SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3os6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 8 LEU A 149
ALA A 361
LEU A 359
THR A 190
 None
 0.78A 1dvtA-3os6A:
undetectable
1dvtB-3os6A:
undetectable		 1dvtA-3os6A:
17.13
1dvtB-3os6A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 4 VAL A 305
PHE A 328
SER A 146
VAL A 144
 None
 1.36A 1e7cA-3os6A:
undetectable		 1e7cA-3os6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 11 LEU A  58
ALA A 298
ALA A 296
VAL A  71
GLN A  55
 None
 1.27A 1hbpA-3os6A:
undetectable		 1hbpA-3os6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		7 / 11 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLY A 364
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-3.8A)
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.55A 1i7qA-3os6A:
36.1		 1i7qA-3os6A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		7 / 10 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLY A 364
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-3.8A)
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.57A 1i7qC-3os6A:
25.0		 1i7qC-3os6A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 VAL A 305
ALA A 304
HIS A 242
 None
 0.62A 1q23C-3os6A:
undetectable		 1q23C-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 VAL A 305
ALA A 304
HIS A 242
 None
 0.66A 1q23H-3os6A:
undetectable		 1q23H-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 VAL A 305
ALA A 304
HIS A 242
 None
 0.76A 1q23G-3os6A:
undetectable		 1q23G-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 VAL A 305
ALA A 304
HIS A 242
 None
 0.56A 1q23L-3os6A:
undetectable		 1q23L-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 VAL A 305
ALA A 304
HIS A 242
 None
 0.75A 1q23J-3os6A:
undetectable		 1q23J-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 VAL A 200
VAL A 345
TRP A 343
 None
 0.94A 1w5uA-3os6A:
undetectable
1w5uB-3os6A:
undetectable		 1w5uA-3os6A:
5.13
1w5uB-3os6A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 7 TYR A 124
THR A 378
VAL A 365
GLY A 364
 None
None
None
SO4  A 404 (-3.8A)
 0.96A 2a1mA-3os6A:
undetectable		 2a1mA-3os6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		7 / 11 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLY A 364
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-3.8A)
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.62A 2fn1A-3os6A:
41.7		 2fn1A-3os6A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		7 / 11 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLY A 364
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-3.8A)
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.65A 2fn1B-3os6A:
42.0		 2fn1B-3os6A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 VAL A 345
TRP A 343
VAL A 200
 None
 0.94A 2izqC-3os6A:
undetectable
2izqD-3os6A:
undetectable		 2izqC-3os6A:
5.13
2izqD-3os6A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 11 THR A 329
ALA A 361
GLY A 362
SER A 146
PHE A 382
 None
 1.21A 2xf3A-3os6A:
undetectable		 2xf3A-3os6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 11 THR A 329
ALA A 361
GLY A 362
SER A 146
PHE A 382
 None
 1.22A 2xf3B-3os6A:
undetectable		 2xf3B-3os6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 10 THR A 329
ALA A 361
GLY A 362
SER A 146
PHE A 382
 None
 1.20A 2xfsA-3os6A:
0.0		 2xfsA-3os6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 11 THR A 329
ALA A 361
GLY A 362
SER A 146
PHE A 382
 None
 1.23A 2xfsB-3os6A:
undetectable		 2xfsB-3os6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 8 LEU A 199
SER A 209
VAL A 249
ALA A 298
 None
 1.02A 3ax9A-3os6A:
undetectable		 3ax9A-3os6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 HIS A 242
GLU A 241
HIS A 240
 None
 0.82A 3ba0A-3os6A:
undetectable		 3ba0A-3os6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		6 / 12 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.63A 3r75A-3os6A:
17.9		 3r75A-3os6A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		6 / 12 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.63A 3r75B-3os6A:
38.6		 3r75B-3os6A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		6 / 11 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.62A 3r76A-3os6A:
38.5		 3r76A-3os6A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		6 / 11 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.63A 3r76B-3os6A:
38.4		 3r76B-3os6A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 7 THR A 175
GLY A 173
PRO A 196
ASN A 170
THR A 329
 None
 1.47A 3tajA-3os6A:
undetectable		 3tajA-3os6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 5 THR A 175
GLY A 173
PRO A 196
ASN A 170
 None
 1.14A 3u8qA-3os6A:
undetectable		 3u8qA-3os6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 12 PHE A  25
ASN A 179
ALA A 194
GLY A 193
ASN A 170
 None
 1.27A 3v3oB-3os6A:
undetectable		 3v3oB-3os6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 8 VAL A 249
TYR A 256
CYH A 257
VAL A 262
 None
 1.09A 4aftD-3os6A:
undetectable
4aftE-3os6A:
undetectable		 4aftD-3os6A:
17.93
4aftE-3os6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 12 LEU A 295
ALA A 296
LEU A 199
ILE A 344
LEU A  85
 None
None
None
None
SO4  A 405 ( 4.9A)
 1.04A 4dm8B-3os6A:
undetectable		 4dm8B-3os6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 8 ASN A 170
ALA A 167
LEU A  99
LEU A  97
 None
 0.92A 4jjkA-3os6A:
undetectable		 4jjkA-3os6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 7 GLY A 214
ASP A 238
GLY A 364
GLU A 374
 SO4  A 404 (-3.8A)
None
SO4  A 404 (-3.8A)
None
 0.88A 4koeA-3os6A:
undetectable
4koeB-3os6A:
undetectable
4koeD-3os6A:
undetectable		 4koeA-3os6A:
23.12
4koeB-3os6A:
23.12
4koeD-3os6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 9 LEU A 239
GLY A 214
ALA A 213
VAL A 246
ILE A 269
 None
SO4  A 404 (-3.8A)
SO4  A 404 (-3.9A)
None
None
 1.17A 4njtD-3os6A:
undetectable		 4njtD-3os6A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 7 GLY A 214
ASP A 238
GLY A 364
GLU A 374
 SO4  A 404 (-3.8A)
None
SO4  A 404 (-3.8A)
None
 0.86A 4z53A-3os6A:
undetectable
4z53B-3os6A:
undetectable		 4z53A-3os6A:
21.16
4z53B-3os6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 7 LEU A 232
VAL A 366
GLU A 374
SER A 369
 None
 1.31A 5umwA-3os6A:
undetectable
5umwF-3os6A:
0.1		 5umwA-3os6A:
11.28
5umwF-3os6A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 4 LEU A 253
LEU A 299
SER A 201
ALA A 296
 None
None
15P  A 408 ( 4.0A)
None
 1.13A 5uunA-3os6A:
undetectable		 5uunA-3os6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		3 / 3 GLY A 362
THR A 378
GLU A 377
 None
None
SO4  A 404 (-4.1A)
 0.60A 6b58A-3os6A:
undetectable		 6b58A-3os6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		5 / 9 ASP A 238
SER A 215
GLY A 131
VAL A 144
ILE A 143
 None
SO4  A 404 (-2.2A)
None
None
None
 1.42A 6giqA-3os6A:
undetectable
6giqE-3os6A:
undetectable
6giqI-3os6A:
undetectable		 6giqA-3os6A:
20.83
6giqE-3os6A:
17.17
6giqI-3os6A:
9.79