SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3orh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 132
ALA A  57
GLN A 148
ILE A 207
LEU A 197
 None
 1.19A 1dhfB-3orhA:
3.1		 1dhfB-3orhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 11 PRO A 125
LEU A 159
GLY A 164
TRP A  87
LEU A  65
 None
 1.18A 1lwcA-3orhA:
undetectable		 1lwcA-3orhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A  68
GLU A  90
ASP A 135
 SAH  A4000 (-3.4A)
SAH  A4000 (-2.7A)
SAH  A4000 (-3.7A)
 0.39A 2b25B-3orhA:
12.0		 2b25B-3orhA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 GLY A 163
GLY A 164
PHE A 157
PHE A 202
 None
 1.05A 2qr2A-3orhA:
undetectable
2qr2B-3orhA:
undetectable		 2qr2A-3orhA:
22.44
2qr2B-3orhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 132
ALA A  57
GLN A 148
ILE A 207
LEU A 197
 None
 1.10A 2w3mA-3orhA:
undetectable		 2w3mA-3orhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A  68
ILE A  89
GLU A  90
ASP A 135
 SAH  A4000 (-3.4A)
None
SAH  A4000 (-2.7A)
SAH  A4000 (-3.7A)
 0.35A 3a7eA-3orhA:
13.3		 3a7eA-3orhA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A  70
GLU A  90
ASP A 135
GLU A 118
 SAH  A4000 (-3.3A)
SAH  A4000 (-2.7A)
SAH  A4000 (-3.7A)
SAH  A4000 (-3.2A)
 0.70A 3vywC-3orhA:
12.4		 3vywC-3orhA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 132
ALA A  57
GLN A 148
ILE A 207
LEU A 197
 None
 1.12A 4kebB-3orhA:
undetectable		 4kebB-3orhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 GLY A  68
GLY A  70
GLU A  90
ASP A 135
 SAH  A4000 (-3.4A)
SAH  A4000 (-3.3A)
SAH  A4000 (-2.7A)
SAH  A4000 (-3.7A)
 0.56A 5ergB-3orhA:
12.6		 5ergB-3orhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ARG A 100
LEU A  99
ALA A  75
GLN A  97
 None
 0.96A 6b89B-3orhA:
undetectable		 6b89B-3orhA:
15.58