
1utdG-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.75A 1utdI-3or2B:
undetectable
1utdJ-3or2B:
undetectable		 1utdI-3or2B:
11.35
1utdJ-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 8 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.73A 1utdJ-3or2B:
undetectable
1utdK-3or2B:
undetectable		 1utdJ-3or2B:
11.35
1utdK-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 12 GLY A 143
ILE A 118
MET A 156
LEU A 102
VAL A 140
 None
 0.91A 1v2xA-3or2A:
undetectable		 1v2xA-3or2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT GAMA
(Desulfovibrio
gigas) 		4 / 7 PRO C  64
GLY C  87
LEU C  53
PRO C 101
 None
 0.91A 1ya4B-3or2C:
undetectable		 1ya4B-3or2C:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 6 LEU A 205
ASN A 170
LYS A 215
ASP A 233
 None
None
SRM  A 582 ( 2.7A)
None
 1.41A 2w98A-3or2A:
undetectable
2w98B-3or2A:
undetectable		 2w98A-3or2A:
20.80
2w98B-3or2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		3 / 3 CYH A  85
HIS A  64
PHE A  91
 None
 1.06A 3cr4X-3or2A:
undetectable		 3cr4X-3or2A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		5 / 12 ASN B 291
ALA A 235
ALA A 325
THR B  97
ILE B 289
 None
None
None
SRM  B 581 (-3.7A)
SRM  B 581 (-4.2A)
 1.24A 3dl9B-3or2B:
undetectable		 3dl9B-3or2B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		3 / 3 GLU B 220
SER B 250
VAL B 251
 None
 0.76A 3eeoA-3or2B:
undetectable		 3eeoA-3or2B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 4 LEU B 218
ALA B 227
VAL B 228
PRO B 225
 None
 1.24A 3gv1B-3or2B:
undetectable		 3gv1B-3or2B:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		3 / 3 GLU A 419
GLU A 418
TRP A 424
 None
 1.26A 3hrdA-3or2A:
undetectable
3hrdE-3or2A:
undetectable
3hrdF-3or2A:
undetectable		 3hrdA-3or2A:
22.44
3hrdE-3or2A:
22.44
3hrdF-3or2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TYR A 201
GLU A 367
TRP A 366
LEU A 171
 None
 1.21A 3k8mA-3or2A:
undetectable		 3k8mA-3or2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 12 GLY A 220
GLY A 238
PHE A 218
SER A 176
ALA A 186
 SF4  A 802 (-3.2A)
None
None
None
SF4  A 802 (-3.6A)
 1.14A 3kkzA-3or2A:
undetectable		 3kkzA-3or2A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.30A 3n5zA-3or2A:
undetectable
3n5zB-3or2A:
undetectable		 3n5zA-3or2A:
21.78
3n5zB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 6 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.37A 3n65A-3or2A:
undetectable
3n65B-3or2A:
undetectable		 3n65A-3or2A:
21.90
3n65B-3or2A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 5 GLU A 377
LEU A 379
GLN A 340
GLY A 330
 None
 1.26A 3pp1A-3or2A:
2.4		 3pp1A-3or2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 5 GLY A 320
ASP A 242
ARG A 305
MET A 193
 None
 1.26A 3qx3A-3or2A:
undetectable		 3qx3A-3or2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 5 GLY A 320
ASP A 242
ARG A 305
MET A 193
 None
 1.32A 3qx3B-3or2A:
undetectable		 3qx3B-3or2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 12 GLY A 220
GLY A 238
PHE A 218
SER A 176
ALA A 186
 SF4  A 802 (-3.2A)
None
None
None
SF4  A 802 (-3.6A)
 1.29A 3t7sA-3or2A:
undetectable		 3t7sA-3or2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 12 GLY A 220
GLY A 238
PHE A 218
SER A 176
ALA A 186
 SF4  A 802 (-3.2A)
None
None
None
SF4  A 802 (-3.6A)
 1.24A 3t7sB-3or2A:
undetectable		 3t7sB-3or2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 12 GLY A 220
