SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ot6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 LEU A 143
ALA A 107
GLY A  60
ILE A  26
 None
 0.67A 1d4yB-3ot6A:
undetectable		 1d4yB-3ot6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 SER A   6
LEU A 110
VAL A  50
PHE A  34
ILE A  26
 None
 1.49A 1uobA-3ot6A:
undetectable		 1uobA-3ot6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 SER A 156
ALA A 171
GLY A 172
LEU A 148
VAL A 103
 None
 0.91A 1vpoH-3ot6A:
undetectable
1vpoL-3ot6A:
undetectable		 1vpoH-3ot6A:
21.43
1vpoL-3ot6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLN A  79
VAL A  30
LEU A   4
GLY A  60
ALA A  25
 None
 1.08A 3kk6A-3ot6A:
undetectable		 3kk6A-3ot6A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3ot6 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 12 GLU A 129
LEU A  88
LEU A 217
ALA A 139
ARG A 116
GLY A 106
 None
 1.42A 6b0cD-3ot6A:
undetectable		 6b0cD-3ot6A:
17.29