SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3orj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 SER A 201
GLU A 202
GLU A 203
 None
 0.55A 1eqbD-3orjA:
undetectable		 1eqbD-3orjA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 SER A 201
GLU A 202
GLU A 203
 None
 0.55A 1eqbB-3orjA:
undetectable		 1eqbB-3orjA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		5 / 12 PHE A 364
GLN A 317
VAL A 372
TYR A 350
ILE A 421
 None
 1.20A 1fkbA-3orjA:
undetectable		 1fkbA-3orjA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		4 / 4 ILE A  69
LEU A  79
VAL A  82
ILE A 122
 None
 0.90A 1fm6D-3orjA:
undetectable		 1fm6D-3orjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQE_A_QUNA500_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		5 / 12 VAL A 289
VAL A 353
TRP A 345
ASP A 348
CYH A 349
 None
 1.43A 1jqeA-3orjA:
0.0		 1jqeA-3orjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 ALA A 400
VAL A 395
TRP A 389
 None
 0.89A 1kqeA-3orjA:
undetectable
1kqeE-3orjA:
undetectable		 1kqeA-3orjA:
3.12
1kqeE-3orjA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 ALA A 400
VAL A 395
TRP A 389
 None
 0.89A 1kqeB-3orjA:
undetectable
1kqeD-3orjA:
undetectable		 1kqeB-3orjA:
3.12
1kqeD-3orjA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 TRP A 389
ALA A 400
VAL A 395
 None
 0.89A 1kqeB-3orjA:
undetectable
1kqeD-3orjA:
undetectable		 1kqeB-3orjA:
3.12
1kqeD-3orjA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_1
(SERINE/THREONINE
PHOSPHATASE B2
FK506-BINDING
PROTEIN)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		4 / 4 TRP A 355
SER A 329
PHE A 331
GLU A 412
 None
 1.32A 1tcoA-3orjA:
0.0		 1tcoA-3orjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		4 / 8 ALA A 397
GLY A 336
SER A 401
ALA A 402
 None
 0.71A 2vh3B-3orjA:
undetectable		 2vh3B-3orjA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 TYR A  87
GLU A 113
ASP A 186
 None
 0.86A 3bxoA-3orjA:
undetectable		 3bxoA-3orjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 354
ILE A 320
ILE A 441
VAL A 372
 None
 0.75A 3p4wC-3orjA:
undetectable		 3p4wC-3orjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 PHE A 331
VAL A 372
ILE A 320
 None
 0.63A 4emaA-3orjA:
undetectable		 4emaA-3orjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		4 / 7 PHE A 364
TYR A 352
GLN A 370
PHE A 318
 None
 1.44A 4grqA-3orjA:
undetectable
4grqC-3orjA:
undetectable		 4grqA-3orjA:
15.15
4grqC-3orjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		4 / 7 TYR A 131
GLY A  73
TYR A 133
GLY A  45
 None
EDO  A 470 (-4.2A)
None
None
 0.90A 4rdxA-3orjA:
undetectable		 4rdxA-3orjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		5 / 11 ALA A 216
VAL A 209
GLY A 189
SER A 212
GLY A 214
 None
 1.22A 4xnxA-3orjA:
undetectable		 4xnxA-3orjA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 5 GLY A 259
GLY A 261
GLU A 156
 None
 0.50A 4z2eA-3orjA:
undetectable
4z2eD-3orjA:
undetectable		 4z2eA-3orjA:
22.03
4z2eD-3orjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		4 / 6 TRP A 355
SER A 329
PHE A 331
GLU A 412
 None
 1.24A 5b8iA-3orjA:
undetectable		 5b8iA-3orjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		5 / 9 VAL A 279
LEU A 332
LEU A 271
GLN A 276
VAL A 439
 None
 1.30A 6czmA-3orjA:
undetectable
6czmB-3orjA:
undetectable		 6czmA-3orjA:
21.33
6czmB-3orjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3orj SUGAR-BINDING
PROTEIN
(Bacteroides
ovatus) 		3 / 3 TRP A 355
ILE A 416
GLU A 412
 None
 0.84A 6hcxA-3orjA:
undetectable		 6hcxA-3orjA:
10.53