GLY A 238
PHE A 218
SER A 176
ALA A 186
 SF4  A 802 (-3.2A)
None
None
None
SF4  A 802 (-3.6A)
 1.30A 3t7sD-3or2A:
undetectable		 3t7sD-3or2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		5 / 9 GLY B 286
GLY B 345
ILE B 344
LEU B 355
VAL B 302
 None
 0.92A 3u7sB-3or2B:
undetectable		 3u7sB-3or2B:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 9 ALA A 103
LEU A 141
LEU A 160
ASN A 161
ILE A 152
 None
 1.09A 3wdmC-3or2A:
undetectable		 3wdmC-3or2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.31A 4ctpA-3or2A:
undetectable
4ctpB-3or2A:
undetectable		 4ctpA-3or2A:
21.78
4ctpB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.24A 4ctqA-3or2A:
undetectable
4ctqB-3or2A:
undetectable		 4ctqA-3or2A:
21.78
4ctqB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 5 PHE B 305
ILE B 206
GLY B 205
THR B 156
 None
 0.97A 4ejjC-3or2B:
undetectable		 4ejjC-3or2B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		3 / 3 PHE B 365
VAL B 204
ILE B 206
 None
 0.55A 4emaA-3or2B:
undetectable		 4emaA-3or2B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 11 HIS A  98
ILE A  81
GLY A 165
GLY A 166
ASN A 170
 None
SRM  A 582 ( 4.3A)
None
None
None
 1.22A 4fglA-3or2A:
2.2
4fglB-3or2A:
2.1		 4fglA-3or2A:
21.58
4fglB-3or2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 8 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 801 (-2.4A)
SF4  A 801 ( 4.1A)
None
 0.74A 4fo4A-3or2A:
undetectable		 4fo4A-3or2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 8 ASN A 300
CYH A 284
THR A 286
MET A 307
 None
SF4  A 801 (-2.4A)
SF4  A 801 ( 4.1A)
None
 0.75A 4fo4B-3or2A:
undetectable		 4fo4B-3or2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 12 SER A 169
TYR A 212
ALA A 333
ASP A 233
GLY A 168
 None
SRM  A 582 (-4.6A)
SRM  A 582 (-3.4A)
None
None
 1.19A 4iilA-3or2A:
undetectable		 4iilA-3or2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.31A 4jsfA-3or2A:
undetectable
4jsfB-3or2A:
undetectable		 4jsfA-3or2A:
21.78
4jsfB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.32A 4jsgA-3or2A:
undetectable
4jsgB-3or2A:
undetectable		 4jsgA-3or2A:
21.78
4jsgB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 4 PHE A  91
HIS A  64
GLY A  52
ILE A  53
 None
 1.40A 4k50E-3or2A:
undetectable		 4k50E-3or2A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 4 PHE A  91
HIS A  64
GLY A  52
ILE A  53
 None
 1.41A 4k50M-3or2A:
undetectable		 4k50M-3or2A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		5 / 12 GLY B 160
PRO B 161
LEU A   9
ILE A  24
LEU A  50
 None
 0.95A 4n49A-3or2B:
undetectable		 4n49A-3or2B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		5 / 12 ASP A 163
THR A 198
GLN A 202
LEU A 205
THR A 173
 None
 1.12A 4ng6A-3or2A:
undetectable		 4ng6A-3or2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 4 SER B 290
ASP B 339
ASP B 330
ASP B 200
 SRM  B 581 (-2.5A)
None
None
None
 1.45A 4uciA-3or2B:
0.2		 4uciA-3or2B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 4 SER B 290
ASP B 339
ASP B 330
ASP B 200
 SRM  B 581 (-2.5A)
None
None
None
 1.46A 4uciB-3or2B:
0.0		 4uciB-3or2B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.21A 4uh0A-3or2A:
undetectable
4uh0B-3or2A:
undetectable		 4uh0A-3or2A:
21.78
4uh0B-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.33A 4uh6A-3or2A:
undetectable
4uh6B-3or2A:
undetectable		 4uh6A-3or2A:
