SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ouh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 5 ARG A 383
MET A 299
ASN A 316
TYR A 303
 014  A 417 (-3.1A)
014  A 417 (-3.4A)
None
None
 1.40A 1nbiA-3ouhA:
0.0		 1nbiA-3ouhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 5 ARG A 383
MET A 299
ASN A 316
TYR A 303
 014  A 417 (-3.1A)
014  A 417 (-3.4A)
None
None
 1.41A 1nbiB-3ouhA:
0.0		 1nbiB-3ouhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.06A 1oniA-3ouhA:
undetectable
1oniB-3ouhA:
undetectable		 1oniA-3ouhA:
20.00
1oniB-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 PHE A 360
ASN A 331
ILE A 222
GLY A 223
 None
 0.87A 1oniA-3ouhA:
undetectable
1oniB-3ouhA:
undetectable		 1oniA-3ouhA:
20.00
1oniB-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.01A 1oniB-3ouhA:
undetectable
1oniC-3ouhA:
undetectable		 1oniB-3ouhA:
20.00
1oniC-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 PHE A 360
ASN A 331
ILE A 222
GLY A 223
 None
 0.83A 1oniD-3ouhA:
undetectable
1oniF-3ouhA:
undetectable		 1oniD-3ouhA:
20.00
1oniF-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 TYR A 303
ILE A 256
ARG A 383
ALA A 385
 None
None
014  A 417 (-3.1A)
014  A 417 ( 3.9A)
 1.06A 1oniD-3ouhA:
undetectable
1oniE-3ouhA:
undetectable		 1oniD-3ouhA:
20.00
1oniE-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.07A 1oniH-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniH-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 TYR A 303
ILE A 256
ARG A 383
ALA A 385
 None
None
014  A 417 (-3.1A)
014  A 417 ( 3.9A)
 1.00A 1oniG-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniG-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 ILE A 222
GLY A 223
PHE A 360
ASN A 331
 None
 0.65A 1oniG-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniG-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 HIS A 230
THR A 382
TYR A 384
LEU A 330
 None
 1.10A 1qzrA-3ouhA:
undetectable		 1qzrA-3ouhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 HIS A 230
THR A 382
TYR A 384
LEU A 330
 None
 1.09A 1qzrB-3ouhA:
undetectable		 1qzrB-3ouhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 11 HIS A 313
ASP A 315
THR A 325
HIS A 374
VAL A 376
 FE2  A 600 ( 3.2A)
FE2  A 600 ( 2.5A)
None
FE2  A 600 ( 3.2A)
014  A 417 (-4.8A)
 0.56A 1uofA-3ouhA:
10.4		 1uofA-3ouhA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 4 TYR A 303
ARG A 383
ASP A 315
ASP A 369
 None
014  A 417 (-3.1A)
FE2  A 600 ( 2.5A)
None
 1.28A 1ve3A-3ouhA:
0.3		 1ve3A-3ouhA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 4 TYR A 303
ARG A 383
ASP A 315
ASP A 369
 None
014  A 417 (-3.1A)
FE2  A 600 ( 2.5A)
None
 1.31A 1ve3B-3ouhA:
0.0		 1ve3B-3ouhA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 GLY A 261
SER A 274
ILE A 259
GLU A 260
 None
 0.82A 3a7eA-3ouhA:
undetectable		 3a7eA-3ouhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 TYR A 303
HIS A 313
HIS A 374
TYR A 329
 None
FE2  A 600 ( 3.2A)
FE2  A 600 ( 3.2A)
014  A 417 (-4.7A)
 1.38A 4df2A-3ouhA:
undetectable		 4df2A-3ouhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 10 TYR A 329
ASN A 331
VAL A 376
GLY A 340
ALA A 336
 014  A 417 (-4.7A)
None
014  A 417 (-4.8A)
None
None
 1.14A 4fh2A-3ouhA:
undetectable		 4fh2A-3ouhA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 12 GLY A 238
ASP A 237
ILE A 256
ALA A 301
PHE A 235
 None
 1.34A 4wh5A-3ouhA:
undetectable		 4wh5A-3ouhA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 271
THR A 257
ALA A 298
LYS A 297
ILE A 386
 None
 1.10A 4x1iD-3ouhA:
undetectable		 4x1iD-3ouhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 271
THR A 257
ALA A 298
LYS A 297
ILE A 386
 None
 1.11A 4x1yB-3ouhA:
undetectable		 4x1yB-3ouhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 271
THR A 257
ALA A 298
LYS A 297
ILE A 386
 None
 1.10A 5mioB-3ouhA:
undetectable		 5mioB-3ouhA:
18.83