SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ouk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 168
LEU A 103
LEU A  31
ILE A  24
PHE A  34
 None
 1.40A 1fmlA-3oukA:
undetectable		 1fmlA-3oukA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 4 VAL A  55
TRP A  44
TRP A 108
 None
 1.38A 1gmkC-3oukA:
undetectable
1gmkD-3oukA:
undetectable		 1gmkC-3oukA:
6.96
1gmkD-3oukA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  81
GLY A 145
ALA A 144
VAL A  89
ILE A  84
 None
 0.89A 2o4lB-3oukA:
undetectable		 2o4lB-3oukA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 164
ALA A 135
THR A 260
ILE A 232
LEU A 192
 None
 1.00A 2oipA-3oukA:
undetectable		 2oipA-3oukA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  81
GLY A 145
ALA A 144
VAL A  89
ILE A  84
 None
 0.93A 2q63B-3oukA:
undetectable		 2q63B-3oukA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  81
GLY A 145
ALA A 144
VAL A  89
ILE A  84
 None
 0.84A 2q64B-3oukA:
undetectable		 2q64B-3oukA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 259
THR A 260
ALA A 263
ARG A 129
 None
 0.79A 2ql8A-3oukA:
undetectable
2ql8B-3oukA:
undetectable		 2ql8A-3oukA:
18.35
2ql8B-3oukA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  81
GLY A 145
ALA A 144
VAL A  89
ILE A  84
 None
 0.89A 3em3A-3oukA:
undetectable		 3em3A-3oukA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 164
ALA A 135
THR A 260
ILE A 232
LEU A 192
 None
 0.97A 3hj3D-3oukA:
undetectable		 3hj3D-3oukA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  81
GLY A 145
ALA A 144
VAL A  89
ILE A  84
 None
 0.86A 3k4vB-3oukA:
undetectable		 3k4vB-3oukA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  81
GLY A 145
ALA A 144
VAL A  89
ILE A  84
 None
 0.90A 3oxvA-3oukA:
undetectable		 3oxvA-3oukA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 163
VAL A 156
VAL A 117
SER A 159
GLY A 112
 None
 1.21A 4mm6A-3oukA:
undetectable		 4mm6A-3oukA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 202
HIS A 152
GLY A  36
GLU A 200
 None
 0.88A 4v20A-3oukA:
undetectable		 4v20A-3oukA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 164
LEU A 252
ILE A 184
LEU A 134
ILE A 150
 None
 0.94A 4y0rA-3oukA:
undetectable		 4y0rA-3oukA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 THR A  74
LEU A  75
LEU A  71
THR A  58
 None
 0.70A 4z90A-3oukA:
2.1
4z90B-3oukA:
2.0
4z90C-3oukA:
undetectable
4z90D-3oukA:
undetectable
4z90E-3oukA:
undetectable		 4z90A-3oukA:
20.90
4z90B-3oukA:
20.90
4z90C-3oukA:
20.90
4z90D-3oukA:
20.90
4z90E-3oukA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  71
THR A  58
THR A  74
LEU A  75
 None
 0.67A 4z90F-3oukA:
undetectable
4z90G-3oukA:
undetectable
4z90H-3oukA:
undetectable
4z90I-3oukA:
undetectable
4z90J-3oukA:
undetectable		 4z90F-3oukA:
20.90
4z90G-3oukA:
20.90
4z90H-3oukA:
20.90
4z90I-3oukA:
20.90
4z90J-3oukA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 THR A  58
THR A  74
LEU A  75
LEU A  71
 None
 0.69A 4z90F-3oukA:
undetectable
4z90G-3oukA:
undetectable
4z90H-3oukA:
undetectable
4z90I-3oukA:
undetectable
4z90J-3oukA:
undetectable		 4z90F-3oukA:
20.90
4z90G-3oukA:
20.90
4z90H-3oukA:
20.90
4z90I-3oukA:
20.90
4z90J-3oukA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 186
SER A 187
SER A 205
PRO A 199
 None
 1.21A 5c6pA-3oukA:
undetectable		 5c6pA-3oukA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 130
MET A 256
LEU A 191
LEU A 192
 None
 1.05A 5dzkF-3oukA:
undetectable
5dzkT-3oukA:
undetectable		 5dzkF-3oukA:
23.02
5dzkT-3oukA:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 184
ALA A 249
LEU A 252
ILE A 246
 None
 0.87A 5mvmB-3oukA:
undetectable
5mvmC-3oukA:
undetectable		 5mvmB-3oukA:
17.51
5mvmC-3oukA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 MET A 256
ALA A 236
SER A 239
LEU A 252
ASP A 179
 None
 1.49A 5vlmA-3oukA:
undetectable		 5vlmA-3oukA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  81
GLY A 145
ALA A 144
VAL A  89
ILE A  84
 None
 0.87A 6difB-3oukA:
undetectable		 6difB-3oukA:
15.09