SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3otr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 PHE A 392
LEU A 396
LEU A 354
ILE A  89
ILE A 366
 None
 0.97A 1crbA-3otrA:
undetectable		 1crbA-3otrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 3otr ENOLASE
(Toxoplasma
gondii) 		3 / 3 PHE A 251
TRP A 293
GLU A 228
 None
 1.18A 1mogA-3otrA:
undetectable		 1mogA-3otrA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 4 SER A 120
VAL A  23
PHE A 392
VAL A 356
 None
 1.26A 1o86A-3otrA:
undetectable		 1o86A-3otrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 TYR A 419
ILE A 177
PRO A 179
ALA A 188
 None
 1.03A 1oniD-3otrA:
undetectable
1oniE-3otrA:
undetectable		 1oniD-3otrA:
15.90
1oniE-3otrA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 6 SER A 120
ALA A 365
THR A 335
ALA A  47
 None
 0.97A 1w0gA-3otrA:
undetectable		 1w0gA-3otrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 LEU A 352
LEU A 354
LEU A 396
ILE A 340
LEU A 142
 None
 1.07A 2pnjA-3otrA:
undetectable		 2pnjA-3otrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 8 PHE A 251
LEU A 281
ALA A 253
PHE A 258
 None
 0.85A 2vcvP-3otrA:
undetectable		 2vcvP-3otrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 GLY A  17
ILE A  12
LEU A  59
LYS A  61
VAL A  63
 None
 1.14A 3fzgA-3otrA:
undetectable		 3fzgA-3otrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 VAL A  23
ILE A  89
THR A 363
GLY A 118
 None
 0.92A 3gssA-3otrA:
undetectable		 3gssA-3otrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 VAL A  23
ILE A  89
THR A 363
GLY A 118
 None
 0.98A 3gssB-3otrA:
undetectable		 3gssB-3otrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 GLY A  43
ALA A  40
GLN A 358
ARG A 339
ILE A  44
 None
 1.11A 4azwA-3otrA:
undetectable		 4azwA-3otrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 LEU A 352
LEU A 353
ILE A 393
ILE A 405
LEU A 400
 None
 1.22A 4j24C-3otrA:
undetectable		 4j24C-3otrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 LEU A 352
LEU A 353
ILE A 393
ILE A 405
LEU A 400
 None
 1.15A 4j26B-3otrA:
undetectable		 4j26B-3otrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 11 ALA A 253
GLU A 174
GLY A 169
ASN A 168
TYR A 270
 None
 1.38A 4jdsD-3otrA:
undetectable		 4jdsD-3otrA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 11 LEU A 172
TYR A 290
VAL A 302
ILE A 299
PHE A 175
 None
 1.34A 4lhmA-3otrA:
undetectable		 4lhmA-3otrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 TYR A 138
ALA A 129
GLY A 132
GLY A  29
PHE A  32
 None
 0.94A 4obwB-3otrA:
undetectable		 4obwB-3otrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 8 ASN A 168
GLU A 257
GLY A 163
SER A 385
 None
 0.85A 4r20A-3otrA:
undetectable		 4r20A-3otrA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 8 GLY A 408
GLU A 217
GLU A 303
ALA A 250
 None
 0.85A 4rjdA-3otrA:
undetectable
4rjdB-3otrA:
undetectable		 4rjdA-3otrA:
10.21
4rjdB-3otrA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 GLY A 112
MET A  93
ALA A  66
ILE A  21
 None
 0.86A 4txnA-3otrA:
undetectable		 4txnA-3otrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 GLY A 112
MET A  93
ALA A  66
ILE A  21
 None
 0.86A 4txnB-3otrA:
undetectable		 4txnB-3otrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 GLY A 112
MET A  93
ALA A  66
ILE A  21
 None
 0.85A 4txnC-3otrA:
undetectable		 4txnC-3otrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 GLY A 112
MET A  93
ALA A  66
ILE A  21
 None
 0.86A 4txnD-3otrA:
undetectable		 4txnD-3otrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 7 ARG A  16
SER A 385
GLU A 174
GLU A 217
 None
 1.42A 4xzkA-3otrA:
undetectable		 4xzkA-3otrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 5 VAL A 302
VAL A 321
GLY A 322
PHE A 317
 None
 0.94A 5d4nA-3otrA:
undetectable
5d4nC-3otrA:
undetectable		 5d4nA-3otrA:
11.99
5d4nC-3otrA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 ILE A   7
PHE A  32
GLY A 118
ALA A 129
ASP A  24
 None
 1.06A 5e72A-3otrA:
undetectable		 5e72A-3otrA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 11 ALA A 365
VAL A 381
LEU A 400
LEU A 370
VAL A 379
 None
 1.21A 5eb5A-3otrA:
undetectable		 5eb5A-3otrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 PHE A 392
LEU A 396
LEU A 354
ILE A  89
ILE A 366
 None
 1.13A 5h8tA-3otrA:
undetectable		 5h8tA-3otrA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 ILE A 359
GLY A 360
VAL A  36
ALA A 365
ALA A 368
 None
 1.03A 5n0oB-3otrA:
undetectable		 5n0oB-3otrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3otr ENOLASE
(Toxoplasma
gondii) 		5 / 12 ILE A 359
GLY A 360
VAL A  36
ALA A 365
ALA A 368
 None
 1.02A 5n0tB-3otrA:
undetectable		 5n0tB-3otrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 6 GLY A 112
LEU A 111
VAL A 356
PHE A 392
 None
 0.95A 6h7lA-3otrA:
undetectable		 6h7lA-3otrA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 6 GLY A 112
LEU A 111
VAL A 356
PHE A 392
 None
 0.95A 6h7lB-3otrA:
undetectable		 6h7lB-3otrA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3otr ENOLASE
(Toxoplasma
gondii) 		4 / 6 SER A 120
ALA A 365
THR A 335
ALA A  47
 None
 1.05A 6ma6A-3otrA:
undetectable		 6ma6A-3otrA:
12.11