SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3otn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 SER A 210
VAL A 209
ASN A 269
VAL A 381
PHE A 144
 None
 1.42A 1a27A-3otnA:
undetectable		 1a27A-3otnA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 ARG A 325
LEU A 255
LEU A 262
ILE A 413
GLY A 415
 None
 1.02A 1cqeA-3otnA:
0.5		 1cqeA-3otnA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 ARG A 325
LEU A 255
LEU A 262
ILE A 413
GLY A 415
 None
 1.03A 1cqeB-3otnA:
undetectable		 1cqeB-3otnA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 GLN A  92
TYR A 102
LEU A 309
SER A  86
 None
 1.12A 1hk3A-3otnA:
undetectable		 1hk3A-3otnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 SER A 375
VAL A 289
SER A 288
ASN A  67
 None
 1.15A 1hwiB-3otnA:
undetectable		 1hwiB-3otnA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 SER A 375
VAL A 289
SER A 288
ASN A  67
 None
 1.14A 1hwkA-3otnA:
undetectable		 1hwkA-3otnA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 SER A 375
VAL A 289
SER A 288
ASN A  67
 None
 1.14A 1hwkC-3otnA:
undetectable		 1hwkC-3otnA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 SER A 375
VAL A 289
SER A 288
ASN A  67
 None
 1.14A 1hwkD-3otnA:
undetectable		 1hwkD-3otnA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 7 ARG A 414
PHE A 440
ASP A 323
GLU A 320
 None
None
None
ACT  A 609 (-4.3A)
 1.11A 2qebB-3otnA:
undetectable		 2qebB-3otnA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 LEU A 377
ASN A 286
GLN A 276
VAL A 381
ILE A  69
 None
 1.39A 3h52A-3otnA:
undetectable		 3h52A-3otnA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 10 VAL A 160
VAL A 180
LEU A 230
TYR A 150
GLY A 158
 None
 1.27A 3ls4H-3otnA:
undetectable		 3ls4H-3otnA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 ARG A 325
LEU A 255
LEU A 262
ILE A 413
GLY A 415
 None
 1.12A 3n8xB-3otnA:
0.1		 3n8xB-3otnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 THR A  47
ASN A  48
GLU A 141
 None
EDO  A 634 ( 3.9A)
None
 0.77A 3v4tA-3otnA:
undetectable
3v4tC-3otnA:
undetectable		 3v4tA-3otnA:
22.33
3v4tC-3otnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 ASN A 475
TRP A 476
ASP A 460
 None
 1.23A 4a7tA-3otnA:
undetectable
4a7tF-3otnA:
undetectable		 4a7tA-3otnA:
15.49
4a7tF-3otnA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 6 ARG A 325
GLU A 445
LEU A 262
ASP A 441
 None
 1.39A 4cevA-3otnA:
undetectable
4cevB-3otnA:
undetectable		 4cevA-3otnA:
20.59
4cevB-3otnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 6 ASP A 441
ARG A 325
GLU A 445
LEU A 262
 None
 1.38A 4cevA-3otnA:
undetectable
4cevC-3otnA:
undetectable		 4cevA-3otnA:
20.59
4cevC-3otnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 6 ARG A 325
GLU A 445
LEU A 262
ASP A 441
 None
 1.41A 4cevD-3otnA:
undetectable
4cevE-3otnA:
undetectable		 4cevD-3otnA:
20.59
4cevE-3otnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 6 ARG A 325
GLU A 445
LEU A 262
ASP A 441
 None
 1.41A 4cevE-3otnA:
undetectable
4cevF-3otnA:
undetectable		 4cevE-3otnA:
20.59
4cevF-3otnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 8 GLY A 227
MET A 390
GLU A 393
ALA A 394
 None
 0.88A 4rjdA-3otnA:
undetectable
4rjdB-3otnA:
undetectable		 4rjdA-3otnA:
8.51
4rjdB-3otnA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 10 PHE A 202
ALA A 216
VAL A 387
TYR A 384
GLY A 212
 None
None
None
EDO  A 632 (-4.7A)
None
 1.30A 4xp1A-3otnA:
undetectable		 4xp1A-3otnA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 THR A 425
ALA A 429
ASN A 426
 None
 0.50A 5ersA-3otnA:
undetectable		 5ersA-3otnA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 ALA A 213
TYR A 382
TYR A 184
GLY A 233
PHE A 151
 None
 1.03A 5fsaA-3otnA:
undetectable		 5fsaA-3otnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 6 TYR A 184
ILE A 156
TYR A 152
TYR A 382
 None
 1.25A 5igyA-3otnA:
undetectable		 5igyA-3otnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		4 / 4 TYR A 222
SER A 240
GLU A 393
ASP A 220
 None
 1.31A 5lsaA-3otnA:
undetectable		 5lsaA-3otnA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		5 / 12 SER A 203
ALA A 216
TYR A  51
ALA A 213
GLY A 212
 None
None
EDO  A 634 ( 4.1A)
None
None
 1.02A 5tzoB-3otnA:
undetectable		 5tzoB-3otnA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 LEU A 200
THR A 206
ASN A 269
 None
 0.55A 6baaE-3otnA:
undetectable		 6baaE-3otnA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 LEU A 200
THR A 206
ASN A 269
 None
 0.55A 6baaF-3otnA:
undetectable		 6baaF-3otnA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 LEU A 200
THR A 206
ASN A 269
 None
 0.55A 6baaG-3otnA:
undetectable		 6baaG-3otnA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3otn SUSD SUPERFAMILY
PROTEIN
(Parabacteroides
distasonis) 		3 / 3 LEU A 200
THR A 206
ASN A 269
 None
 0.55A 6baaH-3otnA:
undetectable		 6baaH-3otnA:
14.57