SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3owt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 707
PHE A 773
MET A 772
TYR A 768
LEU A 755
 None
 1.36A 1brpA-3owtA:
undetectable		 1brpA-3owtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.87A 2eilN-3owtA:
undetectable
2eilW-3owtA:
undetectable		 2eilN-3owtA:
13.87
2eilW-3owtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 746
GLY A 745
PHE A 716
PHE A 773
 None
 0.99A 2vctD-3owtA:
undetectable		 2vctD-3owtA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 768
PHE A 769
PHE A 703
ILE A 754
 None
 1.22A 2zseA-3owtA:
undetectable		 2zseA-3owtA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 769
MET A 717
PHE A 716
PHE A 707
 None
 1.47A 3af3A-3owtA:
undetectable		 3af3A-3owtA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 689
SER A 712
ASP A 687
GLU A 722
 None
 1.04A 3sg9B-3owtA:
undetectable		 3sg9B-3owtA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 720
HIS A 721
MET A 717
 None
 0.65A 3thrD-3owtA:
undetectable		 3thrD-3owtA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 766
LEU A 758
LEU A 755
ILE A 724
 None
 0.89A 3u5kD-3owtA:
undetectable		 3u5kD-3owtA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3owt DNA-BINDING PROTEIN
RAP1
REGULATORY PROTEIN
SIR3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ASP C 464
GLY A 760
THR C 467
PHE A 821
 None
 1.00A 3vnsA-3owtC:
undetectable		 3vnsA-3owtC:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 684
ARG A 814
PRO A 784
 None
 1.06A 4wanC-3owtA:
undetectable		 4wanC-3owtA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.84A 5b1bN-3owtA:
undetectable
5b1bW-3owtA:
undetectable		 5b1bN-3owtA:
13.87
5b1bW-3owtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.86A 5b3sN-3owtA:
undetectable
5b3sW-3owtA:
undetectable		 5b3sN-3owtA:
13.87
5b3sW-3owtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.86A 5iy5N-3owtA:
undetectable
5iy5W-3owtA:
undetectable		 5iy5N-3owtA:
13.87
5iy5W-3owtA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.86A 5zcoA-3owtA:
undetectable
5zcoJ-3owtA:
undetectable		 5zcoA-3owtA:
13.87
5zcoJ-3owtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3owt DNA-BINDING PROTEIN
RAP1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.87A 5zcqN-3owtA:
undetectable
5zcqW-3owtA:
undetectable		 5zcqN-3owtA:
13.87
5zcqW-3owtA:
15.83