SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3otd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ASN A 137
TRP A  23
GLN A 138
 None
 1.08A 1xoqA-3otdA:
undetectable		 1xoqA-3otdA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ASP A  67
GLU A 267
ARG A  84
LYS A  83
 None
 0.98A 1yc2A-3otdA:
undetectable
1yc2B-3otdA:
undetectable
1yc2E-3otdA:
undetectable		 1yc2A-3otdA:
20.63
1yc2B-3otdA:
20.63
1yc2E-3otdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLU A  38
GLN A 119
ARG A  49
 None
 0.97A 2w3bB-3otdA:
undetectable		 2w3bB-3otdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ASP A 251
GLY A 209
THR A 210
PHE A 257
 None
None
IOD  A 270 ( 4.6A)
None
 0.68A 4ac9C-3otdA:
undetectable		 4ac9C-3otdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ASP A 251
GLY A 209
THR A 210
PHE A 257
 None
None
IOD  A 270 ( 4.6A)
None
 0.69A 4acaC-3otdA:
undetectable		 4acaC-3otdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		4 / 5 TYR A  78
THR A  60
PHE A 104
ILE A  68
 None
 1.25A 4jx1E-3otdA:
undetectable		 4jx1E-3otdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 MET A  97
ALA A 101
LEU A  65
ILE A  68
TYR A 143
 None
 1.28A 5vlmA-3otdA:
undetectable		 5vlmA-3otdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLU A 189
LEU A 170
VAL A 160
SER A 193
ILE A 190
 None
 1.03A 5vopA-3otdA:
undetectable		 5vopA-3otdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens) 		4 / 8 THR A 210
CYH A 151
TYR A  72
LEU A  51
 IOD  A 270 ( 4.6A)
None
None
None
 1.22A 6cnjD-3otdA:
undetectable
6cnjE-3otdA:
undetectable		 6cnjD-3otdA:
14.66
6cnjE-3otdA:
13.41