SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3out'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 11 HIS A 185
THR A 119
THR A 116
GLY A 182
THR A 184
 DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
None
DGL  A 266 (-3.3A)
 1.02A 1c9sP-3outA:
undetectable
1c9sQ-3outA:
undetectable		 1c9sP-3outA:
12.83
1c9sQ-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 1gtfJ-3outA:
undetectable
1gtfK-3outA:
undetectable		 1gtfJ-3outA:
12.83
1gtfK-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 11 HIS A 185
THR A 119
THR A 116
GLY A 182
THR A 184
 DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
None
DGL  A 266 (-3.3A)
 1.01A 1gtfQ-3outA:
undetectable
1gtfR-3outA:
undetectable		 1gtfQ-3outA:
12.83
1gtfR-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 11 HIS A 185
THR A 119
THR A 116
GLY A 182
THR A 184
 DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
None
DGL  A 266 (-3.3A)
 1.04A 1gtfS-3outA:
undetectable
1gtfT-3outA:
undetectable		 1gtfS-3outA:
12.83
1gtfT-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 11 HIS A 185
THR A 119
THR A 116
GLY A 182
THR A 184
 DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
None
DGL  A 266 (-3.3A)
 1.05A 1gtnT-3outA:
undetectable
1gtnU-3outA:
undetectable		 1gtnT-3outA:
12.83
1gtnU-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		4 / 6 TYR A 186
VAL A  97
ILE A  98
LEU A 179
 None
 1.11A 1j96A-3outA:
undetectable		 1j96A-3outA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 HIS A 185
THR A 119
THR A 116
GLY A 182
THR A 184
 DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
None
DGL  A 266 (-3.3A)
 1.05A 1utdE-3outA:
undetectable
1utdF-3outA:
undetectable		 1utdE-3outA:
12.83
1utdF-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 HIS A 185
THR A 119
THR A 116
GLY A 182
THR A 184
 DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
None
DGL  A 266 (-3.3A)
 1.05A 1utdH-3outA:
undetectable
1utdI-3outA:
undetectable		 1utdH-3outA:
12.83
1utdI-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 11 HIS A 185
THR A 119
THR A 116
GLY A 182
THR A 184
 DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
None
DGL  A 266 (-3.3A)
 1.03A 1utdS-3outA:
undetectable
1utdT-3outA:
undetectable		 1utdS-3outA:
12.83
1utdT-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 11 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.06A 1utdL-3outA:
undetectable
1utdV-3outA:
undetectable		 1utdL-3outA:
12.83
1utdV-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 LEU A  17
PHE A  10
GLY A   8
ILE A  63
VAL A  85
 None
 1.22A 2zznA-3outA:
2.1		 2zznA-3outA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 TYR A  34
ILE A  14
GLY A  36
LEU A 257
LEU A 250
 None
 1.07A 3em0B-3outA:
undetectable		 3em0B-3outA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 7 TYR A 170
LEU A 168
LEU A 179
SER A 140
ASN A 141
 None
 1.27A 3lm8B-3outA:
3.2
3lm8D-3outA:
3.3		 3lm8B-3outA:
23.57
3lm8D-3outA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 8 TYR A 170
LEU A 168
LEU A 179
SER A 140
ASN A 141
 None
 1.36A 3lm8A-3outA:
3.6
3lm8C-3outA:
2.7		 3lm8A-3outA:
23.57
3lm8C-3outA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 LEU A 216
ASN A 219
ALA A  69
ILE A  71
ILE A   7
 None
 1.01A 3ut5B-3outA:
undetectable		 3ut5B-3outA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 SER A  12
CYH A  74
PRO A  42
ALA A 118
GLY A 144
 DGL  A 266 (-2.8A)
DGL  A 266 ( 3.7A)
DGL  A 266 (-4.5A)
None
None
 0.96A 4j7xA-3outA:
undetectable		 4j7xA-3outA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 SER A  12
CYH A  74
PRO A  42
ALA A 118
GLY A 144
 DGL  A 266 (-2.8A)
DGL  A 266 ( 3.7A)
DGL  A 266 (-4.5A)
None
None
 0.98A 4j7xB-3outA:
undetectable		 4j7xB-3outA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		4 / 8 LEU A 222
PRO A  93
VAL A   9
GLY A   8
 None
 0.81A 4klrB-3outA:
4.9		 4klrB-3outA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 LEU A  23
LEU A  27
ILE A   7
ASN A 219
SER A 209
 None
 0.83A 4lmnA-3outA:
undetectable		 4lmnA-3outA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 LEU A 216
ASN A 219
ALA A  69
ILE A  71
ILE A   7
 None
 1.06A 4o2bB-3outA:
undetectable		 4o2bB-3outA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 5eevA-3outA:
undetectable
5eevB-3outA:
undetectable		 5eevA-3outA:
12.83
5eevB-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.09A 5eewA-3outA:
undetectable
5eewB-3outA:
undetectable		 5eewA-3outA:
12.83
5eewB-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.09A 5eexA-3outA:
undetectable
5eexB-3outA:
undetectable		 5eexA-3outA:
12.83
5eexB-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 5eeyA-3outA:
undetectable
5eeyB-3outA:
undetectable		 5eeyA-3outA:
12.83
5eeyB-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 5eezA-3outA:
undetectable
5eezB-3outA:
undetectable		 5eezA-3outA:
12.83
5eezB-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 5ef0A-3outA:
undetectable
5ef0B-3outA:
undetectable		 5ef0A-3outA:
12.83
5ef0B-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 5ef1A-3outA:
undetectable
5ef1B-3outA:
undetectable		 5ef1A-3outA:
12.83
5ef1B-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 5ef2A-3outA:
undetectable
5ef2B-3outA:
undetectable		 5ef2A-3outA:
12.83
5ef2B-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 10 GLY A 182
THR A 184
HIS A 185
THR A 119
THR A 116
 None
DGL  A 266 (-3.3A)
DGL  A 266 ( 4.8A)
None
DGL  A 266 ( 3.8A)
 1.08A 5ef3A-3outA:
undetectable
5ef3B-3outA:
undetectable		 5ef3A-3outA:
12.83
5ef3B-3outA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		4 / 6 GLY A 246
GLU A 247
PHE A 249
TYR A  34
 None
 0.95A 5kmfA-3outA:
undetectable
5kmfC-3outA:
undetectable		 5kmfA-3outA:
23.00
5kmfC-3outA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		4 / 8 THR A  18
SER A 209
ASP A  96
SER A  78
 None
 1.11A 5l5fY-3outA:
undetectable
5l5fZ-3outA:
undetectable		 5l5fY-3outA:
21.05
5l5fZ-3outA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 LEU A 216
ASN A 219
ALA A  69
ILE A  71
ILE A   7
 None
 1.04A 5mioB-3outA:
undetectable		 5mioB-3outA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3out GLUTAMATE RACEMASE
(Francisella
tularensis) 		5 / 12 GLY A  13
GLY A  36
VAL A  20
GLY A  16
GLY A  15
 DGL  A 266 (-4.6A)
None
None
None
None
 0.88A 5zhmB-3outA:
4.3		 5zhmB-3outA:
24.00