SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3os4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		5 / 12 LEU A 154
THR A 187
SER A 190
LEU A 343
ALA A 146
 None
 1.11A 1ao8A-3os4A:
undetectable		 1ao8A-3os4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 7 HIS A 221
LEU A 370
SER A 371
ASP A 259
 None
 0.87A 1ismB-3os4A:
undetectable		 1ismB-3os4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 7 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 1.00A 1v55P-3os4A:
undetectable
1v55W-3os4A:
undetectable		 1v55P-3os4A:
20.76
1v55W-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		5 / 10 PHE A 174
GLU A 122
TYR A  18
ASP A 284
THR A 176
 None
 1.48A 2b82A-3os4A:
undetectable		 2b82A-3os4A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 7 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 1.00A 2dysC-3os4A:
undetectable
2dysJ-3os4A:
undetectable		 2dysC-3os4A:
20.76
2dysJ-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		5 / 7 PHE A 174
ARG A 177
ARG A 282
ASP A  16
TYR A  18
 None
 0.86A 2e5dA-3os4A:
6.5
2e5dB-3os4A:
6.5		 2e5dA-3os4A:
25.52
2e5dB-3os4A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		5 / 7 ASP A  16
TYR A  18
PHE A 174
ARG A 177
ARG A 282
 None
 0.85A 2e5dA-3os4A:
6.5
2e5dB-3os4A:
6.5		 2e5dA-3os4A:
25.52
2e5dB-3os4A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 6 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 1.06A 2einP-3os4A:
undetectable
2einW-3os4A:
undetectable		 2einP-3os4A:
20.76
2einW-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		5 / 6 PHE A 174
ARG A 177
SER A 203
GLY A 217
ARG A 282
 None
None
None
GOL  A 411 (-3.3A)
None
 0.46A 2f7fA-3os4A:
6.9		 2f7fA-3os4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 6 PHE A 174
SER A 203
GLY A 217
THR A 218
 None
None
GOL  A 411 (-3.3A)
FMT  A 414 (-2.8A)
 1.02A 2f7fA-3os4A:
6.9		 2f7fA-3os4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 8 LEU A 353
ARG A 136
VAL A  49
GLY A  48
 None
 1.05A 2qd5A-3os4A:
undetectable		 2qd5A-3os4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 6 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 0.95A 3ag1C-3os4A:
undetectable
3ag1J-3os4A:
undetectable		 3ag1C-3os4A:
20.76
3ag1J-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		5 / 10 GLU A 222
VAL A  26
GLN A  23
PHE A  91
PHE A  93
 GOL  A 418 (-2.9A)
None
None
None
None
 1.50A 4fgkA-3os4A:
undetectable
4fgkB-3os4A:
undetectable		 4fgkA-3os4A:
19.90
4fgkB-3os4A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 8 PHE A 174
ARG A 177
ARG A 282
TYR A  18
 None
 0.65A 4lv9A-3os4A:
5.0
4lv9B-3os4A:
2.4		 4lv9A-3os4A:
24.95
4lv9B-3os4A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		3 / 3 LEU A 335
ILE A 333
ARG A 332
 None
 0.63A 4mk4B-3os4A:
undetectable		 4mk4B-3os4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 5 ILE A 129
ARG A 136
ASP A  52
VAL A  98
 None
 1.20A 4nkxC-3os4A:
undetectable		 4nkxC-3os4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 5 ILE A 129
ARG A 136
ASP A  52
VAL A  98
 None
 1.22A 4nkxD-3os4A:
undetectable		 4nkxD-3os4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 7 LEU A 154
ASN A 158
LEU A 171
ILE A 166
 None
 0.81A 4ojbA-3os4A:
undetectable		 4ojbA-3os4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 6 LEU A 154
ASN A 158
LEU A 171
ILE A 166
 None
 0.84A 4okxA-3os4A:
undetectable		 4okxA-3os4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 6 GLU A  45
ILE A 355
HIS A 134
TYR A  50
 None
 1.08A 4qwpA-3os4A:
undetectable		 4qwpA-3os4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		3 / 3 THR A 233
ASN A 236
SER A 237
 None
 0.50A 4tvtA-3os4A:
undetectable		 4tvtA-3os4A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 7 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 0.89A 5b1bP-3os4A:
undetectable
5b1bW-3os4A:
undetectable		 5b1bP-3os4A:
20.76
5b1bW-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 8 LEU A 107
TYR A  50
VAL A  49
LEU A 353
 CL  A 417 (-4.7A)
None
None
None
 0.97A 5v0vA-3os4A:
undetectable		 5v0vA-3os4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		4 / 7 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 0.87A 5z84C-3os4A:
undetectable
5z84J-3os4A:
undetectable		 5z84C-3os4A:
20.76
5z84J-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		5 / 12 ASP A 108
LEU A 353
ARG A 137
ILE A 129
HIS A 103
 None
 1.28A 6ccvC-3os4A:
undetectable		 6ccvC-3os4A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Yersinia
pestis) 		3 / 3 LEU A  64
ASN A 204
LEU A  20
 None
 0.64A 6exiD-3os4A:
undetectable		 6exiD-3os4A:
12.05