SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3otx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		11 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ALA A 136
LEU A 138
PHE A 169
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
None
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.29A 1bx4A-3otxA:
49.7		 1bx4A-3otxA:
40.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		9 / 12 THR A 264
THR A 270
VAL A 283
GLN A 288
ALA A 297
GLY A 298
HIS A 323
ALA A 326
ILE A 330
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.5A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 (-3.8A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
 0.58A 1bx4A-3otxA:
49.7		 1bx4A-3otxA:
40.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 ASN A  13
ASP A  17
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.45A 1dgmA-3otxA:
40.3		 1dgmA-3otxA:
34.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 ASP A  17
GLY A  63
ASN A  67
CYH A 123
ASP A 299
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 ( 3.2A)
 0.65A 1dgmA-3otxA:
40.3		 1dgmA-3otxA:
34.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 ASP A  17
GLY A  63
ASN A  67
CYH A 123
LEU A 134
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 ( 4.4A)
 0.69A 1dgmA-3otxA:
40.3		 1dgmA-3otxA:
34.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 THR A 270
PRO A 282
THR A 280
 AP5  A 346 (-4.5A)
None
None
 0.83A 1i3wE-3otxA:
undetectable		 1i3wE-3otxA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A 321
TYR A 324
ILE A 330
ILE A 108
ALA A  69
 None
None
AP5  A 346 (-4.9A)
None
None
 1.00A 1jtxA-3otxA:
undetectable		 1jtxA-3otxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A 144
LEU A 138
ALA A 124
ALA A 136
VAL A 173
 None
None
None
AP5  A 346 (-3.5A)
None
 1.34A 1kt4A-3otxA:
undetectable		 1kt4A-3otxA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		9 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
None
AP5  A 346 ( 3.2A)
 0.35A 1liiA-3otxA:
45.1		 1liiA-3otxA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 ( 3.2A)
 0.41A 1likA-3otxA:
44.8		 1likA-3otxA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 THR A 264
VAL A 283
ALA A 297
ALA A 326
GLN A 327
ILE A 330
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.1A)
AP5  A 346 (-4.9A)
 0.48A 1likA-3otxA:
44.8		 1likA-3otxA:
34.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 THR A 270
PRO A 282
THR A 280
 AP5  A 346 (-4.5A)
None
None
 0.89A 1ovfB-3otxA:
undetectable		 1ovfB-3otxA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.97A 1p6kA-3otxA:
undetectable		 1p6kA-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.96A 1p6kB-3otxA:
undetectable		 1p6kB-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 1.00A 1rs6A-3otxA:
undetectable		 1rs6A-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.96A 1rs6B-3otxA:
undetectable		 1rs6B-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 1.00A 1rs7B-3otxA:
undetectable		 1rs7B-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.95A 1zzqA-3otxA:
undetectable		 1zzqA-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.93A 1zzqB-3otxA:
undetectable		 1zzqB-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.96A 1zzuA-3otxA:
undetectable		 1zzuA-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 0.95A 1zzuB-3otxA:
undetectable		 1zzuB-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.22A 2c49A-3otxA:
28.7		 2c49A-3otxA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ASP A  17
GLY A  62
GLY A  63
ASN A  67
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
 0.49A 2c49B-3otxA:
27.3		 2c49B-3otxA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.14A 2pkkA-3otxA:
27.8		 2pkkA-3otxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A 299
PHE A 169
ALA A 136
GLY A  62
ASP A  17
 AP5  A 346 ( 3.2A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.6A)
AP5  A 346 (-2.8A)
 1.01A 2pkkA-3otxA:
27.8		 2pkkA-3otxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.14A 2pkmA-3otxA:
27.4		 2pkmA-3otxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ARG A 259
GLU A 225
SER A 249
 None
 0.78A 2xkkA-3otxA:
undetectable
2xkkC-3otxA:
undetectable		 2xkkA-3otxA:
19.97
2xkkC-3otxA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 VAL A  84
