SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 284
GLY A  11
GLY A  15
LEU A 107
ILE A  38
 None
FAD  A 501 ( 4.7A)
None
None
None
 1.12A 1x1aA-3oz2A:
undetectable		 1x1aA-3oz2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		4 / 4 GLY A 164
SER A 161
VAL A   9
LEU A 278
 None
None
FAD  A 501 ( 4.8A)
None
 1.23A 1yajB-3oz2A:
undetectable		 1yajB-3oz2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A  10
THR A  17
ALA A  18
ALA A  19
 FAD  A 501 (-3.4A)
None
None
None
 0.49A 2ej3A-3oz2A:
undetectable		 2ej3A-3oz2A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 GLY A  10
GLY A  11
GLU A  33
ARG A  35
ALA A 124
 FAD  A 501 (-3.4A)
FAD  A 501 ( 4.7A)
FAD  A 501 (-2.7A)
None
FAD  A 501 (-3.8A)
 1.11A 2vdvE-3oz2A:
undetectable		 2vdvE-3oz2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 9 ILE A 288
GLY A 295
GLY A 282
PHE A 335
HIS A 339
 FAD  A 501 ( 4.8A)
FAD  A 501 (-3.0A)
FAD  A 501 (-3.5A)
None
None
 1.34A 2y7wA-3oz2A:
undetectable		 2y7wA-3oz2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 GLY A 223
GLY A 208
GLY A 225
LEU A 201
LEU A 357
 None
OZ2  A 502 ( 3.9A)
OZ2  A 502 ( 4.0A)
None
None
 1.11A 2zbpA-3oz2A:
undetectable		 2zbpA-3oz2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 198
PHE A 199
LEU A 201
 None
OZ2  A 502 ( 3.8A)
None
 0.73A 2zi9A-3oz2A:
undetectable		 2zi9A-3oz2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 ARG A 165
GLY A 282
GLY A  11
GLY A  10
VAL A   9
 None
FAD  A 501 (-3.5A)
FAD  A 501 ( 4.7A)
FAD  A 501 (-3.4A)
FAD  A 501 ( 4.8A)
 0.84A 3cyxB-3oz2A:
undetectable		 3cyxB-3oz2A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		6 / 12 VAL A   9
GLY A  10
GLY A  11
GLU A  33
LYS A  34
ALA A 124
 FAD  A 501 ( 4.8A)
FAD  A 501 (-3.4A)
FAD  A 501 ( 4.7A)
FAD  A 501 (-2.7A)
None
FAD  A 501 (-3.8A)
 1.01A 3fuuA-3oz2A:
2.8		 3fuuA-3oz2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		6 / 12 VAL A   9
GLY A  10
GLY A  12
GLU A  33
LYS A  34
ALA A 124
 FAD  A 501 ( 4.8A)
FAD  A 501 (-3.4A)
FAD  A 501 (-3.4A)
FAD  A 501 (-2.7A)
None
FAD  A 501 (-3.8A)
 1.01A 3fuuA-3oz2A:
2.8		 3fuuA-3oz2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A  83
ALA A  72
ILE A 291
ARG A 341
LEU A 378
 None
GOL  A 515 ( 4.4A)
OZ2  A 502 (-4.8A)
None
None
 1.26A 3ia4B-3oz2A:
undetectable		 3ia4B-3oz2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 10 LEU A  30
ASP A 157
VAL A 153
GLY A 126
LEU A   7
 None
 1.00A 3ogqA-3oz2A:
undetectable		 3ogqA-3oz2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		4 / 6 GLU A 144
ILE A 145
GLU A 162
VAL A   9
 None
None
FAD  A 501 (-3.9A)
FAD  A 501 ( 4.8A)
 1.11A 4ejwB-3oz2A:
undetectable		 4ejwB-3oz2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 11 ILE A  83
ALA A  72
ILE A 291
ARG A 341
LEU A 378
 None
GOL  A 515 ( 4.4A)
OZ2  A 502 (-4.8A)
None
None
 1.29A 4qi9C-3oz2A:
undetectable		 4qi9C-3oz2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 137
THR A 310
GLY A 277
THR A 274
TYR A 319
 None
None
None
GOL  A 514 (-3.8A)
None
 1.14A 5hfjB-3oz2A:
undetectable		 5hfjB-3oz2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 137
THR A 310
GLY A 277
THR A 274
TYR A 319
 None
None
None
GOL  A 514 (-3.8A)
None
 1.10A 5hfjC-3oz2A:
undetectable		 5hfjC-3oz2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 137
THR A 310
GLY A 277
THR A 274
TYR A 319
 None
None
None
GOL  A 514 (-3.8A)
None
 1.05A 5hfjG-3oz2A:
undetectable		 5hfjG-3oz2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		4 / 5 HIS A 339
ASP A 283
GLY A 282
ASN A 298
 None
FAD  A 501 (-2.7A)
FAD  A 501 (-3.5A)
EDO  A 509 ( 3.4A)
 1.34A 5x7pB-3oz2A:
undetectable		 5x7pB-3oz2A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE
(Thermoplasma
acidophilum) 		5 / 9 VAL A 134
GLY A 277
ILE A  32
ARG A 149
ASP A 147
 None
 1.35A 6c2mC-3oz2A:
undetectable		 6c2mC-3oz2A:
9.60