SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 9 LEU A 225
GLY A 218
ILE A 140
ILE A 119
ILE A 224
None
1.00A 1hpvA-3oz6A:
undetectable
1hpvA-3oz6A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 7 LYS A  40
VAL A  72
MET A  93
LEU A 141
None
0.83A 1iepB-3oz6A:
21.0
1iepB-3oz6A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 7 LEU A 118
VAL A 114
ILE A 101
VAL A 100
None
0.77A 1p2yA-3oz6A:
undetectable
1p2yA-3oz6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 6 TYR A 116
TYR A 113
GLU A 341
PRO A 338
None
1.37A 1q13A-3oz6A:
undetectable
1q13A-3oz6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 ALA A  38
GLU A  58
LEU A  62
LEU A 125
HIS A 132
None
0.68A 1uwhA-3oz6A:
20.7
1uwhA-3oz6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
3 / 3 HIS A 110
ASP A 300
ASN A 296
None
0.86A 1wg8B-3oz6A:
undetectable
1wg8B-3oz6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 ILE A 230
GLY A 222
LEU A 309
VAL A 114
ILE A 140
None
1.10A 1zq9A-3oz6A:
undetectable
1zq9A-3oz6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 ALA A  38
LYS A  40
GLU A  58
VAL A  72
MET A  93
LEU A 141
ALA A 151
None
0.77A 2zvaA-3oz6A:
22.6
2zvaA-3oz6A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 6 ASN A  82
ALA A  80
HIS A   6
ASP A   4
None
1.25A 3aruA-3oz6A:
undetectable
3aruA-3oz6A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 5 LEU A 217
GLN A 117
HIS A 126
LEU A 125
None
1.16A 3ce6D-3oz6A:
undetectable
3ce6D-3oz6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 9 VAL A  25
LYS A  40
VAL A  72
LEU A 141
VAL A 150
None
0.75A 3cs9B-3oz6A:
21.2
3cs9B-3oz6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 9 VAL A  25
LYS A  40
VAL A  72
MET A  93
VAL A 150
None
0.80A 3cs9C-3oz6A:
20.9
3cs9C-3oz6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 6 VAL A  25
LYS A  40
VAL A  72
MET A  93
None
0.81A 3mssD-3oz6A:
21.0
3mssD-3oz6A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 LEU A 225
GLY A 218
ILE A 140
ILE A 119
ILE A 224
None
0.96A 3nduD-3oz6A:
undetectable
3nduD-3oz6A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 VAL A  25
ALA A  38
LYS A  40
GLU A  58
TYR A  92
LEU A 141
ALA A 151
None
0.87A 3oezB-3oz6A:
20.3
3oezB-3oz6A:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A2000_1
(P38A)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 ILE A 295
TRP A 288
ILE A 284
ILE A 230
ALA A 299
None
1.20A 3ohtA-3oz6A:
4.8
3ohtB-3oz6A:
8.3
3ohtA-3oz6A:
33.18
3ohtB-3oz6A:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B2000_1
(P38A)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 10 ARG A 197
ILE A 201
ILE A 122
ILE A 119
MET A 214
None
1.48A 3ohtA-3oz6A:
7.1
3ohtB-3oz6A:
9.2
3ohtA-3oz6A:
33.18
3ohtB-3oz6A:
33.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 9 LYS A  40
MET A  93
ARG A  57
LEU A 141
VAL A 150
None
1.47A 3oxzA-3oz6A:
20.8
3oxzA-3oz6A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
8 / 12 VAL A  25
ALA A  38
LYS A  40
GLU A  58
VAL A  72
TYR A  92
LEU A 141
ALA A 151
None
0.75A 3qlgA-3oz6A:
21.0
3qlgA-3oz6A:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 ALA A  38
GLU A  58
LEU A  62
TYR A  92
LEU A 125
HIS A 132
ALA A 151
None
0.90A 3rgfA-3oz6A:
13.0
3rgfA-3oz6A:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
8 / 12 VAL A  25
ALA A  38
GLU A  58
LEU A  62
PHE A  90
TYR A  92
HIS A 132
ALA A 151
None
1.08A 3rgfA-3oz6A:
13.0
3rgfA-3oz6A:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 9 ALA A  38
VAL A  72
PHE A  90
ASP A  96
LEU A 141
None
0.76A 3ti1A-3oz6A:
25.9
3ti1A-3oz6A:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 5 LYS A  40
VAL A  72
LEU A 141
ASP A 152
None
0.85A 3wzdA-3oz6A:
21.3
3wzdA-3oz6A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 5 HIS A 126
LEU A 313
LEU A 221
ASP A 310
