SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ow2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		3 / 3 TRP A 186
ARG A  51
THR A 184
 A  01847 ( 4.1A)
U  01874 ( 4.6A)
U  01879 ( 3.1A)
 0.88A 1df7A-3ow2A:
undetectable		 1df7A-3ow2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3ow2 50S RIBOSOMAL
PROTEIN L15P
(Haloarcula
marismortui) 		3 / 3 ASP K 123
ASP K 104
ASP K 144
 None
 0.78A 1eizA-3ow2K:
undetectable		 1eizA-3ow2K:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3ow2 50S RIBOSOMAL
PROTEIN L24P
(Haloarcula
marismortui) 		3 / 3 ARG S 108
GLY S  45
ASP S  46
 None
 0.58A 1kf6A-3ow2S:
undetectable
1kf6B-3ow2S:
undetectable		 1kf6A-3ow2S:
11.90
1kf6B-3ow2S:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		3 / 3 ARG A  30
GLY A  63
ASP A  62
 None
 0.59A 1kf6A-3ow2A:
undetectable
1kf6B-3ow2A:
undetectable		 1kf6A-3ow2A:
17.08
1kf6B-3ow2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3ow2 50S RIBOSOMAL
PROTEIN L15P
(Haloarcula
marismortui) 		5 / 12 GLU K 134
GLY K 138
GLY K 137
VAL K 140
GLY K 110
 None
None
None
None
A  0 698 ( 3.6A)
 0.94A 1n2xB-3ow2K:
undetectable		 1n2xB-3ow2K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3ow2 50S RIBOSOMAL
PROTEIN L24E
(Haloarcula
marismortui) 		5 / 12 CYH T  32
PRO T  15
GLY T  16
ASP T  12
PHE T  31
 CD  T8701 (-2.2A)
None
None
None
None
 1.49A 2b9eA-3ow2T:
undetectable		 2b9eA-3ow2T:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3ow2 50S RIBOSOMAL
PROTEIN L32E
(Haloarcula
marismortui) 		3 / 3 ARG X 175
ASP X 113
ASP X 108
 G  01269 ( 3.6A)
None
None
 0.78A 2ejtA-3ow2X:
undetectable		 2ejtA-3ow2X:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		5 / 9 LEU A  67
ILE A  45
ALA A  70
GLY A  40
LEU A  80
 None
 1.26A 2v0mB-3ow2A:
undetectable		 2v0mB-3ow2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		4 / 6 HIS A 131
LEU A 128
ALA A 154
PRO A  95
 None
 1.16A 3gv1A-3ow2A:
undetectable
3gv1C-3ow2A:
undetectable		 3gv1A-3ow2A:
16.94
3gv1C-3ow2A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		4 / 6 LEU A 128
ALA A 154
PRO A  95
HIS A 131
 None
 1.13A 3gv1A-3ow2A:
undetectable
3gv1B-3ow2A:
undetectable		 3gv1A-3ow2A:
16.94
3gv1B-3ow2A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3ow2 50S RIBOSOMAL
PROTEIN L15P
(Haloarcula
marismortui) 		3 / 3 ARG K  90
ASP K  95
ASP K  80
 None
 0.94A 3jb3A-3ow2K:
undetectable		 3jb3A-3ow2K:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ow2 50S RIBOSOMAL
PROTEIN L19E
(Haloarcula
marismortui) 		5 / 9 LEU O   3
PHE O  23
ILE O  49
ALA O  48
ALA O  34
 C  01396 ( 3.8A)
None
None
None
None
 0.99A 3mdvA-3ow2O:
undetectable		 3mdvA-3ow2O:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ow2 50S RIBOSOMAL
PROTEIN L19E
(Haloarcula
marismortui) 		5 / 12 LEU O   3
PHE O  23
ILE O  49
ALA O  48
ALA O  34
 C  01396 ( 3.8A)
None
None
None
None
 0.98A 3mdvB-3ow2O:
undetectable		 3mdvB-3ow2O:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3ow2 50S RIBOSOMAL
PROTEIN L32E
(Haloarcula
marismortui) 		5 / 10 LEU X 116
ASP X 113
ALA X 114
ALA X 173
SER X 110
 C  01267 ( 4.8A)
None
None
None
None
 1.46A 3rodC-3ow2X:
undetectable		 3rodC-3ow2X:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3ow2 50S RIBOSOMAL
PROTEIN L5P
(Haloarcula
marismortui) 		3 / 4 SER D 105
GLY D  26
GLU D  60
 G  02338 ( 3.6A)
C  02346 ( 4.2A)
A  02345 ( 3.5A)
 0.60A 4juoA-3ow2D:
undetectable
4juoC-3ow2D:
undetectable		 4juoA-3ow2D:
17.62
4juoC-3ow2D:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3ow2 50S RIBOSOMAL
PROTEIN L39E
(Haloarcula
marismortui) 		3 / 3 LEU 1  11
LYS 1   8
THR 1   7
 G  01417 ( 3.5A)
U  01677 ( 2.4A)
A  0 120 ( 4.2A)
 0.56A 4lj0A-3ow21:
undetectable		 4lj0A-3ow21:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		4 / 8 GLY A 157
ILE A  88
GLU A  98
LEU A  94
 None
 0.78A 4mwzB-3ow2A:
undetectable		 4mwzB-3ow2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		5 / 12 ASN A 107
VAL A 108
ALA A 126
ASN A 125
GLY A 160
 None
 1.25A 4qckA-3ow2A:
2.4		 4qckA-3ow2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3ow2 50S RIBOSOMAL
PROTEIN L29P
(Haloarcula
marismortui) 		4 / 8 LEU U  49
ASN U  29
ALA U  30
VAL U  33
 None
 0.81A 4zbqA-3ow2U:
2.5		 4zbqA-3ow2U:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		5 / 12 GLY A  91
ILE A  68
VAL A  74
VAL A  42
VAL A  58
 None
 1.08A 5dpdA-3ow2A:
undetectable		 5dpdA-3ow2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		5 / 12 GLY A  91
ILE A  68
VAL A  74
VAL A  42
VAL A  58
 None
 1.10A 5dpdB-3ow2A:
undetectable		 5dpdB-3ow2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		4 / 6 ALA A  53
SER A  52
ALA A 121
SER A 122
 None
A  01653 ( 2.6A)
A  01875 ( 3.3A)
C  01876 ( 4.6A)
 0.90A 6bocA-3ow2A:
undetectable
6bocB-3ow2A:
undetectable
6bocC-3ow2A:
undetectable
6bocD-3ow2A:
undetectable		 6bocA-3ow2A:
6.33
6bocB-3ow2A:
6.33
6bocC-3ow2A:
6.33
6bocD-3ow2A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3ow2 50S RIBOSOMAL
PROTEIN L2P
(Haloarcula
marismortui) 		4 / 4 HIS A 131
VAL A 138
LEU A 128
ALA A 136
 None
 1.35A 6d8pB-3ow2A:
undetectable		 6d8pB-3ow2A:
16.56