SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3orq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 5 PRO A  96
GLY A 199
ASN A 200
GLY A 297
 None
 0.75A 1zlqA-3orqA:
undetectable		 1zlqA-3orqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLU A 254
PHE A 256
LEU A 316
GLN A 159
ARG A 108
 MG  A 375 ( 2.4A)
ADP  A 376 (-4.5A)
None
ADP  A 376 (-3.6A)
ADP  A 376 (-3.2A)
 1.18A 2e7fB-3orqA:
undetectable		 2e7fB-3orqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 GLY A  18
ASP A  39
SER A  41
 None
 0.67A 3brfA-3orqA:
undetectable		 3brfA-3orqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 ILE A 337
SER A 341
LYS A 340
GLY A 339
LEU A 320
 None
None
POP  A 377 (-2.9A)
None
None
 1.13A 3ik6B-3orqA:
undetectable
3ik6E-3orqA:
undetectable		 3ik6B-3orqA:
21.17
3ik6E-3orqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A 320
ILE A 337
SER A 341
LYS A 340
GLY A 339
 None
None
None
POP  A 377 (-2.9A)
None
 1.18A 3ik6B-3orqA:
undetectable
3ik6E-3orqA:
undetectable		 3ik6B-3orqA:
21.17
3ik6E-3orqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ILE A 337
SER A 341
LYS A 340
GLY A 339
LEU A 320
 None
None
POP  A 377 (-2.9A)
None
None
 1.19A 3iluB-3orqA:
undetectable
3iluE-3orqA:
undetectable		 3iluB-3orqA:
21.17
3iluE-3orqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 GLU A 254
PHE A 256
LEU A 316
GLN A 159
ARG A 108
 MG  A 375 ( 2.4A)
ADP  A 376 (-4.5A)
None
ADP  A 376 (-3.6A)
ADP  A 376 (-3.2A)
 1.17A 4djfB-3orqA:
undetectable		 4djfB-3orqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 GLY A  17
GLY A  16
TYR A  58
ASN A  80
 None
 0.62A 4fgkB-3orqA:
3.3		 4fgkB-3orqA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ALA A 101
GLN A 103
LEU A  86
ALA A  83
VAL A 295
 None
 1.07A 4nqaA-3orqA:
undetectable		 4nqaA-3orqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 6 ILE A  15
ILE A 292
ILE A  95
LEU A  67
 None
 0.76A 4o8fB-3orqA:
undetectable		 4o8fB-3orqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 TYR A 278
THR A 353
THR A 222
 None
 0.82A 5aoxE-3orqA:
undetectable		 5aoxE-3orqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 7 VAL A 238
ASN A 239
ILE A 242
VAL A 196
 None
 0.66A 5bmvC-3orqA:
undetectable		 5bmvC-3orqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 PHE A 255
ALA A 234
LEU A 194
PHE A 206
ILE A 241
 None
 1.25A 5ljcA-3orqA:
undetectable		 5ljcA-3orqA:
15.62