VAL A  60
SER A  19
ASN A 295
ASN A  67
 None
None
None
None
AP5  A 346 (-3.4A)
 1.40A 2y00A-3otxA:
undetectable		 2y00A-3otxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 LEU A  39
LEU A  32
ALA A 136
ALA A 198
GLY A  35
ILE A  47
 None
None
AP5  A 346 (-3.5A)
None
None
None
 1.19A 3c6gA-3otxA:
undetectable		 3c6gA-3otxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 GLY A 296
VAL A 329
GLY A 322
THR A 321
 AP5  A 346 (-3.2A)
None
None
None
 0.80A 3ib2A-3otxA:
undetectable		 3ib2A-3otxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 SER A 197
LEU A 213
LEU A 171
ILE A 219
SER A 167
 None
 1.33A 3iltB-3otxA:
undetectable
3iltE-3otxA:
undetectable		 3iltB-3otxA:
20.34
3iltE-3otxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ILE A 219
SER A 167
SER A 197
LEU A 213
LEU A 171
 None
 1.36A 3iltB-3otxA:
undetectable
3iltE-3otxA:
undetectable		 3iltB-3otxA:
20.34
3iltE-3otxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 167
ASN A  13
ASN A 195
ASP A 299
 None
AP5  A 346 (-4.1A)
None
AP5  A 346 ( 3.2A)
 1.04A 3n62B-3otxA:
undetectable		 3n62B-3otxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
SER A  64
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
NA  A 347 (-4.8A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.32A 3uboA-3otxA:
38.2		 3uboA-3otxA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.54A 3uboB-3otxA:
39.5		 3uboB-3otxA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A  17
GLY A  63
ASN A  67
LEU A  39
ASP A 299
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 1.07A 3uboB-3otxA:
39.5		 3uboB-3otxA:
28.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.36A 3uq6A-3otxA:
45.5		 3uq6A-3otxA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.38A 3uq6B-3otxA:
44.0		 3uq6B-3otxA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.41A 3vaqA-3otxA:
45.2		 3vaqA-3otxA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.44A 3vaqB-3otxA:
44.4		 3vaqB-3otxA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.35A 3vasA-3otxA:
45.4		 3vasA-3otxA:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.38A 3vasB-3otxA:
43.9		 3vasB-3otxA:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.43A 4dc3A-3otxA:
43.6		 4dc3A-3otxA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
LEU A  39
ASN A  67
LEU A 138
GLY A 298
ASP A 299
 AP5  A 346 (-4.1A)
None
AP5  A 346 (-3.4A)
None
AP5  A 346 (-3.2A)
AP5  A 346 ( 3.2A)
 1.38A 4dc3A-3otxA:
43.6		 4dc3A-3otxA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.42A 4dc3B-3otxA:
45.5		 4dc3B-3otxA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
LEU A  39
ASN A  67
LEU A 138
GLY A 298
ASP A 299
 AP5  A 346 (-4.1A)
None
AP5  A 346 (-3.4A)
None
AP5  A 346 (-3.2A)
AP5  A 346 ( 3.2A)
 1.42A 4dc3B-3otxA:
45.5		 4dc3B-3otxA:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.43A 4e3aA-3otxA:
39.6		 4e3aA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.43A 4e3aB-3otxA:
39.6		 4e3aB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4jksA-3otxA:
39.6		 4jksA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4jksB-3otxA:
39.6		 4jksB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4jkuA-3otxA:
39.7		 4jkuA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.46A 4jkuB-3otxA:
39.6		 4jkuB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4k8cA-3otxA:
39.5		 4k8cA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4k8cB-3otxA:
39.5		 4k8cB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.28A 4k8kA-3otxA:
39.5		 4k8kA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4k8kB-3otxA:
39.5		 4k8kB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4k8pA-3otxA:
39.6		 4k8pA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4k8pB-3otxA:
39.6		 4k8pB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4k8tA-3otxA:
39.5		 4k8tA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4k8tB-3otxA:
39.5		 4k8tB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.43A 4k93A-3otxA:
39.6		 4k93A-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.42A 4k93B-3otxA:
39.6		 4k93B-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.47A 4k9cA-3otxA:
39.6		 4k9cA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4k9cB-3otxA:
