SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ow8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA8_0
(GRAMICIDIN A)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 4 VAL A  70
TRP A  20
VAL A  68
TRP A 278
 None
 1.24A 1micA-3ow8A:
undetectable
1micB-3ow8A:
undetectable		 1micA-3ow8A:
11.11
1micB-3ow8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 6 SER A 153
ILE A 193
ALA A 208
ALA A 239
 None
 0.92A 1w0gA-3ow8A:
undetectable		 1w0gA-3ow8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 6 ALA A  86
ALA A 109
THR A 123
PHE A 133
 None
 1.05A 2xfhA-3ow8A:
undetectable		 2xfhA-3ow8A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 6 HIS A  87
ALA A 109
THR A 123
PHE A 133
 None
 1.06A 2xfhA-3ow8A:
undetectable		 2xfhA-3ow8A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 8 SER A 165
LEU A 163
ASN A 173
GLY A 180
 None
 0.85A 3dcjB-3ow8A:
undetectable		 3dcjB-3ow8A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		5 / 12 GLY A 128
GLY A 170
GLY A 148
ASP A 211
ILE A 193
 None
 0.99A 3gczA-3ow8A:
undetectable		 3gczA-3ow8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		5 / 12 PHE A   9
GLN A  11
VAL A 277
VAL A 256
ILE A   7
 None
 1.07A 3gwxB-3ow8A:
undetectable		 3gwxB-3ow8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 6 LEU A 121
PHE A 114
ILE A  78
ALA A  79
 None
 0.89A 3mdrA-3ow8A:
undetectable		 3mdrA-3ow8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		3 / 3 TRP A 278
VAL A  22
TRP A  20
 None
UNX  A 307 ( 4.4A)
None
 1.01A 3zq8A-3ow8A:
undetectable
3zq8B-3ow8A:
undetectable		 3zq8A-3ow8A:
11.11
3zq8B-3ow8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		5 / 12 LEU A 204
HIS A 189
VAL A 206
GLY A 262
LEU A 228
 None
 0.97A 4m2vA-3ow8A:
undetectable		 4m2vA-3ow8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		3 / 3 SER A 291
TYR A 301
ASP A 295
 None
 0.85A 4rp8C-3ow8A:
undetectable		 4rp8C-3ow8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		5 / 12 GLY A 128
GLY A 170
GLY A 148
ASP A 211
ILE A 193
 None
 1.02A 5ehiA-3ow8A:
undetectable		 5ehiA-3ow8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		5 / 12 GLY A 128
GLY A 170
GLY A 148
ASP A 211
ILE A 193
 None
 1.06A 5ehiC-3ow8A:
undetectable		 5ehiC-3ow8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 6 TYR A 301
TYR A 282
GLY A 279
ASP A 294
 None
None
UNX  A 307 ( 3.9A)
UNX  A1001 ( 3.5A)
 1.27A 5emlA-3ow8A:
undetectable		 5emlA-3ow8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		3 / 3 GLN A  11
TRP A  47
VAL A  35
 None
 0.67A 6auuA-3ow8A:
undetectable		 6auuA-3ow8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 5 GLY A 124
THR A 123
SER A  83
SER A  82
 None
 0.77A 6jmjA-3ow8A:
undetectable		 6jmjA-3ow8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 7 GLY A 124
THR A 123
SER A  83
SER A  82
 None
 0.80A 6jnhA-3ow8A:
undetectable		 6jnhA-3ow8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens) 		4 / 6 GLY A 124
THR A 123
SER A  83
SER A  82
 None
 0.81A 6jogA-3ow8A:
undetectable		 6jogA-3ow8A:
19.75