SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ou6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 TRP A 102
ALA A 127
VAL A 132
None
0.97A 1bdwA-3ou6A:
undetectable
1bdwB-3ou6A:
undetectable
1bdwA-3ou6A:
7.81
1bdwB-3ou6A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 5 LEU A  64
GLY A 140
ALA A  68
ILE A  46
None
0.84A 2aohB-3ou6A:
undetectable
2aohB-3ou6A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 7 TYR A  22
GLY A  56
ASP A  75
ASP A  98
SAM  A 300 (-4.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
0.55A 2g72B-3ou6A:
17.2
2g72B-3ou6A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
5 / 10 ALA A  82
ALA A  84
THR A  61
LEU A  89
VAL A  92
None
1.38A 2wuzA-3ou6A:
undetectable
2wuzA-3ou6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
5 / 10 ALA A  82
ALA A  84
THR A  61
LEU A  89
VAL A  92
None
1.38A 2wuzB-3ou6A:
undetectable
2wuzB-3ou6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 5 TYR A  22
GLU A  52
ASP A  75
ASP A  98
SAM  A 300 (-4.4A)
None
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
0.86A 2yqzA-3ou6A:
16.1
2yqzA-3ou6A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 5 TYR A  22
GLU A  52
ASP A  75
ASP A  98
SAM  A 300 (-4.4A)
None
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
0.86A 2yqzB-3ou6A:
16.3
2yqzB-3ou6A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 GLY A  56
ASP A  75
SER A  77
SAM  A 300 (-3.1A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.5A)
0.67A 3brfA-3ou6A:
undetectable
3brfA-3ou6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
5 / 12 LEU A  12
TYR A  15
GLY A  56
GLY A  76
SER A  77
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
0.77A 3e23A-3ou6A:
19.0
3e23A-3ou6A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 ASP A  23
PHE A  26
SER A  55
None
1.00A 3i5uB-3ou6A:
14.4
3i5uB-3ou6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 TRP A 102
ALA A 127
VAL A 132
None
0.89A 3l8lA-3ou6A:
undetectable
3l8lB-3ou6A:
undetectable
3l8lA-3ou6A:
7.81
3l8lB-3ou6A:
6.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  15
ALA A  54
GLY A  56
TRP A  60
GLY A  76
SER A  77
MET A  80
ASP A  98
LEU A  99
ALA A 114
TRP A 116
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.6A)
None
0.02A 3ou6A-3ou6A:
41.7
3ou6A-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  15
ALA A  54
GLY A  56
TRP A  60
GLY A  76
SER A  77
MET A  80
LEU A  99
ALA A 114
TRP A 116
HIS A 119
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.6A)
None
SO4  A 301 (-4.0A)
0.10A 3ou6B-3ou6A:
39.1
3ou6B-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 TYR A  22
ASP A  75
ASP A  98
SAM  A 300 (-4.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
0.14A 3ou6B-3ou6A:
39.1
3ou6B-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  15
GLU A  52
ALA A  54
TRP A  60
GLY A  76
SER A  77
MET A  80
ASP A  98
LEU A  99
ALA A 114
TRP A 116
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
None
SAM  A 300 (-3.4A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.6A)
None
0.12A 3ou6C-3ou6A:
38.1
3ou6C-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 TYR A  22
GLY A  56
ASP A  75
SAM  A 300 (-4.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-2.8A)
0.04A 3ou6C-3ou6A:
38.1
3ou6C-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  15
TYR A  22
GLU A  52
ALA A  54
TRP A  60
GLY A  76
SER A  77
MET A  80
ASP A  98
LEU A  99
TRP A 116
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-4.4A)
None
SAM  A 300 (-3.4A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
None
0.19A 3ou6D-3ou6A:
39.5
3ou6D-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  15
