SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ory'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		5 / 12 GLY A  64
VAL A 308
LEU A 312
LEU A 142
ILE A  70
 None
 0.83A 1mx1D-3oryA:
undetectable		 1mx1D-3oryA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		4 / 6 LEU A 272
ASN A 229
ILE A 249
PHE A 246
 None
 1.20A 2jn3A-3oryA:
undetectable		 2jn3A-3oryA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		4 / 8 ILE A 338
ASN A 337
GLY A  76
ILE A  77
 None
 0.90A 3wxoA-3oryA:
undetectable		 3wxoA-3oryA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		5 / 12 TYR A 109
GLY A 116
ALA A 112
GLN A 114
LEU A 118
 None
 1.25A 4azwA-3oryA:
2.2		 4azwA-3oryA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		5 / 10 ALA A  35
PRO A  79
ILE A  77
LEU A  20
ILE A  72
 None
 1.20A 4dtaA-3oryA:
undetectable		 4dtaA-3oryA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		3 / 3 LYS A 187
LEU A 213
ALA A 172
 None
 0.67A 4iizA-3oryA:
undetectable		 4iizA-3oryA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		4 / 8 VAL A 165
VAL A  29
ILE A  28
LEU A 213
 None
 0.73A 4jq1B-3oryA:
undetectable		 4jq1B-3oryA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		4 / 6 VAL A 165
VAL A  29
ILE A  28
LEU A 213
 None
 0.79A 4l1wB-3oryA:
undetectable		 4l1wB-3oryA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3ory FLAP ENDONUCLEASE 1
(Desulfurococcus
amylolyticus) 		5 / 12 VAL A  -2
GLN A  38
LEU A 188
SER A 175
ASP A 177
 None
None
None
PO4  A 354 ( 4.1A)
PO4  A 354 (-2.8A)
 1.40A 4qdcA-3oryA:
undetectable		 4qdcA-3oryA:
24.60