SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		3 / 3 GLN A  29
TYR A  46
ARG A  47
 None
 0.79A 1gtbA-3oxpA:
undetectable		 1gtbA-3oxpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 12 ALA A  36
LEU A   5
SER A 110
LEU A 118
TYR A  41
 None
 1.25A 3ia4A-3oxpA:
undetectable		 3ia4A-3oxpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 12 ALA A  36
LEU A   5
SER A 110
LEU A 118
TYR A  41
 None
 1.28A 3ia4B-3oxpA:
undetectable		 3ia4B-3oxpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 12 ALA A  36
LEU A   5
SER A 110
LEU A 118
TYR A  41
 None
 1.25A 3ia4C-3oxpA:
undetectable		 3ia4C-3oxpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		3 / 3 LEU A 103
HIS A  66
MET A  64
 None
 0.83A 3thrD-3oxpA:
undetectable		 3thrD-3oxpA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 12 LEU A  80
MET A   1
LEU A   2
ILE A 115
HIS A 111
 None
 1.31A 4j26B-3oxpA:
undetectable		 4j26B-3oxpA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 12 ALA A  36
LEU A   5
SER A 110
LEU A 118
TYR A  41
 None
 1.24A 4q0dC-3oxpA:
undetectable		 4q0dC-3oxpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 12 ALA A  36
LEU A   5
SER A 110
LEU A 118
TYR A  41
 None
 1.24A 4q0dD-3oxpA:
undetectable		 4q0dD-3oxpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 12 ALA A  36
LEU A   5
SER A 110
LEU A 118
TYR A  41
 None
 1.11A 5hi6B-3oxpA:
undetectable		 5hi6B-3oxpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3oxp PHOSPHOTRANSFERASE
ENZYME II, A
COMPONENT
(Yersinia
pestis) 		5 / 9 ILE A  62
ILE A  83
PRO A  65
VAL A 102
ILE A 101
 None
 1.13A 5kr0A-3oxpA:
undetectable		 5kr0A-3oxpA:
21.01