39.7		 4k9cB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.43A 4k9iA-3otxA:
39.6		 4k9iA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4k9iB-3otxA:
39.5		 4k9iB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4kadA-3otxA:
39.5		 4kadA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.47A 4kadB-3otxA:
39.7		 4kadB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.26A 4kahA-3otxA:
39.6		 4kahA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.26A 4kahB-3otxA:
39.5		 4kahB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4kalA-3otxA:
39.5		 4kalA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.28A 4kalB-3otxA:
39.6		 4kalB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4kanA-3otxA:
39.6		 4kanA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4kanB-3otxA:
39.6		 4kanB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4kbeA-3otxA:
39.7		 4kbeA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4kbeB-3otxA:
39.6		 4kbeB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.28A 4lbgA-3otxA:
39.5		 4lbgA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 THR A 264
VAL A 291
ALA A 297
ALA A 326
ILE A 330
 AP5  A 346 (-3.6A)
AP5  A 346 ( 4.9A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
 0.44A 4lbgA-3otxA:
39.5		 4lbgA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4lbgB-3otxA:
39.6		 4lbgB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 THR A 264
VAL A 291
ALA A 297
ALA A 326
ILE A 330
 AP5  A 346 (-3.6A)
AP5  A 346 ( 4.9A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
 0.49A 4lbgB-3otxA:
39.6		 4lbgB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.44A 4lbxA-3otxA:
39.6		 4lbxA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.45A 4lbxB-3otxA:
39.6		 4lbxB-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.46A 4lc4A-3otxA:
39.5		 4lc4A-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
LEU A 138
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 ( 3.2A)
 0.46A 4lc4B-3otxA:
39.6		 4lc4B-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.27A 4lcaA-3otxA:
39.6		 4lcaA-3otxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASN A  13
ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.26A 4lcaB-3otxA:
39.7		 4lcaB-3otxA:
25.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A  17
LEU A  39
CYH A 123
ALA A 136
ASN A  67
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
 1.21A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ASP A  17
LEU A  39
CYH A 123
ALA A 136
PHE A 169
GLY A 296
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
 0.71A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		10 / 12 CYH A  12
ASN A  13
ASP A  17
LEU A  39
GLY A  63
ASN A  67
CYH A 123
ALA A 136
PHE A 169
ASP A 299
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.18A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 CYH A  12
ASN A  13
LEU A  39
ASN A  67
PHE A 169
GLY A 298
ASP A 299
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
None
AP5  A 346 (-3.4A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 ( 3.2A)
 1.15A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 LEU A  15
SER A  64
LEU A 134
LEU A 138
 AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
None
 0.22A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 ASP A  17
LEU A  39
GLY A  62
GLY A  63
CYH A 123
ALA A 136
PHE A 169
GLY A 296
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
 0.64A 4n09B-3otxA:
58.2		 4n09B-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		11 / 12 CYH A  12
ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ALA A 136
PHE A 169
ASP A 299
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.19A 4n09B-3otxA:
58.2		 4n09B-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 CYH A  12
ASN A  13
LEU A  39
GLY A  63
ASN A  67
PHE A 169
GLY A 298
ASP A 299
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
None
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 ( 3.2A)
 1.06A 4n09B-3otxA:
58.2		 4n09B-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 LEU A  15
SER A  64
LEU A 134
LEU A 138
 AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
None
 0.22A 4n09B-3otxA:
58.2		 4n09B-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		9 / 12 ASP A  17
LEU A  39
GLY A  62
