SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3orf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 7 THR A 132
SER A 133
SER A 126
LEU A 169
 None
 1.16A 1ibgL-3orfA:
undetectable		 1ibgL-3orfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 8 LEU A 193
VAL A 196
VAL A   7
VAL A  72
 None
 0.84A 1iwiA-3orfA:
undetectable		 1iwiA-3orfA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A 167
ASN A 213
LEU A 119
ILE A 168
LEU A 200
 None
 1.32A 1lhuA-3orfA:
undetectable		 1lhuA-3orfA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 8 LEU A 193
VAL A 196
VAL A   7
VAL A  72
 None
 0.82A 1t86A-3orfA:
undetectable		 1t86A-3orfA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 6 LEU A 193
VAL A 196
VAL A   7
VAL A  72
 None
 0.98A 2z97A-3orfA:
undetectable		 2z97A-3orfA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 8 SER A  24
PHE A  22
VAL A 196
LEU A  14
 None
None
None
NAD  A 901 (-4.6A)
 1.05A 3jq7C-3orfA:
20.8		 3jq7C-3orfA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 6 PHE A  88
ILE A 136
ALA A 137
THR A 141
 None
 0.93A 3mdrA-3orfA:
undetectable		 3mdrA-3orfA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 6 PHE A  88
ILE A 136
ALA A 137
THR A 141
 None
 0.84A 3mdrB-3orfA:
undetectable		 3mdrB-3orfA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 8 LEU A 173
ALA A  16
GLY A 124
PRO A 170
 NAD  A 901 (-3.9A)
None
None
NAD  A 901 (-3.9A)
 0.94A 3ny4A-3orfA:
undetectable		 3ny4A-3orfA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 VAL A 121
VAL A  18
LEU A 200
GLY A   9
ALA A  74
 None
None
None
NAD  A 901 ( 3.7A)
NAD  A 901 (-4.9A)
 1.26A 3pghA-3orfA:
undetectable		 3pghA-3orfA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 ASN A  37
ALA A  40
ASP A  41
VAL A   7
ILE A   5
 None
 1.06A 3spkB-3orfA:
undetectable		 3spkB-3orfA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.09A 3uboB-3orfA:
5.8		 3uboB-3orfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.09A 4e3aA-3orfA:
5.9		 4e3aA-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 LEU A 169
VAL A 217
ALA A  75
LEU A 119
VAL A 196
 None
None
NAD  A 901 (-3.4A)
None
None
 1.29A 4ib4A-3orfA:
undetectable		 4ib4A-3orfA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.09A 4k93A-3orfA:
6.2		 4k93A-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.08A 4k9cA-3orfA:
5.7		 4k9cA-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.10A 4kadA-3orfA:
6.5		 4kadA-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.09A 4kadB-3orfA:
6.2		 4kadB-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 8 LEU A 193
VAL A 196
VAL A   7
VAL A  72
 None
 0.87A 4l4bA-3orfA:
undetectable		 4l4bA-3orfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.09A 4lbxB-3orfA:
5.9		 4lbxB-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.08A 4lc4A-3orfA:
6.1		 4lc4A-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  76
GLY A  77
ASN A  99
THR A 175
THR A 123
 NAD  A 901 (-3.6A)
NAD  A 901 (-4.3A)
NAD  A 901 (-4.0A)
NAD  A 901 (-3.2A)
NAD  A 901 ( 4.1A)
 1.09A 4lc4B-3orfA:
5.8		 4lc4B-3orfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 12 LEU A 169
VAL A 217
ALA A  75
LEU A 119
VAL A 196
 None
None
NAD  A 901 (-3.4A)
None
None
 1.33A 4nc3A-3orfA:
undetectable		 4nc3A-3orfA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		3 / 3 PHE A 219
THR A  70
LEU A  14
 None
None
NAD  A 901 (-4.6A)
 0.66A 4qztA-3orfA:
undetectable		 4qztA-3orfA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 6 GLY A 214
GLY A 167
SER A 204
ARG A 210
 None
 0.99A 4z53A-3orfA:
undetectable
4z53B-3orfA:
undetectable		 4z53A-3orfA:
17.28
4z53B-3orfA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		4 / 8 LEU A 193
VAL A 196
VAL A   7
VAL A  72
 None
 0.86A 6cp4A-3orfA:
undetectable		 6cp4A-3orfA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3orf DIHYDROPTERIDINE
REDUCTASE
(Dictyostelium
discoideum) 		5 / 10 GLY A  81
SER A  91
GLU A  87
ASP A  86
ILE A 136
 None
 1.20A 6exiA-3orfA:
7.0		 6exiA-3orfA:
15.56