SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 GLY A 333
HIS A 335
ALA A 326
THR A 301
GLY A 296
 None
 1.13A 1c9sP-3othA:
undetectable
1c9sQ-3othA:
undetectable		 1c9sP-3othA:
9.18
1c9sQ-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3oth CALG1
(Micromonospora
echinospora) 		4 / 8 GLY A 124
ASN A 120
GLY A 122
VAL A  51
 None
 0.93A 1dbbH-3othA:
undetectable
1dbbL-3othA:
undetectable		 1dbbH-3othA:
20.98
1dbbL-3othA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3oth CALG1
(Micromonospora
echinospora) 		5 / 10 GLY A 296
GLY A 333
HIS A 335
ALA A 326
THR A 301
 None
 1.15A 1gtfJ-3othA:
undetectable
1gtfK-3othA:
undetectable		 1gtfJ-3othA:
9.18
1gtfK-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 GLY A 333
HIS A 335
ALA A 326
THR A 301
GLY A 296
 None
 1.12A 1gtfQ-3othA:
undetectable
1gtfR-3othA:
undetectable		 1gtfQ-3othA:
9.18
1gtfR-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 GLY A 333
HIS A 335
ALA A 326
THR A 301
GLY A 296
 None
 1.11A 1gtfS-3othA:
undetectable
1gtfT-3othA:
undetectable		 1gtfS-3othA:
9.18
1gtfT-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 GLY A 333
HIS A 335
ALA A 326
THR A 301
GLY A 296
 None
 1.14A 1gtnT-3othA:
undetectable
1gtnU-3othA:
undetectable		 1gtnT-3othA:
9.18
1gtnU-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 6 SER A 119
PHE A 178
GLU A 117
GLY A 138
 CLJ  A 394 (-3.6A)
None
None
None
 1.09A 1icuA-3othA:
undetectable
1icuB-3othA:
undetectable		 1icuA-3othA:
20.58
1icuB-3othA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 6 PHE A 178
GLU A 117
GLY A 138
SER A 119
 None
None
None
CLJ  A 394 (-3.6A)
 1.05A 1icuA-3othA:
undetectable
1icuB-3othA:
undetectable		 1icuA-3othA:
20.58
1icuB-3othA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 6 SER A 119
PHE A 178
GLU A 117
GLY A 138
 CLJ  A 394 (-3.6A)
None
None
None
 1.07A 1icuC-3othA:
undetectable
1icuD-3othA:
undetectable		 1icuC-3othA:
20.58
1icuD-3othA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 9 THR A  53
GLY A  54
LEU A 102
GLU A 101
GLY A 122
 None
 1.19A 1jhoA-3othA:
2.8		 1jhoA-3othA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 9 THR A  53
GLY A  54
LEU A 102
GLU A 101
GLY A 122
 None
 1.19A 1jhrA-3othA:
3.8		 1jhrA-3othA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 6 SER A 119
PHE A 178
GLU A 117
GLY A 138
 CLJ  A 394 (-3.6A)
None
None
None
 1.14A 1kqbA-3othA:
undetectable
1kqbB-3othA:
undetectable		 1kqbA-3othA:
19.64
1kqbB-3othA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 6 SER A 119
PHE A 178
GLU A 117
GLY A 138
 CLJ  A 394 (-3.6A)
None
None
None
 1.09A 1kqbC-3othA:
undetectable
1kqbD-3othA:
undetectable		 1kqbC-3othA:
19.64
1kqbD-3othA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 9 THR A  53
GLY A  54
LEU A 102
GLU A 101
GLY A 122
 None
 1.19A 1l5lA-3othA:
undetectable		 1l5lA-3othA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 10 GLY A 333
HIS A 335
ALA A 326
THR A 301
GLY A 296
 None
 1.14A 1utdH-3othA:
undetectable
1utdI-3othA:
undetectable		 1utdH-3othA:
9.18
1utdI-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 GLY A 333
HIS A 335
ALA A 326
THR A 301
GLY A 296
 None
 1.13A 1utdS-3othA:
undetectable
1utdT-3othA:
undetectable		 1utdS-3othA:
9.18
1utdT-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 GLY A 296
GLY A 333
HIS A 335
ALA A 326
THR A 301
 None
 1.12A 1utdL-3othA:
undetectable
1utdV-3othA:
undetectable		 1utdL-3othA:
9.18
1utdV-3othA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 7 VAL A  31
THR A  32
PHE A  48
ARG A  44
 None
 1.19A 2kotA-3othA:
undetectable		 2kotA-3othA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 SER A 232
PHE A 321
GLY A 296
HIS A 295
THR A 301
 CLJ  A 394 ( 4.2A)
None
None
TYD  A 393 (-3.9A)
None
 1.50A 3a25A-3othA:
4.4		 3a25A-3othA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3oth CALG1
(Micromonospora
echinospora) 		3 / 3 PRO A 144
THR A 143
LEU A 147
 None
 0.74A 3ttrA-3othA:
undetectable		 3ttrA-3othA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 GLY A 296
GLY A 297
THR A 231
GLY A 318
ASP A 319
 None
TYD  A 393 (-3.6A)
TYD  A 393 (-3.1A)
CLJ  A 394 (-3.8A)
None
 0.95A 3uboA-3othA:
6.9		 3uboA-3othA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 6 GLY A 246
ASP A 334
ASP A 344
ASN A 340
 None
 0.99A 3vywC-3othA:
2.2		 3vywC-3othA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 PHE A 314
LEU A 247
GLY A 246
ILE A 341
 None
 0.81A 3wrkA-3othA:
