SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ot1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 11 LEU B 179
LEU B  29
ALA B 106
ALA B  73
LEU B 174
 None
 1.30A 1iiuA-3ot1B:
undetectable		 1iiuA-3ot1B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 10 LEU B 103
ALA B 167
VAL B  36
VAL B  11
PRO B  12
 None
 0.99A 2nnjA-3ot1B:
undetectable		 2nnjA-3ot1B:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 12 LEU B 168
GLY B 176
LEU B 173
LEU B 197
LEU B 194
 None
 0.73A 2nxeA-3ot1B:
3.6		 2nxeA-3ot1B:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		4 / 7 GLY B 199
ALA B 169
ALA B 172
VAL B 146
 None
 0.74A 3a2qA-3ot1B:
undetectable		 3a2qA-3ot1B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 12 LEU B 168
GLY B 176
LEU B 173
LEU B 197
LEU B 194
 None
 0.78A 3cjtG-3ot1B:
4.2		 3cjtG-3ot1B:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 12 LEU B 168
GLY B 176
LEU B 173
LEU B 197
LEU B 194
 None
 0.77A 3cjtO-3ot1B:
4.2		 3cjtO-3ot1B:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		4 / 8 GLY B  52
GLY B  49
GLY B  16
HIS B  15
 None
 0.70A 3d41A-3ot1B:
undetectable		 3d41A-3ot1B:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 9 LEU B 174
GLY B  33
ALA B  32
VAL B  26
ILE B 171
 None
 0.96A 3oxvA-3ot1B:
undetectable		 3oxvA-3ot1B:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 9 LEU B 174
GLY B  33
ALA B  32
VAL B  26
ILE B 171
 None
 0.99A 3oxvC-3ot1B:
undetectable		 3oxvC-3ot1B:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		4 / 7 HIS B  15
GLY B  80
ALA B  83
PHE B  84
 None
 0.92A 3tehB-3ot1B:
undetectable		 3tehB-3ot1B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		4 / 6 LEU B 141
PHE B 133
ASP B 134
HIS B 129
 None
None
None
CSX  B 108 ( 4.3A)
 1.21A 5om3A-3ot1B:
undetectable
5om3B-3ot1B:
undetectable		 5om3A-3ot1B:
19.70
5om3B-3ot1B:
10.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		8 / 10 GLU B  21
GLY B  76
GLY B  77
ILE B 107
ALA B 109
PRO B 111
HIS B 129
GLY B 159
 CSX  B 108 ( 3.0A)
CSX  B 108 ( 3.2A)
CSX  B 108 (-3.4A)
CSX  B 108 ( 3.4A)
CSX  B 108 ( 3.7A)
CSX  B 108 ( 4.2A)
CSX  B 108 ( 4.3A)
CSX  B 108 ( 3.6A)
 0.34A 6e5zA-3ot1B:
30.5		 6e5zA-3ot1B:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		5 / 11 ILE B   9
LEU B 173
GLY B 176
PHE B  34
ALA B  32
 None
 1.33A 6ieyA-3ot1B:
3.7
6ieyB-3ot1B:
2.8		 6ieyA-3ot1B:
21.04
6ieyB-3ot1B:
21.04