20.67
4uh6B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.32A 4uh6A-3or2A:
undetectable
4uh6B-3or2A:
undetectable		 4uh6A-3or2A:
20.67
4uh6B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 6 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.26A 4v3wA-3or2A:
undetectable
4v3wB-3or2A:
undetectable		 4v3wA-3or2A:
21.78
4v3wB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.23A 5ad5A-3or2A:
undetectable
5ad5B-3or2A:
undetectable		 5ad5A-3or2A:
21.78
5ad5B-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.30A 5ad6A-3or2A:
undetectable
5ad6B-3or2A:
undetectable		 5ad6A-3or2A:
21.78
5ad6B-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.19A 5ad6A-3or2A:
undetectable
5ad6B-3or2A:
undetectable		 5ad6A-3or2A:
21.78
5ad6B-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.23A 5adaA-3or2A:
undetectable
5adaB-3or2A:
undetectable		 5adaA-3or2A:
21.78
5adaB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.29A 5adgA-3or2A:
undetectable
5adgB-3or2A:
undetectable		 5adgA-3or2A:
20.67
5adgB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.30A 5adgA-3or2A:
undetectable
5adgB-3or2A:
undetectable		 5adgA-3or2A:
20.67
5adgB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.23A 5adiA-3or2A:
undetectable
5adiB-3or2A:
undetectable		 5adiA-3or2A:
20.67
5adiB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 8 SER A 167
GLY A  78
ILE A 152
GLY A  72
 None
 0.64A 5alcL-3or2A:
undetectable		 5alcL-3or2A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 5 GLU B 109
THR B 110
HIS B  44
LEU B  47
 None
None
SRM  B 581 (-3.8A)
None
 0.98A 5axaA-3or2B:
undetectable		 5axaA-3or2B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 5 GLU B 109
THR B 110
HIS B  44
LEU B  47
 None
None
SRM  B 581 (-3.8A)
None
 0.99A 5axaC-3or2B:
undetectable		 5axaC-3or2B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		4 / 6 SER B 140
GLY B 338
ASP B 339
GLY B 287
 SRM  B 581 (-2.7A)
None
None
None
 0.94A 5cdnC-3or2B:
2.8
5cdnD-3or2B:
undetectable		 5cdnC-3or2B:
19.77
5cdnD-3or2B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.29A 5fvtA-3or2A:
undetectable
5fvtB-3or2A:
undetectable		 5fvtA-3or2A:
21.78
5fvtB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.32A 5fvwA-3or2A:
undetectable
5fvwB-3or2A:
undetectable		 5fvwA-3or2A:
20.67
5fvwB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.39A 5fvwA-3or2A:
undetectable
5fvwB-3or2A:
undetectable		 5fvwA-3or2A:
20.67
5fvwB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.33A 5fvxA-3or2A:
undetectable
5fvxB-3or2A:
undetectable		 5fvxA-3or2A:
20.67
5fvxB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.23A 5fw0A-3or2A:
undetectable
5fw0B-3or2A:
undetectable		 5fw0A-3or2A:
21.78
5fw0B-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.27A 5g0nA-3or2A:
undetectable
5g0nB-3or2A:
undetectable		 5g0nA-3or2A:
21.90
5g0nB-3or2A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		3 / 3 ARG A 207
THR B  19
ASP B  20
 None
 0.92A 5g5gA-3or2A:
undetectable
5g5gB-3or2A:
undetectable		 5g5gA-3or2A:
19.68
5g5gB-3or2A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		5 / 12 ILE B 206
VAL B 301
ILE B 142
ILE B 319
VAL B 165
 None
 0.99A 5mueA-3or2B:
undetectable		 5mueA-3or2B:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		3 / 3 HIS A 133
ASN B  99
ALA B  69
 None
 0.61A 5n4tB-3or2A:
undetectable		 5n4tB-3or2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 6 THR A 162
ASP A 163
LEU A 102
ASP A 138
 None
None
None
SRM  A 582 (-3.8A)
 0.94A 5tdzA-3or2A:
undetectable		 5tdzA-3or2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.23A 5unsA-3or2A:
undetectable
5unsB-3or2A:
undetectable		 5unsA-3or2A:
21.78
5unsB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.22A 5untA-3or2A:
undetectable
5untB-3or2A:
undetectable		 5untA-3or2A:
21.78
5untB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.19A 5unuA-3or2A:
undetectable
5unuB-3or2A:
undetectable		 5unuA-3or2A:
21.78
5unuB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.29A 5uo1A-3or2A:
undetectable
5uo1B-3or2A:
undetectable		 5uo1A-3or2A:
20.67
5uo1B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.28A 5uo1A-3or2A:
undetectable
5uo1B-3or2A:
undetectable		 5uo1A-3or2A:
20.67
5uo1B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.29A 5uo2A-3or2A:
undetectable
5uo2B-3or2A:
undetectable		 5uo2A-3or2A:
20.67
5uo2B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.34A 5uo2A-3or2A:
undetectable
5uo2B-3or2A:
undetectable		 5uo2A-3or2A:
20.67
5uo2B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.24A 5uo3A-3or2A:
undetectable
5uo3B-3or2A:
undetectable		 5uo3A-3or2A:
20.67
5uo3B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.34A 5uo4A-3or2A:
undetectable
5uo4B-3or2A:
undetectable		 5uo4A-3or2A:
20.67
5uo4B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.34A 5uo4A-3or2A:
undetectable
5uo4B-3or2A:
undetectable		 5uo4A-3or2A:
20.67
5uo4B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.29A 5uo5A-3or2A:
undetectable
5uo5B-3or2A:
undetectable		 5uo5A-3or2A:
20.67
5uo5B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.35A 5uo5A-3or2A:
undetectable
5uo5B-3or2A:
undetectable		 5uo5A-3or2A:
20.67
5uo5B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.34A 5uo6A-3or2A:
undetectable
5uo6B-3or2A:
undetectable		 5uo6A-3or2A:
20.67
5uo6B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 8 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.29A 5uo7A-3or2A:
undetectable
5uo7B-3or2A:
undetectable		 5uo7A-3or2A:
20.67
5uo7B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.33A 5uo7A-3or2A:
undetectable
5uo7B-3or2A:
undetectable		 5uo7A-3or2A:
20.67
5uo7B-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3or2 SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas) 		5 / 12 ARG B 336
GLY B 338
GLY B 202
SER B 199
ILE B 201
 SRM  B 581 (-3.0A)
None
None
None
None
 1.17A 5vooA-3or2B:
undetectable		 5vooA-3or2B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.24A 5vuiA-3or2A:
undetectable
5vuiB-3or2A:
undetectable		 5vuiA-3or2A:
21.78
5vuiB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.21A 5vuiA-3or2A:
undetectable
5vuiB-3or2A:
undetectable		 5vuiA-3or2A:
21.78
5vuiB-3or2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.36A 5vuvA-3or2A:
undetectable
5vuvB-3or2A:
undetectable		 5vuvA-3or2A:
20.67
5vuvB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.29A 5vuvA-3or2A:
undetectable
5vuvB-3or2A:
undetectable		 5vuvA-3or2A:
20.67
5vuvB-3or2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 5 GLY A 320
ASP A 242
ARG A 305
MET A 193
 None
 1.28A 5zrfB-3or2A:
2.8		 5zrfB-3or2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 4 GLY A 320
ASP A 242
ARG A 305
MET A 193
 None
 1.30A 5zrfA-3or2A:
