SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ov3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ALA A  17
ILE A 236
 None
 0.88A 1epbA-3ov3A:
undetectable		 1epbA-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.02A 1epbA-3ov3A:
undetectable		 1epbA-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ALA A  17
ILE A 236
 None
 0.93A 1epbB-3ov3A:
undetectable		 1epbB-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.94A 1epbB-3ov3A:
undetectable		 1epbB-3ov3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.33A 1fkoA-3ov3A:
undetectable		 1fkoA-3ov3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 11 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.34A 1fkpA-3ov3A:
undetectable		 1fkpA-3ov3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 11 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.23A 1jkhA-3ov3A:
undetectable
1jkhB-3ov3A:
undetectable		 1jkhA-3ov3A:
19.86
1jkhB-3ov3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 11 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.31A 1lwcA-3ov3A:
undetectable		 1lwcA-3ov3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 9 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.39A 1lwfA-3ov3A:
undetectable		 1lwfA-3ov3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 ALA A 113
GLU A 116
MET A  20
ARG A 350
LEU A 187
 None
 1.41A 1qkuA-3ov3A:
undetectable		 1qkuA-3ov3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 ALA A 113
GLU A 116
MET A  20
ARG A 350
LEU A 187
 None
 1.40A 1qkuB-3ov3A:
undetectable		 1qkuB-3ov3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 ALA A 113
GLU A 116
MET A  20
ARG A 350
LEU A 187
 None
 1.42A 1qkuC-3ov3A:
undetectable		 1qkuC-3ov3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 9 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.35A 1vrtA-3ov3A:
undetectable		 1vrtA-3ov3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 9 GLY A 376
SER A 378
LEU A 377
LEU A 271
HIS A 165
 None
 1.29A 1y7iA-3ov3A:
undetectable		 1y7iA-3ov3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.31A 2hndA-3ov3A:
undetectable		 2hndA-3ov3A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.29A 2hnyA-3ov3A:
undetectable		 2hnyA-3ov3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		3 / 3 SER A  34
GLN A  33
PHE A  36
 None
 0.64A 3g4lC-3ov3A:
undetectable		 3g4lC-3ov3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		3 / 3 ILE A 132
PHE A 215
HIS A 165
 MLI  A 396 (-2.9A)
None
None
 0.75A 3h0aA-3ov3A:
undetectable		 3h0aA-3ov3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 9 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.44A 3lp0A-3ov3A:
undetectable		 3lp0A-3ov3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.27A 3lp1A-3ov3A:
undetectable		 3lp1A-3ov3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 10 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.34A 3qipA-3ov3A:
undetectable		 3qipA-3ov3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 5 SER A 386
THR A 360
GLU A 238
ASP A 227
 None
 1.16A 3tm4A-3ov3A:
2.7		 3tm4A-3ov3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 5 SER A 386
THR A 360
GLU A 238
ASP A 227
 None
 1.18A 3tm4B-3ov3A:
undetectable		 3tm4B-3ov3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 5 VAL A 301
LEU A 370
LEU A 384
ILE A  22
 None
 0.92A 4a9jC-3ov3A:
undetectable		 4a9jC-3ov3A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 8 LEU A 127
SER A 339
VAL A  99
GLY A 134
 None
 1.01A 4klrB-3ov3A:
undetectable		 4klrB-3ov3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		6 / 12 ALA A 163
CYH A 164
SER A 197
PHE A 265
HIS A 303
GLY A 374
 None
None
MLI  A 396 (-3.0A)
None
None
None
 1.37A 4ls7A-3ov3A:
22.5
4ls7B-3ov3A:
22.5		 4ls7A-3ov3A:
22.10
4ls7B-3ov3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 5 LEU A 324
ILE A 309
LEU A 279
LEU A 384
 None
 0.76A 4o8fA-3ov3A:
undetectable		 4o8fA-3ov3A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 11 GLY A 256
GLY A 255
GLY A 262
ILE A 132
PHE A 215
 None
None
None
MLI  A 396 (-2.9A)
None
 1.17A 4qoiA-3ov3A:
undetectable
4qoiB-3ov3A:
undetectable		 4qoiA-3ov3A:
20.54
4qoiB-3ov3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 12 THR A 341
GLN A 338
ALA A 109
ALA A 190
CYH A 130
 None
MLI  A 396 (-3.2A)
None
None
None
 1.43A 5d0xH-3ov3A:
undetectable
5d0xI-3ov3A:
undetectable		 5d0xH-3ov3A:
19.33
5d0xI-3ov3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 12 GLY A 374
ILE A 236
TYR A 237
GLY A  23
HIS A 303
 None
 1.22A 5eslA-3ov3A:
undetectable		 5eslA-3ov3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		3 / 3 ARG A   8
ASN A 181
ASP A 227
 None
 0.87A 5gwxA-3ov3A:
undetectable		 5gwxA-3ov3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 11 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.29A 5hbmA-3ov3A:
undetectable		 5hbmA-3ov3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 8 ARG A 385
GLU A 238
GLY A  15
PRO A  16
 None
 0.93A 5kf8A-3ov3A:
undetectable		 5kf8A-3ov3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 8 GLU A 238
PRO A 228
GLY A  15
PRO A  16
 None
 1.03A 5kf8A-3ov3A:
undetectable		 5kf8A-3ov3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 4 LEU A  70
MET A 337
ILE A  97
LEU A 105
 None
 1.08A 5nfpA-3ov3A:
undetectable		 5nfpA-3ov3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		5 / 9 VAL A 254
ILE A 309
LEU A 271
ILE A 275
ALA A 163
 None
 0.91A 5nunA-3ov3A:
undetectable		 5nunA-3ov3A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		3 / 3 GLU A 179
ASP A 227
PRO A 228
 None
 0.44A 6berA-3ov3A:
undetectable		 6berA-3ov3A:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		6 / 12 LEU A 171
GLY A 225
ALA A  17
ILE A 236
VAL A 382
ILE A 239
 None
 1.27A 6dilB-3ov3A:
undetectable		 6dilB-3ov3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		4 / 4 ASP A 217
ILE A 102
PRO A 103
LEU A 105
 None
 1.12A 6mkeA-3ov3A:
undetectable		 6mkeA-3ov3A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ov3 CURCUMIN SYNTHASE
(Curcuma
longa) 		3 / 3 ARG A  94
PHE A 211
PHE A 261
 None
 1.09A 6nknC-3ov3A:
undetectable
6nknJ-3ov3A:
undetectable		 6nknC-3ov3A:
20.24
6nknJ-3ov3A:
9.67