SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 8 SER A 106
VAL A 143
SER A 144
ASN A 157
 None
 1.21A 1hwiB-3oytA:
undetectable		 1hwiB-3oytA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 8 SER A 106
VAL A 143
SER A 144
ASN A 157
 None
 1.17A 1hwkA-3oytA:
undetectable		 1hwkA-3oytA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 8 SER A 106
VAL A 143
SER A 144
ASN A 157
 None
 1.15A 1hwkC-3oytA:
undetectable		 1hwkC-3oytA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 8 SER A 106
VAL A 143
SER A 144
ASN A 157
 None
 1.15A 1hwkD-3oytA:
undetectable		 1hwkD-3oytA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 VAL A 279
ALA A 278
HIS A 299
 None
 0.76A 1q23G-3oytA:
undetectable		 1q23G-3oytA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 VAL A 279
ALA A 278
HIS A 299
 None
 0.73A 1q23J-3oytA:
undetectable		 1q23J-3oytA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ILE A 185
GLY A   8
ILE A  85
VAL A   5
GLU A 243
 None
 1.09A 1sg9A-3oytA:
undetectable		 1sg9A-3oytA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 8 GLY A 172
GLY A 262
THR A 399
ALA A 398
ALA A 263
 None
 0.95A 2ej3A-3oytA:
undetectable		 2ej3A-3oytA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 10 GLY A 172
GLY A 262
THR A 399
ALA A 398
ALA A 263
 None
 0.93A 2ej3B-3oytA:
undetectable		 2ej3B-3oytA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 ARG A 280
SER A 274
GLY A 395
THR A 396
 None
 1.14A 2f7fA-3oytA:
undetectable		 2f7fA-3oytA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ALA A 233
SER A 335
ALA A 339
GLY A  50
TYR A 223
 None
 1.10A 2igtA-3oytA:
undetectable		 2igtA-3oytA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ALA A 233
SER A 335
ALA A 339
GLY A  50
TYR A 223
 None
 1.09A 2igtB-3oytA:
undetectable		 2igtB-3oytA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ALA A 233
SER A 335
ALA A 339
GLY A  50
TYR A 223
 None
 1.08A 2igtC-3oytA:
undetectable		 2igtC-3oytA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 ASP A 228
ARG A 227
ARG A 221
 None
 0.89A 2j9dA-3oytA:
undetectable
2j9dC-3oytA:
undetectable		 2j9dA-3oytA:
17.60
2j9dC-3oytA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 THR A 301
ALA A 339
ALA A 398
THR A 396
PRO A 273
 None
 1.15A 2ve3B-3oytA:
undetectable		 2ve3B-3oytA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 GLY A 260
ALA A 285
ASN A 389
SER A 167
GLY A 340
 None
 1.08A 2vmyA-3oytA:
undetectable		 2vmyA-3oytA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 11 SER A 326
LEU A  26
MET A 331
ILE A  15
ALA A 338
 None
 1.11A 2zbzA-3oytA:
undetectable		 2zbzA-3oytA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 10 GLU A 192
GLY A 333
ALA A 219
PHE A  39
THR A  34
 None
 1.28A 3a3yA-3oytA:
undetectable		 3a3yA-3oytA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 9 LEU A 102
ILE A 153
GLY A 155
SER A 159
SER A 141
 None
 1.09A 3ai9X-3oytA:
undetectable		 3ai9X-3oytA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 6 GLY A 235
GLY A 191
GLY A 190
GLY A 236
GLY A 189
 None
 1.36A 3bogA-3oytA:
undetectable
3bogC-3oytA:
undetectable		 3bogA-3oytA:
undetectable
3bogC-3oytA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 6 GLY A 235
GLY A 236
GLY A 237
GLY A 191
GLY A 189
 None
 1.50A 3bogA-3oytA:
undetectable
3bogC-3oytA:
undetectable		 3bogA-3oytA:
undetectable
3bogC-3oytA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 MET A 331
VAL A  22
GLU A 343
 None
None
K  A 408 (-3.5A)
 0.91A 3c6gA-3oytA:
undetectable		 3c6gA-3oytA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 LEU A  79
ALA A 338
VAL A 341
GLY A  10
VAL A  66
 None
 1.08A 3c6gB-3oytA:
undetectable		 3c6gB-3oytA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 8 GLY A 234
GLY A 235
GLY A 236
ILE A  11
SER A  14
 None
 0.95A 3d41A-3oytA:
undetectable		 3d41A-3oytA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 GLY A 395
GLY A 306
GLY A 392
LEU A 311
ASP A 366
 None
 0.99A 3gczA-3oytA:
undetectable		 3gczA-3oytA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 SER A 106
GLY A 109
SER A  74
 None
 0.48A 3loqA-3oytA:
undetectable		 3loqA-3oytA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 SER A 327
GLY A 300
SER A 220
 None
 0.66A 3loqA-3oytA:
undetectable		 3loqA-3oytA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 11 VAL A 239
ALA A 188
GLY A 189
ALA A 398
LEU A 348
 None
 1.21A 3rc0A-3oytA:
undetectable		 3rc0A-3oytA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 9 PHE A 230
ALA A 339
PHE A 202
PHE A 393
ALA A 163
 None
 1.40A 3t3sA-3oytA:
undetectable		 3t3sA-3oytA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 10 TYR A 261
ILE A 258
SER A 388
ILE A 171
ALA A 174
 None
None
K  A 408 (-2.9A)
None
None
 1.42A 3u6tA-3oytA:
undetectable		 3u6tA-3oytA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 7 ASN A 157
LEU A 102
GLY A 142
SER A  74
 None
 0.99A 4cp3A-3oytA:
undetectable
4cp3B-3oytA:
undetectable		 4cp3A-3oytA:
15.37
4cp3B-3oytA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 8 ILE A  62
LEU A  67
ILE A  75
ASP A  72
 None
 0.88A 4dtaB-3oytA:
undetectable		 4dtaB-3oytA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 ALA A 344
LEU A 400
VAL A 401
GLU A 257
 None
 1.01A 4g24A-3oytA:
undetectable		 4g24A-3oytA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ILE A  15
GLY A  50
GLY A  32
ILE A 232
LEU A 336
 None
 0.99A 4iv0A-3oytA:
undetectable		 4iv0A-3oytA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 8 TYR A 255
LEU A 349
VAL A  22
HIS A 253
 None
 0.84A 4l1xA-3oytA:
undetectable		 4l1xA-3oytA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		6 / 12 ALA A 163
CYH A 164
HIS A 299
THR A 301
HIS A 334
GLY A 392
 None
 1.19A 4ls7A-3oytA:
61.7		 4ls7A-3oytA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		9 / 12 GLY A 107
ALA A 163
GLU A 192
PHE A 202
HIS A 299
THR A 301
HIS A 334
LEU A 336
GLY A 392
 None
 0.68A 4ls7A-3oytA:
61.7		 4ls7A-3oytA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		7 / 12 GLY A 107
ALA A 163
GLU A 192
PHE A 202
LEU A 336
GLY A 392
PHE A 393
 None
 0.64A 4ls7A-3oytA:
61.7		 4ls7A-3oytA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		7 / 12 GLY A 337
ALA A 163
GLU A 192
PHE A 202
HIS A 299
LEU A 336
GLY A 392
 None
 1.47A 4ls7A-3oytA:
61.7		 4ls7A-3oytA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		6 / 12 ALA A 163
CYH A 164
HIS A 299
THR A 301
HIS A 334
GLY A 392
 None
 1.19A 4ls7A-3oytA:
61.7
4ls7B-3oytA:
61.1		 4ls7A-3oytA:
41.61
4ls7B-3oytA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		7 / 12 ALA A 163
PHE A 202
HIS A 299
THR A 301
HIS A 334
LEU A 336
GLY A 392
 None
 0.66A 4ls7A-3oytA:
61.7
4ls7B-3oytA:
61.1		 4ls7A-3oytA:
41.61
4ls7B-3oytA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ALA A 163
PHE A 202
LEU A 336
GLY A 392
PHE A 393
 None
 0.65A 4ls7A-3oytA:
61.7
4ls7B-3oytA:
61.1		 4ls7A-3oytA:
41.61
4ls7B-3oytA:
41.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 PHE A 318
LEU A 311
VAL A 298
GLY A 262
MET A 387
 None
 1.29A 4mubA-3oytA:
undetectable		 4mubA-3oytA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ILE A  15
GLY A  50
GLY A  32
ILE A 232
LEU A 336
 None
 1.04A 4mwzA-3oytA:
undetectable		 4mwzA-3oytA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ILE A  15
GLY A  50
GLY A  32
ILE A 232
LEU A 336
 None
 0.97A 4mwzB-3oytA:
undetectable		 4mwzB-3oytA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 5 ARG A 403
THR A 384
THR A 385
ASP A 294
 None
 1.05A 4oltB-3oytA:
undetectable		 4oltB-3oytA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 8 THR A   7
SER A  88
GLU A 352
TYR A 405
 None
