SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3owa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 GLU A 504
ALA A 502
SER A 498
 None
 0.71A 1errB-3owaA:
1.8		 1errB-3owaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 GLU A 504
ALA A 506
SER A 320
 None
 0.55A 1errB-3owaA:
1.8		 1errB-3owaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 ILE A 582
LYS A 314
ALA A 317
VAL A 531
 None
1PE  A 602 (-2.8A)
None
None
 0.99A 1hk1A-3owaA:
1.0		 1hk1A-3owaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 GLU A  28
VAL A 594
HIS A  34
GLU A 100
 None
 1.27A 1s3zA-3owaA:
undetectable
1s3zB-3owaA:
undetectable		 1s3zA-3owaA:
14.43
1s3zB-3owaA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 PHE A 193
ALA A 190
ILE A 118
ILE A 261
LEU A 139
 None
 1.31A 2bjfA-3owaA:
undetectable		 2bjfA-3owaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 ASP A  22
ARG A 324
LEU A 508
GLU A 504
 None
 1.09A 2cdqB-3owaA:
undetectable		 2cdqB-3owaA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 GLY A  78
GLY A  72
ALA A  71
LEU A 136
LEU A 139
 None
 0.91A 2nyuA-3owaA:
undetectable		 2nyuA-3owaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 HIS A 112
HIS A 115
GLY A 265
ILE A 264
VAL A 124
 None
 1.30A 2uxpB-3owaA:
undetectable		 2uxpB-3owaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 VAL A 497
ILE A 496
LEU A 483
GLY A 473
ALA A 476
 None
 1.28A 2xf3B-3owaA:
undetectable		 2xf3B-3owaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 VAL A 497
ILE A 496
LEU A 483
GLY A 473
ALA A 476
 None
 1.29A 2xfsB-3owaA:
undetectable		 2xfsB-3owaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 VAL A 497
ILE A 496
LEU A 483
GLY A 473
ALA A 476
 None
 1.28A 2xh9B-3owaA:
undetectable		 2xh9B-3owaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ARG A 509
TYR A 323
LEU A  97
GLY A 327
ASP A  22
 None
 1.15A 2zznA-3owaA:
undetectable		 2zznA-3owaA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 GLU A 130
GLU A 210
ASN A 246
 None
 0.73A 3lp9B-3owaA:
undetectable
3lp9D-3owaA:
undetectable		 3lp9B-3owaA:
19.16
3lp9D-3owaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ALA A 348
ILE A 257
GLY A 127
PHE A 126
TYR A 135
 None
 1.22A 3nrrA-3owaA:
undetectable		 3nrrA-3owaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 LEU A  67
GLY A 107
GLU A  57
ALA A 105
 None
 0.95A 3tehB-3owaA:
undetectable		 3tehB-3owaA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 SER A 187
ILE A 236
VAL A 216
LEU A 237
VAL A 195
 None
 1.14A 3w67A-3owaA:
undetectable		 3w67A-3owaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT2_A_ASDA1490_1
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 10 GLU A 367
ALA A 318
VAL A 274
PHE A 532
SER A 498
 None
None
None
1PE  A 602 (-4.4A)
None
 1.37A 4at2A-3owaA:
0.0		 4at2A-3owaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 GLY A  87
GLY A  78
VAL A 124
HIS A 115
 None
 0.81A 4c5nC-3owaA:
undetectable		 4c5nC-3owaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 ILE A 227
ASP A 397
ARG A 393
VAL A  49
 None
 1.02A 4oltA-3owaA:
3.7		 4oltA-3owaA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 ILE A 227
ASP A 397
ARG A 393
VAL A  49
 None
 1.05A 4oltB-3owaA:
0.9		 4oltB-3owaA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 SER A  64
GLY A 106
GLY A 107
THR A 111
ASP A 397
 None
 1.08A 4pghA-3owaA:
undetectable		 4pghA-3owaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 SER A  64
GLY A 106
GLY A 107
THR A 111
ASP A 397
 None
 1.06A 4pghD-3owaA:
undetectable		 4pghD-3owaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 TYR A 354
TYR A 501
LEU A 360
PHE A  14
 None
 1.36A 4twdF-3owaA:
undetectable
4twdG-3owaA:
0.9		 4twdF-3owaA:
18.12
4twdG-3owaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 TRP A 183
THR A 232
THR A 234
SER A 187
 FAD  A 601 (-4.2A)
FAD  A 601 ( 3.9A)
None
None
 1.44A 5b6iB-3owaA:
undetectable		 5b6iB-3owaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 THR A 185
ALA A 114
ASN A 186
 FAD  A 601 (-3.9A)
None
None
 0.34A 5ersA-3owaA:
undetectable		 5ersA-3owaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 ALA A 318
THR A 315
TYR A 316
VAL A 322
 None
 0.86A 6cduA-3owaA:
3.8
6cduE-3owaA:
3.6		 6cduA-3owaA:
20.07
6cduE-3owaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 VAL A 322
ALA A 318
THR A 315
TYR A 316
 None
 0.85A 6cduD-3owaA:
3.7
6cduE-3owaA:
3.6		 6cduD-3owaA:
20.07
6cduE-3owaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 VAL A 322
ALA A 318
THR A 315
TYR A 316
 None
 0.83A 6cduH-3owaA:
3.7
6cduI-3owaA:
3.4		 6cduH-3owaA:
20.07
6cduI-3owaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 ILE A 199
TYR A 175
LEU A 247
SER A 205
 None
 1.10A 6f6jA-3owaA:
undetectable		 6f6jA-3owaA:
undetectable