undetectable		 3wrkA-3othA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 8 GLY A 249
ASP A 245
GLY A 246
VAL A 254
 None
 0.79A 4c5nC-3othA:
6.5		 4c5nC-3othA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 8 GLN A 282
PHE A 182
ILE A 370
VAL A 366
 TYD  A 393 (-3.5A)
None
None
None
 0.90A 4dx7B-3othA:
undetectable		 4dx7B-3othA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 7 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 0.97A 4pfjA-3othA:
4.2		 4pfjA-3othA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 122
ALA A 123
LEU A 102
 None
 1.18A 4rrwA-3othA:
undetectable		 4rrwA-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 124
ALA A 123
LEU A 102
 None
 1.17A 4rrwA-3othA:
undetectable		 4rrwA-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 124
ALA A 123
LEU A 102
 None
 1.16A 4rrwB-3othA:
undetectable		 4rrwB-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 122
ALA A 123
LEU A 102
 None
 1.07A 4rrwD-3othA:
undetectable		 4rrwD-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 122
ALA A 123
LEU A 102
 None
 1.18A 4rrzA-3othA:
undetectable		 4rrzA-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 124
ALA A 123
LEU A 102
 None
 1.17A 4rrzA-3othA:
undetectable		 4rrzA-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 124
ALA A 123
LEU A 102
 None
 1.16A 4rrzB-3othA:
undetectable		 4rrzB-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A   8
SER A   7
GLY A 122
ALA A 123
LEU A 102
 None
 1.07A 4rrzD-3othA:
undetectable		 4rrzD-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 9 LEU A   8
SER A   7
GLY A 122
ALA A 123
LEU A 102
 None
 1.01A 4rs0A-3othA:
undetectable		 4rs0A-3othA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLY A 230
THR A 231
HIS A 295
GLY A 299
 TYD  A 393 ( 3.7A)
TYD  A 393 (-3.1A)
TYD  A 393 (-3.9A)
TYD  A 393 (-3.6A)
 1.03A 4v20A-3othA:
undetectable		 4v20A-3othA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.10A 5hm8A-3othA:
6.8		 5hm8A-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.09A 5hm8B-3othA:
7.4		 5hm8B-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.09A 5hm8C-3othA:
6.9		 5hm8C-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.10A 5hm8D-3othA:
7.2		 5hm8D-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.10A 5hm8E-3othA:
3.6		 5hm8E-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.09A 5hm8F-3othA:
3.4		 5hm8F-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.10A 5hm8G-3othA:
3.4		 5hm8G-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.09A 5hm8H-3othA:
3.8		 5hm8H-3othA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oth CALG1
(Micromonospora
echinospora) 		6 / 12 VAL A 380
VAL A 115
LEU A  43
VAL A  31
ALA A  21
LEU A  20
 None
 1.46A 5iktA-3othA:
undetectable		 5iktA-3othA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 ALA A  23
THR A  22
ALA A  21
GLY A  28
ALA A  27
 None
 1.04A 5lf3K-3othA:
undetectable
5lf3L-3othA:
undetectable		 5lf3K-3othA:
19.42
5lf3L-3othA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 11 ALA A  23
THR A  22
ALA A  21
GLY A  28
ALA A  27
 None
 1.03A 5lf3Y-3othA:
undetectable
5lf3Z-3othA:
undetectable		 5lf3Y-3othA:
19.42
5lf3Z-3othA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 4 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.11A 5v96A-3othA:
4.7		 5v96A-3othA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 4 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.10A 5v96B-3othA:
4.9		 5v96B-3othA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 4 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.15A 5v96D-3othA:
6.9		 5v96D-3othA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 ALA A 243
LEU A 291
ARG A 218
VAL A 274
ASP A 251
 None
 1.20A 5vlmD-3othA:
undetectable		 5vlmD-3othA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 ALA A 304
VAL A 327
ALA A 349
LEU A 250
LEU A 247
 None
 1.08A 5xxiA-3othA:
undetectable		 5xxiA-3othA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 LEU A 147
ILE A 151
PHE A  61
VAL A 239
LEU A 262
 None
None
CLJ  A 394 ( 4.0A)
None
None
 1.04A 6a7pA-3othA:
undetectable		 6a7pA-3othA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 VAL A 346
ALA A 349
GLY A 348
LEU A 250
LEU A 247
 None
 1.09A 6f6iA-3othA:
undetectable
6f6iB-3othA:
undetectable		 6f6iA-3othA:
11.49
6f6iB-3othA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 6 ASP A 145
ARG A 170
GLU A 152
CYH A 136
 None
 1.50A 6mn5D-3othA:
1.6		 6mn5D-3othA:
12.20