SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ovz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3ovz CATHEPSIN K
(Homo
sapiens) 		5 / 10 ALA A 104
GLY A 102
GLU A  84
GLU A  35
LEU A  48
 None
 1.32A 1cmcA-3ovzA:
undetectable
1cmcB-3ovzA:
undetectable		 1cmcA-3ovzA:
15.09
1cmcB-3ovzA:
15.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3ovz CATHEPSIN K
(Homo
sapiens) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 163
GLY A  65
 O96  A   1 (-3.0A)
O96  A   1 (-3.0A)
None
None
None
O96  A   1 (-3.4A)
O96  A   1 (-3.0A)
 1.16A 1stfE-3ovzA:
34.3
1stfI-3ovzA:
undetectable		 1stfE-3ovzA:
43.64
1stfI-3ovzA:
16.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3ovz CATHEPSIN K
(Homo
sapiens) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 162
ALA A 163
 O96  A   1 (-3.0A)
O96  A   1 (-3.0A)
None
None
None
None
O96  A   1 (-3.4A)
O96  A   1 (-3.4A)
 0.36A 1stfE-3ovzA:
34.3
1stfI-3ovzA:
undetectable		 1stfE-3ovzA:
43.64
1stfI-3ovzA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3ovz CATHEPSIN K
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 O96  A   1 (-3.0A)
O96  A   1 (-3.0A)
O96  A   1 (-3.4A)
None
 0.49A 3ai8A-3ovzA:
27.7		 3ai8A-3ovzA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ovz CATHEPSIN K
(Homo
sapiens) 		3 / 3 SER A  24
GLY A  20
GLY A  91
 None
 0.55A 3bogA-3ovzA:
undetectable
3bogC-3ovzA:
undetectable		 3bogA-3ovzA:
undetectable
3bogC-3ovzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3ovz CATHEPSIN K
(Homo
sapiens) 		4 / 7 GLN A  76
TYR A 110
PRO A 213
GLN A  37
 None
 1.24A 3l2vA-3ovzA:
undetectable		 3l2vA-3ovzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ovz CATHEPSIN K
(Homo
sapiens) 		3 / 3 PHE A  28
VAL A 167
ILE A 180
 None
 0.56A 4emaA-3ovzA:
undetectable		 4emaA-3ovzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3ovz CATHEPSIN K
(Homo
sapiens) 		5 / 9 LEU A 121
GLY A 168
VAL A 131
SER A 132
VAL A 133
 None
 1.22A 4qd3A-3ovzA:
undetectable		 4qd3A-3ovzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3ovz CATHEPSIN K
(Homo
sapiens) 		5 / 10 THR A  42
LEU A  46
VAL A  31
LEU A  34
MET A 215
 None
 1.38A 4r3aB-3ovzA:
undetectable		 4r3aB-3ovzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3ovz CATHEPSIN K
(Homo
sapiens) 		4 / 8 LYS A  10
GLY A  11
GLY A  43
GLU A  35
 None
 0.71A 6mdqA-3ovzA:
undetectable		 6mdqA-3ovzA:
18.66