2.9		 5zrfA-3or2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT GAMA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		5 / 7 GLY A  78
GLY A  77
GLY C  87
GLY C  91
GLY C  89
 None
 0.97A 6ag0A-3or2A:
undetectable		 6ag0A-3or2A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.31A 6aurA-3or2A:
undetectable
6aurB-3or2A:
undetectable		 6aurA-3or2A:
11.08
6aurB-3or2A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.30A 6aurA-3or2A:
undetectable
6aurB-3or2A:
undetectable		 6aurA-3or2A:
11.08
6aurB-3or2A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.26A 6autA-3or2A:
undetectable
6autB-3or2A:
undetectable		 6autA-3or2A:
11.08
6autB-3or2A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.26A 6autA-3or2A:
undetectable
6autB-3or2A:
undetectable		 6autA-3or2A:
11.08
6autB-3or2A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.25A 6auuA-3or2A:
undetectable
6auuB-3or2A:
undetectable		 6auuA-3or2A:
11.08
6auuB-3or2A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.36A 6auyA-3or2A:
undetectable
6auyB-3or2A:
undetectable		 6auyA-3or2A:
11.78
6auyB-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.33A 6auzA-3or2A:
undetectable
6auzB-3or2A:
undetectable		 6auzA-3or2A:
11.78
6auzB-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.36A 6auzA-3or2A:
undetectable
6auzB-3or2A:
undetectable		 6auzA-3or2A:
11.78
6auzB-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.35A 6av0A-3or2A:
undetectable
6av0B-3or2A:
undetectable		 6av0A-3or2A:
11.78
6av0B-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.36A 6av1A-3or2A:
undetectable
6av1B-3or2A:
undetectable		 6av1A-3or2A:
11.78
6av1B-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.37A 6av3A-3or2A:
undetectable
6av3B-3or2A:
undetectable		 6av3A-3or2A:
11.78
6av3B-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.37A 6av4A-3or2A:
undetectable
6av4B-3or2A:
undetectable		 6av4A-3or2A:
11.78
6av4B-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.36A 6av5A-3or2A:
undetectable
6av5B-3or2A:
undetectable		 6av5A-3or2A:
11.78
6av5B-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.35A 6av5A-3or2A:
undetectable
6av5B-3or2A:
undetectable		 6av5A-3or2A:
11.78
6av5B-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
SULFITE REDCUTASE
SUBUNIT BETA
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		5 / 12 HIS B 152
GLY B 147
ALA B 158
ILE B 190
PRO A 334
 SRM  A 582 (-4.4A)
None
None
None
None
 1.09A 6b3aA-3or2B:
undetectable		 6b3aA-3or2B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.26A 6cicA-3or2A:
undetectable
6cicB-3or2A:
undetectable		 6cicA-3or2A:
11.78
6cicB-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.31A 6cicA-3or2A:
undetectable
6cicB-3or2A:
undetectable		 6cicA-3or2A:
11.78
6cicB-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 MET A 370
TRP A 369
TRP A 368
GLU A 371
 None
 1.20A 6cidA-3or2A:
undetectable
6cidB-3or2A:
undetectable		 6cidA-3or2A:
11.78
6cidB-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 TRP A 368
GLU A 371
MET A 370
TRP A 369
 None
 1.28A 6cidA-3or2A:
undetectable
6cidB-3or2A:
undetectable		 6cidA-3or2A:
11.78
6cidB-3or2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3or2 SULFITE REDCUTASE
SUBUNIT ALPHA
(Desulfovibrio
gigas) 		4 / 7 ASP A 138
GLN A 104
LYS A 108
LYS A 217
 SRM  A 582 (-3.8A)
None
None
SRM  A 582 (-2.7A)
 1.50A 6g31A-3or2A:
2.4		 6g31A-3or2A:
12.09