SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 205
TYR A  80
LEU A 144
 None
 1.06A 1kxhA-3oxhA:
undetectable		 1kxhA-3oxhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 126
SER A 114
VAL A 100
ALA A 123
 None
 0.78A 3ax9A-3oxhA:
undetectable		 3ax9A-3oxhA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  93
VAL A  94
GLY A  97
PRO A 119
 None
 0.89A 3bjwA-3oxhA:
undetectable		 3bjwA-3oxhA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 161
VAL A 164
ILE A 116
ASP A 118
 None
 1.22A 3bu1A-3oxhA:
undetectable		 3bu1A-3oxhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 132
GLY A 134
ASN A  13
TYR A  80
 PMB  A 301 ( 4.0A)
None
None
None
 1.14A 3ccfA-3oxhA:
undetectable		 3ccfA-3oxhA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 161
VAL A 100
THR A 117
PHE A 160
 None
 1.23A 3ltwA-3oxhA:
undetectable		 3ltwA-3oxhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 214
ASP A 215
ASP A 213
GLY A 239
ILE A 235
 None
 1.14A 3spkA-3oxhA:
undetectable		 3spkA-3oxhA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 183
LYS A 184
VAL A 165
TYR A 161
GLY A 166
 None
 1.04A 4b3oA-3oxhA:
undetectable		 4b3oA-3oxhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 116
HIS A -13
HIS A -12
HIS A -11
 None
None
None
PMB  A 301 (-3.1A)
 0.88A 4n16A-3oxhA:
undetectable		 4n16A-3oxhA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 160
PRO A  95
VAL A  93
ALA A 163
 None
 1.30A 4w5oA-3oxhA:
undetectable		 4w5oA-3oxhA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 160
PRO A  95
VAL A  93
ALA A 163
 None
 1.32A 4z4dA-3oxhA:
undetectable		 4z4dA-3oxhA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 160
PRO A  95
VAL A  93
ALA A 163
 None
 1.32A 4z4eA-3oxhA:
undetectable		 4z4eA-3oxhA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  19
ALA A  25
LYS A  27
 None
 0.73A 6fgcA-3oxhA:
undetectable		 6fgcA-3oxhA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3oxh RV0577 PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  19
ALA A  25
LYS A  27
 None
 0.72A 6fgdA-3oxhA:
undetectable		 6fgdA-3oxhA:
22.36