 1.26A 4qb9D-3oytA:
undetectable		 4qb9D-3oytA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 ARG A   3
ARG A 403
VAL A 289
ASP A 290
 None
 1.29A 4xqeA-3oytA:
undetectable		 4xqeA-3oytA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 ARG A   3
ARG A 403
VAL A 289
ASP A 290
 None
 1.29A 4xqeB-3oytA:
undetectable		 4xqeB-3oytA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 7 GLY A 236
GLY A 237
ALA A 338
ILE A 345
 None
 0.74A 4yjiA-3oytA:
undetectable		 4yjiA-3oytA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 5 SER A 220
ARG A  30
GLY A  29
GLU A  28
 None
 1.17A 5btiA-3oytA:
undetectable
5btiB-3oytA:
undetectable		 5btiA-3oytA:
21.90
5btiB-3oytA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ALA A  73
GLY A 337
GLY A 191
GLY A 237
LEU A 336
 None
 1.04A 5c0oE-3oytA:
undetectable		 5c0oE-3oytA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 5 THR A 264
GLY A 277
GLU A 310
HIS A 299
 None
 1.14A 5c0oH-3oytA:
undetectable		 5c0oH-3oytA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 ASN A 373
ALA A 324
ARG A 381
 None
 0.74A 5cvtB-3oytA:
undetectable		 5cvtB-3oytA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 7 GLU A 343
GLY A 333
SER A 335
GLY A 234
 K  A 408 (-3.5A)
None
None
None
 1.00A 5e26A-3oytA:
undetectable
5e26B-3oytA:
undetectable		 5e26A-3oytA:
25.05
5e26B-3oytA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 ILE A  15
VAL A  12
ALA A  73
GLY A 107
THR A 166
 None
 1.25A 5igpA-3oytA:
undetectable		 5igpA-3oytA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 5 GLU A 343
GLY A 333
SER A 335
GLY A 234
 K  A 408 (-3.5A)
None
None
None
 1.05A 5kprA-3oytA:
undetectable		 5kprA-3oytA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		6 / 12 GLY A 340
ALA A 168
ILE A 160
GLY A 105
VAL A 241
ILE A 171
 None
 1.41A 5kqxA-3oytA:
undetectable		 5kqxA-3oytA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		3 / 3 VAL A 241
LYS A   2
MET A   1
 None
 1.08A 5nknA-3oytA:
undetectable		 5nknA-3oytA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 GLY A 333
VAL A 271
LEU A 336
GLY A 392
GLY A 229
 None
 1.21A 5tuiB-3oytA:
undetectable		 5tuiB-3oytA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 10 GLY A 189
GLY A 190
LEU A 348
ILE A  11
LEU A   9
 None
 1.00A 5vm8B-3oytA:
undetectable		 5vm8B-3oytA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 GLY A 237
GLY A 337
GLY A 191
VAL A 104
ALA A 339
 None
 0.85A 5x7fA-3oytA:
undetectable		 5x7fA-3oytA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 TYR A  76
GLU A  83
GLY A 235
GLY A 234
 None
 0.98A 5x7pB-3oytA:
undetectable		 5x7pB-3oytA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 7 GLU A 310
ARG A 227
THR A 301
PRO A 273
 None
 1.42A 6a4iB-3oytA:
undetectable		 6a4iB-3oytA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 SER A  14
ALA A 338
ALA A 233
SER A 335
 None
 1.03A 6bocA-3oytA:
undetectable
6bocB-3oytA:
undetectable
6bocC-3oytA:
undetectable
6bocD-3oytA:
undetectable		 6bocA-3oytA:
8.06
6bocB-3oytA:
8.06
6bocC-3oytA:
8.06
6bocD-3oytA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 SER A 106
SER A 159
ALA A  73
SER A  74
 None
 0.93A 6bocA-3oytA:
undetectable
6bocB-3oytA:
undetectable
6bocC-3oytA:
undetectable
6bocD-3oytA:
undetectable		 6bocA-3oytA:
8.06
6bocB-3oytA:
8.06
6bocC-3oytA:
8.06
6bocD-3oytA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		4 / 6 SER A 159
ALA A  73
SER A  74
SER A 106
 None
 0.94A 6bocA-3oytA:
undetectable
6bocB-3oytA:
undetectable
6bocC-3oytA:
undetectable
6bocD-3oytA:
undetectable		 6bocA-3oytA:
8.06
6bocB-3oytA:
8.06
6bocC-3oytA:
8.06
6bocD-3oytA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I
(Yersinia
pestis) 		5 / 12 GLY A 333
VAL A  22
GLY A 236
GLY A 235
ILE A  15
 None
 0.89A 6dj1A-3oytA:
undetectable		 6dj1A-3oytA:
11.06