GLY A  63
CYH A 123
ALA A 136
LEU A 138
PHE A 169
GLY A 296
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
None
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
 0.64A 4n09C-3otxA:
58.3		 4n09C-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		11 / 12 CYH A  12
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ALA A 136
LEU A 138
PHE A 169
ASP A 299
 AP5  A 346 (-3.6A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
None
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.20A 4n09C-3otxA:
58.3		 4n09C-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 CYH A  12
LEU A  39
GLY A  63
ASN A  67
LEU A 138
PHE A 169
GLY A 298
ASP A 299
 AP5  A 346 (-3.6A)
None
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
None
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 ( 3.2A)
 1.09A 4n09C-3otxA:
58.3		 4n09C-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ASN A  13
LEU A  15
SER A  64
LEU A 134
 AP5  A 346 (-4.1A)
AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
 0.20A 4n09C-3otxA:
58.3		 4n09C-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		10 / 12 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ALA A 136
PHE A 169
ASP A 299
 AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.18A 4n09D-3otxA:
58.3		 4n09D-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASN A  13
LEU A  39
GLY A  63
ASN A  67
PHE A 169
GLY A 298
ASP A 299
 AP5  A 346 (-4.1A)
None
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 ( 3.2A)
 1.06A 4n09D-3otxA:
58.3		 4n09D-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 12 ASP A  17
LEU A  39
GLY A  62
GLY A  63
CYH A 123
ALA A 136
GLY A 296
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.2A)
 0.64A 4n09D-3otxA:
58.3		 4n09D-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 5 CYH A  12
LEU A  15
SER A  64
LEU A 134
LEU A 138
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
None
 0.26A 4n09D-3otxA:
58.3		 4n09D-3otxA:
99.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A  17
GLY A  62
GLY A  63
ASN A  67
ASP A 299
 AP5  A 346 (-2.8A)
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.16A 4ubeA-3otxA:
27.7		 4ubeA-3otxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 LEU A  66
GLU A 106
GLY A  62
PRO A  61
VAL A  60
 None
None
AP5  A 346 (-3.6A)
None
None
 1.25A 5jo9A-3otxA:
7.6		 5jo9A-3otxA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		10 / 12 ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ALA A 136
LEU A 138
PHE A 169
ASP A 299
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
None
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.24A 5kb5A-3otxA:
50.2		 5kb5A-3otxA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 ASN A  13
LEU A  15
SER A  64
LEU A 134
 AP5  A 346 (-4.1A)
AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
 0.23A 5kb5A-3otxA:
50.2		 5kb5A-3otxA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		9 / 12 THR A 264
THR A 270
VAL A 283
GLN A 288
ALA A 297
GLY A 298
HIS A 323
ALA A 326
ILE A 330
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.5A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 (-3.8A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
 0.51A 5kb6A-3otxA:
44.6		 5kb6A-3otxA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 12 THR A 264
VAL A 283
GLN A 288
ALA A 297
GLY A 298
HIS A 323
ALA A 326
ILE A 330
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 (-3.8A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.9A)
 0.54A 5kb6B-3otxA:
44.8		 5kb6B-3otxA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ARG A  70
ARG A  58
ARG A 332
 None
 0.90A 6bplA-3otxA:
undetectable
6bplB-3otxA:
undetectable		 6bplA-3otxA:
12.06
6bplB-3otxA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 VAL A  68
TYR A 165
ASN A  13
CYH A 123
 None
None
AP5  A 346 (-4.1A)
AP5  A 346 (-3.7A)
 1.24A 6gneB-3otxA:
6.2		 6gneB-3otxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 TRP A 235
ILE A 243
GLU A 228
 None
 0.72A 6hcxA-3otxA:
undetectable		 6hcxA-3otxA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3otx ADENOSINE KINASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 11 ASN A 142
LEU A 138
LEU A 171
GLY A 168
PHE A 166
 None
 1.36A 6r2eG-3otxA:
undetectable		 6r2eG-3otxA:
22.02