SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3orw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 8 ALA A 189
HIS A 178
THR A 177
ILE A 202
 None
CO  A 328 (-3.3A)
None
None
 0.81A 1c9sI-3orwA:
undetectable
1c9sJ-3orwA:
undetectable		 1c9sI-3orwA:
14.98
1c9sJ-3orwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 5 HIS A  23
HIS A 178
HIS A 206
ASP A 266
 CO  A 327 (-3.3A)
CO  A 328 (-3.3A)
CO  A 328 (-3.4A)
CO  A 327 (-2.6A)
 0.81A 1e9yB-3orwA:
13.0		 1e9yB-3orwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		5 / 6 HIS A  23
HIS A  25
HIS A 178
HIS A 206
ASP A 266
 CO  A 327 (-3.3A)
CO  A 327 (-3.4A)
CO  A 328 (-3.3A)
CO  A 328 (-3.4A)
CO  A 327 (-2.6A)
 0.82A 1fweC-3orwA:
13.4		 1fweC-3orwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 7 GLN A 180
GLU A 103
MET A 236
ALA A 239
 None
 1.35A 1linA-3orwA:
undetectable		 1linA-3orwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		3 / 3 ASP A 266
HIS A 206
HIS A  23
 CO  A 327 (-2.6A)
CO  A 328 (-3.4A)
CO  A 327 (-3.3A)
 0.64A 1oe1A-3orwA:
undetectable		 1oe1A-3orwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		3 / 3 ASP A 266
HIS A 206
HIS A  23
 CO  A 327 (-2.6A)
CO  A 328 (-3.4A)
CO  A 327 (-3.3A)
 0.64A 1oe3A-3orwA:
undetectable		 1oe3A-3orwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 8 ALA A 189
HIS A 178
THR A 177
ILE A 202
 None
CO  A 328 (-3.3A)
None
None
 0.77A 1utdB-3orwA:
undetectable
1utdC-3orwA:
undetectable		 1utdB-3orwA:
14.98
1utdC-3orwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 8 ALA A 189
HIS A 178
THR A 177
ILE A 202
 None
CO  A 328 (-3.3A)
None
None
 0.80A 1utdF-3orwA:
undetectable
1utdG-3orwA:
undetectable		 1utdF-3orwA:
14.98
1utdG-3orwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 8 ALA A 189
HIS A 178
THR A 177
ILE A 202
 None
CO  A 328 (-3.3A)
None
None
 0.79A 1utdI-3orwA:
undetectable
1utdJ-3orwA:
undetectable		 1utdI-3orwA:
14.98
1utdJ-3orwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 6 LEU A  90
ILE A  63
ILE A 261
LEU A 323
 None
 0.87A 2xkwB-3orwA:
undetectable		 2xkwB-3orwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		3 / 3 ASP A 266
HIS A 206
HIS A  23
 CO  A 327 (-2.6A)
CO  A 328 (-3.4A)
CO  A 327 (-3.3A)
 0.67A 2xxgA-3orwA:
undetectable		 2xxgA-3orwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		3 / 3 ASP A 266
HIS A 206
HIS A  23
 CO  A 327 (-2.6A)
CO  A 328 (-3.4A)
CO  A 327 (-3.3A)
 0.68A 2xxgC-3orwA:
undetectable		 2xxgC-3orwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		3 / 3 ARG A 245
VAL A 291
THR A 267
 None
 0.81A 3cyxA-3orwA:
undetectable		 3cyxA-3orwA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 6 ILE A 204
TYR A 225
ILE A 176
HIS A 178
 None
None
None
CO  A 328 (-3.3A)
 1.12A 3eteA-3orwA:
undetectable
3eteE-3orwA:
undetectable		 3eteA-3orwA:
22.87
3eteE-3orwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 5 ILE A 204
TYR A 225
ILE A 176
HIS A 178
 None
None
None
CO  A 328 (-3.3A)
 1.11A 3eteB-3orwA:
undetectable
3eteC-3orwA:
undetectable		 3eteB-3orwA:
22.87
3eteC-3orwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 7 ILE A 176
HIS A 178
ILE A 204
TYR A 225
 None
CO  A 328 (-3.3A)
None
None
 1.11A 3eteD-3orwA:
undetectable
3eteF-3orwA:
undetectable		 3eteD-3orwA:
22.87
3eteF-3orwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		5 / 11 ALA A 167
PHE A 109
THR A  96
ILE A 144
ARG A 112
 None
None
None
KCX  A 145 ( 4.1A)
None
 1.28A 3n23A-3orwA:
undetectable		 3n23A-3orwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		3 / 3 TYR A 100
GLY A 104
ASP A  73
 None
 0.67A 3ou6C-3orwA:
undetectable		 3ou6C-3orwA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		3 / 3 ARG A 245
PRO A 213
PHE A 228
 None
 1.00A 3thrC-3orwA:
undetectable		 3thrC-3orwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 5 GLY A 185
THR A 219
ILE A 202
VAL A 224
 None
 0.92A 3wriA-3orwA:
undetectable		 3wriA-3orwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 5 HIS A  23
HIS A 178
HIS A 206
ASP A 266
 CO  A 327 (-3.3A)
CO  A 328 (-3.3A)
CO  A 328 (-3.4A)
CO  A 327 (-2.6A)
 0.74A 4h9mA-3orwA:
4.9		 4h9mA-3orwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		5 / 6 HIS A  23
HIS A  25
HIS A 178
HIS A 206
ASP A 266
 CO  A 327 (-3.3A)
CO  A 327 (-3.4A)
CO  A 328 (-3.3A)
CO  A 328 (-3.4A)
CO  A 327 (-2.6A)
 0.66A 4ubpC-3orwA:
13.0		 4ubpC-3orwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  18
LEU A  17
VAL A  12
VAL A 143
PHE A 324
 None
 1.11A 4wnwA-3orwA:
undetectable		 4wnwA-3orwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A 165
THR A 177
ASN A  72
THR A  96
LEU A 130
 None
 1.45A 4z7fC-3orwA:
undetectable		 4z7fC-3orwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 7 HIS A 290
GLY A 232
ASN A 288
HIS A 265
 None
 1.37A 5a5zC-3orwA:
undetectable		 5a5zC-3orwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		5 / 8 THR A 137
GLY A 138
GLY A 133
GLU A   6
ALA A 141
 None
 1.16A 5vw5A-3orwA:
undetectable		 5vw5A-3orwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3orw PHOSPHOTRIESTERASE
(Geobacillus
kaustophilus) 		4 / 5 THR A  70
HIS A  23
ASP A 266
HIS A 206
 None
CO  A 327 (-3.3A)
CO  A 327 (-2.6A)
CO  A 328 (-3.4A)
 1.12A 6dchA-3orwA:
undetectable		 6dchA-3orwA:
23.44