SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		5 / 10 ALA A 221
ASP A 222
ASP A 223
ILE A 178
GLY A 215
 None
 1.09A 1d4yA-3oyrA:
undetectable		 1d4yA-3oyrA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 6 ALA A 283
TYR A 227
ILE A 255
ILE A 287
 None
 0.94A 2dcfA-3oyrA:
undetectable		 2dcfA-3oyrA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		3 / 3 VAL A 135
GLU A 132
GLU A 136
 None
 0.78A 2nv4A-3oyrA:
undetectable		 2nv4A-3oyrA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		5 / 10 SER A 196
ALA A  67
ALA A  70
ALA A  66
SER A 190
 None
 1.15A 2r2vC-3oyrA:
undetectable
2r2vF-3oyrA:
undetectable
2r2vG-3oyrA:
undetectable		 2r2vC-3oyrA:
9.71
2r2vF-3oyrA:
9.71
2r2vG-3oyrA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 7 ALA A 283
TYR A 227
ILE A 255
ILE A 287
 None
 0.93A 2zm7A-3oyrA:
undetectable		 2zm7A-3oyrA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 8 ALA A 283
TYR A 227
ILE A 255
ILE A 287
 None
 0.92A 2zm8A-3oyrA:
undetectable		 2zm8A-3oyrA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 8 ALA A 283
TYR A 227
ILE A 255
ILE A 287
 None
 0.92A 2zmaA-3oyrA:
undetectable		 2zmaA-3oyrA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 8 SER A 258
ARG A 257
LEU A 251
ALA A 292
 None
 1.02A 3ax7A-3oyrA:
undetectable		 3ax7A-3oyrA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 5 SER A 150
MET A 134
PHE A 131
ILE A  87
 None
 1.24A 3g59A-3oyrA:
0.0		 3g59A-3oyrA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 8 SER A 258
ARG A 257
LEU A 251
ALA A 292
 None
 0.96A 3ns1L-3oyrA:
1.1		 3ns1L-3oyrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		5 / 12 LEU A 323
GLU A  22
ALA A  21
LEU A  61
ALA A  23
 None
 1.14A 3ou6C-3oyrA:
undetectable		 3ou6C-3oyrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		5 / 11 ALA A 221
ASP A 222
ASP A 223
ILE A 178
GLY A 215
 None
 1.14A 3spkA-3oyrA:
undetectable		 3spkA-3oyrA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		3 / 3 LEU A 299
ASP A 302
TYR A 303
 None
 0.42A 4qc6B-3oyrA:
undetectable		 4qc6B-3oyrA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 7 LEU A 175
ASN A 213
LEU A 216
LEU A 220
 None
 0.66A 4wg0B-3oyrA:
undetectable
4wg0C-3oyrA:
undetectable		 4wg0B-3oyrA:
3.54
4wg0C-3oyrA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 7 ASN A 213
LEU A 216
LEU A 220
LEU A 175
 None
 0.71A 4wg0L-3oyrA:
undetectable
4wg0M-3oyrA:
undetectable		 4wg0L-3oyrA:
3.54
4wg0M-3oyrA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		5 / 12 LEU A 293
ALA A 295
ILE A 288
GLY A 289
LEU A 297
 None
 0.97A 5nfjA-3oyrA:
undetectable		 5nfjA-3oyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		5 / 12 LEU A 293
ALA A 295
ILE A 288
GLY A 289
LEU A 297
 None
 0.97A 5nfjB-3oyrA:
undetectable		 5nfjB-3oyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		5 / 12 LEU A 293
ALA A 295
ILE A 288
GLY A 289
LEU A 297
 None
 0.97A 5nfjC-3oyrA:
undetectable		 5nfjC-3oyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		3 / 3 LYS A  79
LEU A  31
ARG A  35
 None
 0.78A 5yw0A-3oyrA:
undetectable		 5yw0A-3oyrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 5 GLU A 176
VAL A 173
LEU A 169
HIS A 165
 None
 1.39A 6dyoA-3oyrA:
undetectable		 6dyoA-3oyrA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 4 ALA A 304
ALA A 307
ALA A 327
ALA A 330
 None
 0.49A 6gtqA-3oyrA:
undetectable
6gtqB-3oyrA:
undetectable		 6gtqA-3oyrA:
19.77
6gtqB-3oyrA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE
(Caulobacter
vibrioides) 		4 / 4 ALA A 327
ALA A 330
ALA A 304
ALA A 307
 None
 0.48A 6gtqA-3oyrA:
undetectable
6gtqB-3oyrA:
undetectable		 6gtqA-3oyrA:
19.77
6gtqB-3oyrA:
19.77