SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ozx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 8 LEU A 406
ALA A 478
LEU A 480
THR A 342
 None
 0.94A 1dvtA-3ozxA:
undetectable
1dvtB-3ozxA:
undetectable		 1dvtA-3ozxA:
12.69
1dvtB-3ozxA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 8 ASP A 484
THR A 382
HIS A 518
ILE A 379
 MG  A 613 ( 3.9A)
MG  A 613 ( 3.0A)
None
ADP  A 615 (-4.5A)
 0.92A 1ei6C-3ozxA:
2.2		 1ei6C-3ozxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 520
ASP A 524
LEU A 549
ARG A 566
 None
 1.09A 1mt1A-3ozxA:
undetectable
1mt1F-3ozxA:
undetectable		 1mt1A-3ozxA:
7.82
1mt1F-3ozxA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		5 / 12 GLY A 215
GLY A 216
LEU A 243
LEU A 222
MET A 202
 None
 1.03A 1mx1F-3ozxA:
undetectable		 1mx1F-3ozxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 5 ARG A 566
LEU A 520
ASP A 524
LEU A 549
 None
 1.01A 1n13B-3ozxA:
undetectable
1n13C-3ozxA:
undetectable		 1n13B-3ozxA:
12.28
1n13C-3ozxA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 7 LEU A 520
ASP A 524
LEU A 549
ARG A 566
 None
 1.04A 1n13I-3ozxA:
undetectable
1n13L-3ozxA:
undetectable		 1n13I-3ozxA:
7.82
1n13L-3ozxA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 4 LYS A 192
LEU A 258
LEU A 227
SER A 226
 None
 1.30A 1tt6A-3ozxA:
undetectable		 1tt6A-3ozxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 4 LYS A 192
LEU A 258
LEU A 227
SER A 226
 None
 1.48A 1tz8D-3ozxA:
undetectable		 1tz8D-3ozxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 1.04A 1v54A-3ozxA:
undetectable
1v54J-3ozxA:
undetectable		 1v54A-3ozxA:
18.83
1v54J-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 4 GLY A 217
SER A 214
VAL A 169
LEU A 243
 None
 1.25A 1yajB-3ozxA:
undetectable		 1yajB-3ozxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 1.06A 2dyrA-3ozxA:
undetectable
2dyrJ-3ozxA:
undetectable		 2dyrA-3ozxA:
18.83
2dyrJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 1.05A 2dysN-3ozxA:
undetectable
2dysW-3ozxA:
undetectable		 2dysN-3ozxA:
18.83
2dysW-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 1.08A 2eijA-3ozxA:
undetectable
2eijJ-3ozxA:
undetectable		 2eijA-3ozxA:
18.83
2eijJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 1.03A 2eilA-3ozxA:
undetectable
2eilJ-3ozxA:
undetectable		 2eilA-3ozxA:
18.83
2eilJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 8 SER A 521
LEU A 271
LEU A 308
ARG A 572
 None
 0.92A 2j2pA-3ozxA:
undetectable
2j2pB-3ozxA:
undetectable		 2j2pA-3ozxA:
19.49
2j2pB-3ozxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		3 / 3 THR A 278
ASP A 567
SER A 598
 None
 0.82A 2nxeA-3ozxA:
undetectable		 2nxeA-3ozxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		3 / 3 THR A 278
ASP A 567
SER A 598
 None
 0.82A 2nxeB-3ozxA:
3.2		 2nxeB-3ozxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		5 / 12 ILE A 526
ALA A 527
GLY A 372
ILE A 522
VAL A 482
 None
 0.90A 2qe6A-3ozxA:
undetectable		 2qe6A-3ozxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 7 ARG A 566
LEU A 520
ASP A 524
LEU A 549
 None
 1.05A 2qqcB-3ozxA:
undetectable
2qqcC-3ozxA:
undetectable		 2qqcB-3ozxA:
13.55
2qqcC-3ozxA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 7 LEU A 520
ASP A 524
LEU A 549
ARG A 566
 None
 1.04A 2qqcA-3ozxA:
undetectable
2qqcF-3ozxA:
undetectable		 2qqcA-3ozxA:
7.92
2qqcF-3ozxA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 7 LEU A 520
ASP A 524
LEU A 549
ARG A 566
 None
 1.05A 2qqcI-3ozxA:
undetectable
2qqcL-3ozxA:
undetectable		 2qqcI-3ozxA:
7.92
2qqcL-3ozxA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 7 LEU A 520
ASP A 524
LEU A 549
ARG A 566
 None
 1.00A 2qqdA-3ozxA:
undetectable
2qqdE-3ozxA:
undetectable		 2qqdA-3ozxA:
7.53
2qqdE-3ozxA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 1.07A 3asnA-3ozxA:
undetectable
3asnJ-3ozxA:
undetectable		 3asnA-3ozxA:
18.83
3asnJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 1.07A 3asoA-3ozxA:
undetectable
3asoJ-3ozxA:
undetectable		 3asoA-3ozxA:
18.83
3asoJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 5 LEU A 433
GLN A 423
LEU A 425
GLU A 426
 None
 1.06A 3h5gA-3ozxA:
undetectable
3h5gB-3ozxA:
undetectable		 3h5gA-3ozxA:
4.46
3h5gB-3ozxA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		5 / 12 THR A 513
ILE A 497
ARG A 446
LEU A 474
ILE A 470
 None
 1.10A 3ijdA-3ozxA:
undetectable		 3ijdA-3ozxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 8 ARG A 566
ASP A 519
TYR A 496
LEU A 549
 None
 1.26A 3jq7B-3ozxA:
undetectable		 3jq7B-3ozxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		5 / 12 LEU A 520
VAL A 562
TYR A 593
LEU A 374
PRO A 376
 None
 1.17A 3mecA-3ozxA:
undetectable		 3mecA-3ozxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 5 TYR A 417
PRO A 415
LEU A 468
TYR A 469
 None
 1.29A 4w5qA-3ozxA:
undetectable		 4w5qA-3ozxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 6 TYR A 417
PRO A 415
LEU A 468
TYR A 469
 None
 1.35A 4z4cA-3ozxA:
undetectable		 4z4cA-3ozxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		5 / 9 LEU A 388
ALA A 385
ASP A 484
VAL A 360
ILE A 349
 None
None
MG  A 613 ( 3.9A)
None
None
 1.17A 5om2A-3ozxA:
undetectable
5om2B-3ozxA:
undetectable		 5om2A-3ozxA:
9.11
5om2B-3ozxA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 8 ILE A 522
THR A 513
VAL A 512
GLU A 369
 None
 1.05A 6fbvC-3ozxA:
undetectable		 6fbvC-3ozxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 7 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 0.95A 6nmfA-3ozxA:
undetectable
6nmfJ-3ozxA:
undetectable		 6nmfA-3ozxA:
18.83
6nmfJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 7 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 0.93A 6nmpA-3ozxA:
undetectable
6nmpJ-3ozxA:
undetectable		 6nmpA-3ozxA:
18.83
6nmpJ-3ozxA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ozx RNASE L INHIBITOR
(Sulfolobus
solfataricus) 		4 / 5 LEU A 549
ARG A 565
THR A 563
LEU A 557
 None
 0.92A 6nmpN-3ozxA:
undetectable
6nmpW-3ozxA:
undetectable		 6nmpN-3ozxA:
18.83
6nmpW-3ozxA:
6.64