SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.15A 1ddsA-3ossD:
undetectable		 1ddsA-3ossD:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.12A 1dhfB-3ossD:
undetectable		 1dhfB-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.12A 1dyiA-3ossD:
undetectable		 1dyiA-3ossD:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.08A 1rx8A-3ossD:
undetectable		 1rx8A-3ossD:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 11 ILE D  41
ALA D   7
ILE D  18
VAL D  39
THR D  43
 None
 1.13A 2w3aA-3ossD:
undetectable		 2w3aA-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 10 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.14A 2w3aB-3ossD:
undetectable		 2w3aB-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.11A 2w3bA-3ossD:
undetectable		 2w3bA-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.11A 2w3bB-3ossD:
undetectable		 2w3bB-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.13A 2w3mA-3ossD:
undetectable		 2w3mA-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 LEU D  55
GLY D 132
SER D 150
ILE D  41
SER D  40
 None
 1.02A 3frqB-3ossD:
undetectable		 3frqB-3ossD:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		4 / 7 LEU D  60
TYR D  65
LYS D  76
ILE D  30
 None
 1.07A 3ik3B-3ossD:
undetectable		 3ik3B-3ossD:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		6 / 12 ILE D  41
ALA D   7
GLN D  54
LEU D  60
VAL D  39
THR D  43
 None
 1.25A 3ix9B-3ossD:
undetectable		 3ix9B-3ossD:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 11 ALA D   7
ILE D  18
LEU D  60
VAL D  39
THR D  43
 None
 0.99A 3n0hA-3ossD:
undetectable		 3n0hA-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3oss TYPE 2 SECRETION
SYSTEM, GSPC
TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 11 ALA C 133
PHE D   9
ILE D  18
GLY D  22
ALA D  23
 None
 1.20A 3rukD-3ossC:
undetectable		 3rukD-3ossC:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ALA D   7
ILE D  18
LEU D  60
VAL D  39
THR D  43
 None
 1.04A 3s3vA-3ossD:
undetectable		 3s3vA-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 11 ILE D 126
ALA D 129
GLY D 130
GLY D 100
ASN D 133
 None
 1.14A 4jdsA-3ossD:
undetectable		 4jdsA-3ossD:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.11A 4kebB-3ossD:
undetectable		 4kebB-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		6 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
VAL D  39
THR D  43
 None
 1.10A 4kfjB-3ossD:
undetectable		 4kfjB-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.08A 4m6kA-3ossD:
undetectable		 4m6kA-3ossD:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.15A 4rgcA-3ossD:
undetectable		 4rgcA-3ossD:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.14A 4x5fA-3ossD:
undetectable		 4x5fA-3ossD:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		5 / 12 ILE D  41
ALA D   7
ILE D  18
LEU D  60
THR D  43
 None
 1.13A 4x5fB-3ossD:
undetectable		 4x5fB-3ossD:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3oss TYPE 2 SECRETION
SYSTEM, GSPC
TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		4 / 8 TYR C 151
ILE C 167
GLY C 131
THR D  12
 None
 0.93A 5esfA-3ossC:
undetectable		 5esfA-3ossC:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3oss TYPE 2 SECRETION
SYSTEM, GSPC
TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		4 / 7 TYR C 151
ILE C 167
GLY C 131
THR D  12
 None
 0.94A 5esmA-3ossC:
undetectable		 5esmA-3ossC:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD
(Escherichia
coli) 		3 / 3 ASN D 133
ASP D 101
GLY D 100
 None
 0.54A 5fctB-3ossD:
undetectable		 5fctB-3ossD:
18.33