None
1.05A 4aqlA-3oz6A:
undetectable
4aqlA-3oz6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 5 LEU A  65
TYR A  92
MET A  93
ARG A 133
None
1.38A 4bkjB-3oz6A:
19.8
4bkjB-3oz6A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 5 VAL A  25
ILE A  71
TYR A  92
MET A  93
None
0.64A 4c8bA-3oz6A:
20.4
4c8bA-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 ALA A  38
GLU A  58
LEU A  62
ILE A  71
HIS A 132
LEU A 141
ALA A 151
None
0.81A 4c8bB-3oz6A:
20.6
4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 ALA A  38
LYS A  40
LEU A  62
ILE A  71
HIS A 132
LEU A 141
ALA A 151
None
0.87A 4c8bB-3oz6A:
20.6
4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
3 / 3 TYR A  92
MET A  93
ILE A  71
None
0.78A 4c8bB-3oz6A:
20.6
4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
3 / 3 TYR A  92
MET A  93
ILE A 140
None
0.87A 4c8bB-3oz6A:
20.6
4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 ALA A  38
GLU A  58
ILE A  61
VAL A  72
TYR A  92
LEU A 141
ALA A 151
None
1.04A 4csvA-3oz6A:
21.1
4csvA-3oz6A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 VAL A  25
ALA A  38
GLU A  58
VAL A  72
TYR A  92
LEU A 141
ALA A 151
None
0.89A 4csvA-3oz6A:
21.1
4csvA-3oz6A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 11 VAL A  25
ALA A  38
LYS A  40
ASP A  96
LEU A 141
None
0.63A 4iaaA-3oz6A:
22.6
4iaaA-3oz6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
3 / 3 LYS A 136
PRO A 137
SER A 138
None
0.33A 4k50I-3oz6A:
0.3
4k50I-3oz6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
4 / 7 ALA A  38
MET A  93
ASP A  96
LEU A 141
None
0.82A 4l9iA-3oz6A:
8.4
4l9iA-3oz6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
3 / 3 ARG A 373
GLU A  64
ARG A 374
None
0.90A 4mwvA-3oz6A:
undetectable
4mwvA-3oz6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 VAL A  25
ALA A  38
LYS A  40
VAL A  72
TYR A  92
MET A  93
LEU A 141
None
0.78A 4mxxB-3oz6A:
20.5
4mxxB-3oz6A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
6 / 12 ALA A  38
LYS A  40
GLU A  58
TYR A  92
LEU A 141
ALA A 151
None
0.67A 4qmnA-3oz6A:
24.3
4qmnA-3oz6A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
6 / 12 ALA A  38
LYS A  40
GLU A  58
TYR A  92
LEU A 141
ASP A 152
None
0.81A 4qmnA-3oz6A:
24.3
4qmnA-3oz6A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 ALA A  38
GLU A  58
HIS A 132
LEU A 141
ALA A 151
None
0.70A 4tyjA-3oz6A:
20.7
4tyjA-3oz6A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
8 / 12 ALA A  38
LYS A  40
GLU A  58
VAL A  72
TYR A  92
MET A  93
LEU A 141
ALA A 151
None
0.75A 4xliA-3oz6A:
23.0
4xliA-3oz6A:
24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
6 / 12 ALA A  38
VAL A  72
PHE A  90
ASP A  96
LEU A 141
ALA A 151
None
0.73A 5l2iA-3oz6A:
13.9
5l2iA-3oz6A:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
7 / 12 VAL A  25
ALA A  38
VAL A  72
PHE A  90
ASP A  96
LEU A 141
ALA A 151
None
0.91A 5l2tA-3oz6A:
14.3
5l2tA-3oz6A:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 ALA A  38
VAL A  72
HIS A 132
LEU A 141
ALA A 151
None
0.78A 5mo4A-3oz6A:
18.6
5mo4A-3oz6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 GLY A 204
ILE A 169
PHE A 262
THR A 166
VAL A 165
None
1.39A 5nz0A-3oz6A:
undetectable
5nz0A-3oz6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
3 / 3 LYS A  40
LEU A 141
ASP A 152
None
0.71A 5zv2A-3oz6A:
21.6
5zv2A-3oz6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
3 / 3 TYR A  92
LEU A 141
ASP A 152
None
0.39A 5zv2B-3oz6A:
21.2
5zv2B-3oz6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 GLY A 222
ASP A 300
VAL A 115
LEU A 118
ILE A 119
None
0.97A 6ectA-3oz6A:
undetectable
6ectA-3oz6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum)
5 / 12 GLY A 222
ASP A 300
VAL A 115
LEU A 118
ILE A 119
None
1.00A 6ecxA-3oz6A:
undetectable
6ecxA-3oz6A:
20.51