SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3osu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 SER A 141
VAL A 142
TYR A 154
GLY A 185
LEU A 199
 PEG  A 247 ( 4.5A)
None
PEG  A 247 (-4.2A)
None
None
 1.11A 1fduA-3osuA:
27.0		 1fduA-3osuA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 11 LYS A 166
SER A 140
ALA A 159
GLY A 144
ALA A 145
 None
 1.37A 2xh9A-3osuA:
undetectable		 2xh9A-3osuA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 10 LYS A 166
SER A 140
ALA A 159
GLY A 144
ALA A 145
 None
 1.36A 2xh9B-3osuA:
undetectable		 2xh9B-3osuA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLN A 206
TYR A 154
ILE A 187
GLY A 185
GLY A 213
 None
PEG  A 247 (-4.2A)
None
None
None
 1.00A 3bwcA-3osuA:
5.7		 3bwcA-3osuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 THR A  10
ASN A  88
ALA A  32
ILE A 121
MET A 128
 None
 1.28A 3dl9B-3osuA:
undetectable		 3dl9B-3osuA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		4 / 5 SER A 141
ILE A  16
TYR A 154
GLY A 185
 PEG  A 247 ( 4.5A)
None
PEG  A 247 (-4.2A)
None
 1.04A 3uboB-3osuA:
6.7		 3uboB-3osuA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 8 LEU A 204
ILE A 207
ASN A 241
GLY A 185
ILE A 187
 None
 0.99A 3wxoA-3osuA:
undetectable		 3wxoA-3osuA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 ALA A  21
GLN A  23
ILE A 137
LEU A   8
VAL A  85
 None
 1.17A 4azwA-3osuA:
5.6		 4azwA-3osuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Staphylococcus
aureus) 		5 / 12 LEU A 139
GLY A  11
ASN A 119
ASN A 113
VAL A 161
 MG  A 257 ( 4.8A)
PEG  A 250 ( 3.9A)
None
None
None
 1.14A 5d0yA-3osuA:
undetectable		 5d0yA-3osuA:
22.48