TYR A  22
ALA A  54
GLY A  56
TRP A  60
GLY A  76
SER A  77
MET A  80
ASP A  98
LEU A  99
TRP A 116
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-4.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
None
0.12A 3ou7A-3ou6A:
40.0
3ou7A-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  22
ALA A  54
GLY A  56
TRP A  60
GLY A  76
SER A  77
MET A  80
LEU A  99
ALA A 114
TRP A 116
HIS A 119
SAM  A 300 ( 3.9A)
SAM  A 300 (-4.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.6A)
None
SO4  A 301 (-4.0A)
0.16A 3ou7B-3ou6A:
38.6
3ou7B-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 TYR A  15
ASP A  75
ASP A  98
SAM  A 300 ( 3.5A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
0.06A 3ou7B-3ou6A:
38.6
3ou7B-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  15
TYR A  22
ALA A  54
TRP A  60
GLY A  76
SER A  77
MET A  80
LEU A  99
ALA A 114
TRP A 116
HIS A 119
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-4.4A)
SAM  A 300 (-3.4A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.6A)
None
SO4  A 301 (-4.0A)
0.13A 3ou7C-3ou6A:
39.2
3ou7C-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 GLY A  56
ASP A  75
ASP A  98
SAM  A 300 (-3.1A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
0.10A 3ou7C-3ou6A:
39.2
3ou7C-3ou6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
12 / 12 LEU A  12
TYR A  15
TYR A  22
ALA A  54
GLY A  56
TRP A  60
GLY A  76
SER A  77
MET A  80
ASP A  98
LEU A  99
TRP A 116
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-4.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
None
0.12A 3ou7D-3ou6A:
39.6
3ou7D-3ou6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
5 / 12 TYR A  15
ALA A  54
GLY A  56
MET A  80
HIS A 119
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.0A)
SO4  A 301 (-4.0A)
0.98A 3pfgA-3ou6A:
14.4
3pfgA-3ou6A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
6 / 12 TYR A  15
ALA A  54
GLY A  56
SER A  77
MET A  80
ASP A  98
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
0.96A 3pfgA-3ou6A:
14.4
3pfgA-3ou6A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 ASP A  23
GLY A  58
TYR A  22
None
None
SAM  A 300 (-4.4A)
0.66A 3w9tC-3ou6A:
undetectable
3w9tC-3ou6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 ASP A  23
GLY A  58
TYR A  22
None
None
SAM  A 300 (-4.4A)
0.66A 3w9tG-3ou6A:
undetectable
3w9tG-3ou6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 7 VAL A 181
PRO A 121
TYR A  14
TYR A  15
None
None
None
SAM  A 300 ( 3.5A)
0.80A 4lb2A-3ou6A:
undetectable
4lb2A-3ou6A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 5 GLY A  58
THR A  61
HIS A  87
GLY A  85
None
1.09A 4v20A-3ou6A:
undetectable
4v20A-3ou6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 7 ASN A  91
VAL A  71
ALA A  73
GLY A  58
None
0.80A 5fpdA-3ou6A:
undetectable
5fpdA-3ou6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
4 / 7 ASN A  91
VAL A  71
ALA A  73
GLY A  58
None
0.81A 5fpdB-3ou6A:
undetectable
5fpdB-3ou6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
6 / 12 ALA A  54
GLY A  56
GLY A  76
SER A  77
MET A  80
HIS A 119
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SO4  A 301 (-4.0A)
0.79A 5gwxA-3ou6A:
16.1
5gwxA-3ou6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
6 / 12 GLY A  56
GLY A  76
SER A  77
MET A  80
ASP A  98
HIS A 119
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
SO4  A 301 (-4.0A)
0.57A 5hikA-3ou6A:
17.8
5hikA-3ou6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus)
3 / 3 HIS A 119
ARG A 168
ILE A 178
SO4  A 301 (-4.0A)
SO4  A 301 (-2.8A)
None
0.77A 6fgdA-3ou6A:
undetectable
6fgdA-3ou6A:
19.57