SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		5 / 12 SER A 150
LEU A 146
MET A  85
VAL A 140
ILE A 105
 None
None
CL  A 704 ( 4.1A)
None
None
 1.45A 1uobA-3oyzA:
undetectable		 1uobA-3oyzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		5 / 12 THR A  19
GLY A 362
ASP A  60
ASP A  49
HIS A 101
 None
None
None
ACO  A 434 (-4.7A)
CL  A 704 (-4.0A)
 1.18A 1wg8B-3oyzA:
undetectable		 1wg8B-3oyzA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		3 / 3 GLU A 426
HIS A 413
GLU A 417
 None
 0.63A 2x45B-3oyzA:
undetectable		 2x45B-3oyzA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		3 / 3 GLU A 426
HIS A 413
GLU A 417
 None
 0.58A 2x45C-3oyzA:
undetectable		 2x45C-3oyzA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 8 GLU A  80
VAL A 226
LEU A 185
ALA A 152
 None
CL  A 705 ( 4.0A)
None
None
 0.93A 3ax7A-3oyzA:
undetectable		 3ax7A-3oyzA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 7 ASP A 192
PRO A 122
GLU A 158
ARG A  59
 MG  A 500 ( 2.9A)
None
MG  A 500 ( 2.6A)
None
 1.27A 3s3oA-3oyzA:
undetectable		 3s3oA-3oyzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 7 GLU A  80
VAL A 226
LEU A 185
ALA A 152
 None
CL  A 705 ( 4.0A)
None
None
 0.94A 3uniA-3oyzA:
undetectable		 3uniA-3oyzA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		3 / 3 GLU A 161
GLY A 126
SER A 159
 None
 0.54A 4b53B-3oyzA:
undetectable		 4b53B-3oyzA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		3 / 3 ASP A 188
ARG A  89
THR A 216
 None
 0.68A 4i13A-3oyzA:
undetectable		 4i13A-3oyzA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 5 VAL A  45
LEU A 185
VAL A 187
PHE A  14
 None
 1.02A 4lb0B-3oyzA:
undetectable		 4lb0B-3oyzA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 5 ILE A 121
ARG A  89
ASP A 192
VAL A  47
 None
None
MG  A 500 ( 2.9A)
None
 1.09A 4nkxC-3oyzA:
undetectable		 4nkxC-3oyzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 5 ILE A 121
ARG A  89
ASP A 192
VAL A  47
 None
None
MG  A 500 ( 2.9A)
None
 1.09A 4nkxD-3oyzA:
undetectable		 4nkxD-3oyzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		3 / 3 ASP A 188
ARG A  89
THR A 216
 None
 0.66A 4p3rA-3oyzA:
undetectable		 4p3rA-3oyzA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		5 / 12 GLU A 190
GLY A 189
TYR A 232
ILE A 157
SER A 159
 None
PYR  A 435 (-3.2A)
None
None
None
 1.45A 4xudA-3oyzA:
undetectable		 4xudA-3oyzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 6 TYR A 406
ILE A 399
VAL A 425
ALA A 428
 None
 0.77A 5cu6A-3oyzA:
undetectable		 5cu6A-3oyzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 6 PRO A 341
VAL A 424
TYR A 420
ILE A 346
 None
 0.90A 5pbeA-3oyzA:
undetectable		 5pbeA-3oyzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 7 GLU A  72
SER A  71
VAL A  69
ARG A  38
 None
 1.19A 6av6C-3oyzA:
undetectable
6av6D-3oyzA:
undetectable		 6av6C-3oyzA:
13.17
6av6D-3oyzA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3oyz MALATE SYNTHASE
(Haloferax
volcanii) 		4 / 6 GLU A  51
ARG A  84
VAL A 191
PRO A 231
 MG  A 500 ( 4.5A)
PYR  A 435 ( 3.2A)
PYR  A 435 (-3.5A)
PYR  A 435 (-4.1A)
 1.27A 6fgdA-3oyzA:
undetectable		 6fgdA-3oyzA:
22.95