SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3org'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 6 VAL A 250
GLY A 251
ALA A 106
LEU A 102
 None
 0.75A 1e7bB-3orgA:
2.5		 1e7bB-3orgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3org CMCLC
(Cyanidioschyzon
merolae) 		3 / 3 ALA A 246
VAL A 283
TRP A 280
 None
 0.95A 1grmA-3orgA:
undetectable		 1grmA-3orgA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 3org CMCLC
(Cyanidioschyzon
merolae) 		3 / 3 ALA A 246
VAL A 283
TRP A 280
 None
 0.95A 1grmB-3orgA:
undetectable		 1grmB-3orgA:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 6 GLY A 261
GLY A 488
PHE A 434
PHE A 430
 None
 1.03A 2qx6A-3orgA:
undetectable
2qx6B-3orgA:
undetectable		 2qx6A-3orgA:
16.30
2qx6B-3orgA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 PHE A 430
GLY A 428
GLY A 166
LEU A 167
VAL A 214
 None
 0.82A 3av6A-3orgA:
undetectable		 3av6A-3orgA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 ALA A 286
GLY A 103
LEU A 287
SER A 254
GLY A 251
 None
 1.06A 3g2oA-3orgA:
undetectable		 3g2oA-3orgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 ALA A 286
GLY A 282
LEU A 102
LEU A 287
GLY A 251
 None
 1.00A 3g2oA-3orgA:
undetectable		 3g2oA-3orgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 ALA A 286
GLY A 282
LEU A 102
LEU A 287
GLY A 251
 None
 0.96A 3g2oB-3orgA:
undetectable		 3g2oB-3orgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 11 ILE A 421
ILE A 436
ILE A 338
VAL A 341
GLY A 334
 None
 0.90A 3kw4A-3orgA:
undetectable		 3kw4A-3orgA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 5 ARG A 531
LEU A 530
VAL A 672
ASP A 533
 None
 1.06A 3ufnA-3orgA:
undetectable
3ufnB-3orgA:
undetectable		 3ufnA-3orgA:
9.81
3ufnB-3orgA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 7 PHE A 434
GLY A 437
THR A 385
PHE A 390
 None
 1.16A 3vnsA-3orgA:
undetectable		 3vnsA-3orgA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 VAL A 519
PRO A 168
GLU A 210
SER A 433
GLY A 208
 None
None
None
None
CL  A 802 (-3.6A)
 1.42A 4hvcA-3orgA:
undetectable		 4hvcA-3orgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 7 ILE A 436
LEU A 333
GLY A 334
PHE A 337
 None
 0.88A 4iqqA-3orgA:
undetectable		 4iqqA-3orgA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 8 ILE A 436
LEU A 333
GLY A 334
PHE A 337
 None
 0.77A 4iqqD-3orgA:
undetectable		 4iqqD-3orgA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 102
LEU A 264
GLY A 251
ALA A 217
LEU A 174
 None
 1.21A 4retA-3orgA:
undetectable		 4retA-3orgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 102
LEU A 264
GLY A 251
ALA A 217
LEU A 174
 None
 1.21A 4retC-3orgA:
undetectable		 4retC-3orgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 9 ALA A 249
SER A 266
ALA A 247
ALA A 217
ALA A 253
 None
 1.23A 4twdA-3orgA:
2.0
4twdB-3orgA:
2.0
4twdC-3orgA:
2.0
4twdD-3orgA:
1.5
4twdE-3orgA:
1.9		 4twdA-3orgA:
18.34
4twdB-3orgA:
18.34
4twdC-3orgA:
18.34
4twdD-3orgA:
18.34
4twdE-3orgA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 ALA A 290
LEU A 287
GLY A 257
SER A 254
ALA A 253
 None
 1.18A 4ypmA-3orgA:
undetectable		 4ypmA-3orgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 ILE A 698
TYR A 688
HIS A 552
PHE A 575
VAL A 577
 None
 1.17A 5n0xB-3orgA:
undetectable		 5n0xB-3orgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 6 ARG A 701
GLY A 707
PRO A 525
GLU A 702
 None
 0.93A 5ny7A-3orgA:
undetectable		 5ny7A-3orgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3org CMCLC
(Cyanidioschyzon
merolae) 		5 / 12 VAL A 519
PRO A 168
GLU A 210
SER A 433
GLY A 208
 None
None
None
None
CL  A 802 (-3.6A)
 1.50A 5xioA-3orgA:
undetectable		 5xioA-3orgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3org CMCLC
(Cyanidioschyzon
merolae) 		3 / 3 ARG A 491
HIS A 492
ARG A 317
 None
 1.12A 6dwdD-3orgA:
undetectable		 6dwdD-3orgA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3org CMCLC
(Cyanidioschyzon
merolae) 		4 / 6 ALA A 503
GLY A 437
ILE A 483
PHE A 484
 None
 0.70A 6f8cA-3orgA:
2.5		 6f8cA-3orgA:
10.24